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		<title>New drug could flip the script for stroke treatment, but small Canadian biotech needs funding boost</title>
		<link>https://goodshepherdmedia.net/new-drug-could-flip-the-script-for-stroke-treatment-but-small-canadian-biotech-needs-funding-boost/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Fri, 29 Jul 2022 01:27:56 +0000</pubDate>
				<category><![CDATA[Health]]></category>
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		<category><![CDATA[🧠Stroke⚕️🏥]]></category>
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					<description><![CDATA[New drug could flip the script for stroke treatment, but small Canadian biotech needs funding boost Researchers used a new peptide drug in an animal model of severe ischemic stroke and found that it improved motor function, sensory function, spatial learning and memory. (iStock / Getty Images Plus) What Does It Take to Cure Cancer? [&#8230;]]]></description>
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<h1 class="element-title hero mb-0" style="text-align: center;">New drug could flip the script for stroke treatment, but small Canadian biotech needs funding boost</h1>
<blockquote><p><em>Researchers used a new peptide drug in an animal model of severe ischemic stroke and found that it improved motor function, sensory function, spatial learning and memory. (iStock / Getty Images Plus)</em></p></blockquote>
<h3 id="gam-title">What Does It Take to Cure Cancer? Plant Roots of Scientific Discovery and Grow Them into an Ecosystem of Collaboration and Innovation.</h3>
<p>Once a stroke happens, the damage can&#8217;t be repaired by any drug on the market. But scientists think they have found an option that could protect and repair the damage that occurs with a stroke up to a week after onset—but limited resources may block its path to clinic. Providing the right conditions for science to thrive is crucial to uncovering a cure for cancer. Discover ways to cultivate an environment for growth to ultimately make an impact for patients.</p>
<p>There’s only one drug on the market for stroke treatment: <span style="color: #0000ff;"><strong>Activase</strong></span>, sold by Roche&#8217;s Genentech, has to be <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840541/#:~:text=Intravenous%20administration%20of%20alteplase%20is,patients%20with%20acute%20ischemic%20stroke." target="_blank" rel="noopener">administered</a> within 4.5 hours of stroke onset. Most investigational stroke therapies currently under investigation also must be given within one to two days of the condition’s onset.</p>
<p>Researchers now believe they have identified a peptide that could change the script entirely for stroke treatment.</p>
<p>Scientists at the University of Cincinnati and Case Western Reserve University in Cleveland have found that the drug, dubbed NVG-291-R, supports nervous system repair and significant functional recovery in an animal model of severe ischemic stroke, as published in <a href="https://dx.doi.org/10.1016/j.celrep.2022.111137" target="_blank" rel="noopener">Cell Reports</a>.</p>
<p>NVG-291-R reduced neuronal death and showed neuroreparative effects in animal models. The drug repaired damage by forming new neuronal connections and boosting migration of new neurons to the damaged site.</p>
<p>The researchers used NVG-291-R to block signaling pathways known as chondroitin sulfate proteoglycans, resulting in significant behavioral recovery including improved motor function, sensory function, spatial learning and memory. Researchers also found the drug to be effective even when administered as late as seven days after stroke onset.</p>
<p>NervGen Pharma, a clinical-stage biotech based in Canada, currently holds the rights to NVG-291-R and is planning trials in different neuronal damage diseases. Though the aforementioned research assessed the drug’s effect in neurorepair after stroke, NervGen is first launching clinical trials in patients with spinal cord injury, Alzheimer’s disease and multiple sclerosis, starting in 2022 and 2023.</p>
<p>When asked about the absence of stroke patients in its upcoming trial plans, the biotech cited limited resources. NervGen’s initial focus is based on the weight of scientific evidence to support those indications, the potential for positive impact on patients, feasibility of development, investor sentiment and commercial potential.</p>
<p>“Given this compelling new preclinical data in stroke, we believe there is a solid opportunity to secure non-dilutive funding to advance the program in the clinic through a partnership, either with industry or government,” NervGen said.</p>
<p>By <a href="https://www.fiercebiotech.com/person/gabrielle-masson-0" rel="bookmark"><span class="font-weight-bold">Gabrielle Masson</span></a></p>
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<div><a href="https://www.fiercebiotech.com/research/flipping-script-stroke-treatment-new-drug-may-repair-neurodamage-week-later" target="_blank" rel="noopener">source</a></div>
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<div>Med info from their site</div>
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<h3><b>Indications</b></h3>
<p>Activase<sup>®</sup> (alteplase) is indicated for the treatment of acute ischemic stroke. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Initiate treatment as soon as possible but within 3 hours after symptom onset.</p>
<p>Activase is indicated for use in acute myocardial infarction (AMI) for the reduction of mortality and reduction of the incidence of heart failure.</p>
<p><u>Limitation of Use:</u> The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose AMI puts them at low risk for death or heart failure.</p>
<p>Activase is indicated for the lysis of acute massive pulmonary embolism (PE), defined as:</p>
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<li>Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments.</li>
<li>Acute pulmonary emboli accompanied by unstable hemodynamics, e.g., failure to maintain blood pressure without supportive measures.</li>
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<h3><b>Important Safety Information</b></h3>
<h4><b>Contraindications</b></h4>
<p>Do not administer Activase to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit: current intracranial hemorrhage (ICH); subarachnoid hemorrhage; active internal bleeding; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding (e.g., some neoplasms, arteriovenous malformations, or aneurysms); bleeding diathesis; and current severe uncontrolled hypertension.</p>
<p>Do not administer Activase to treat acute myocardial infarction or pulmonary embolism in the following situations in which the risk of bleeding is greater than the potential benefit: active internal bleeding; history of recent stroke; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding; bleeding diathesis; and current severe uncontrolled hypertension.</p>
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<h4><b>Warnings and Precautions</b></h4>
<h5><i><b>Bleeding</b></i></h5>
<p>Activase can cause significant, sometimes fatal internal or external bleeding, especially at arterial and venous puncture sites. Avoid intramuscular injections and trauma to the patient. Perform venipunctures carefully and only as required. Fatal cases of hemorrhage associated with traumatic intubation in patients administered Activase have been reported. Aspirin and heparin have been administered concomitantly with and following infusion with Activase in the management of acute myocardial infarction and pulmonary embolism. The concomitant administration of heparin and aspirin with and following infusions of Activase for the treatment of acute ischemic stroke during the first 24 hours after symptom onset has not been investigated. Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. Hemorrhage can occur 1 or more days after administration of Activase, while patients are still receiving anticoagulant therapy. If serious bleeding occurs, terminate the Activase infusion, and treat appropriately.</p>
<p>In the following conditions, the risks of bleeding with Activase are increased and should be weighed against the anticipated benefits: recent major surgery or procedure; cerebrovascular disease; recent intracranial hemorrhage; recent gastrointestinal or genitourinary bleeding; recent trauma; hypertension; acute pericarditis; subacute bacterial endocarditis; hemostatic defects including those secondary to severe hepatic or renal disease; significant hepatic dysfunction; pregnancy; diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions; septic thrombophlebitis or occluded AV cannula at seriously infected site; advanced age; and patients currently receiving oral anticoagulants, or any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location.</p>
<h5><i><b>Hypersensitivity</b></i></h5>
<p>Hypersensitivity, including urticarial / anaphylactic reactions, have been reported after administration of Activase. Rare fatal outcome for hypersensitivity was reported. Angioedema has been observed during and up to 2 hours after Activase infusion in patients treated for acute ischemic stroke and acute myocardial infarction. In many cases, patients received concomitant angiotensin-converting enzyme inhibitors. Monitor patients treated with Activase during and for several hours after infusion for hypersensitivity. If signs of hypersensitivity occur, e.g. anaphylactoid reaction or angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy (e.g., antihistamines, intravenous corticosteroids, epinephrine).</p>
<h5><i><b>Thromboembolism</b></i></h5>
<p>The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation. Activase has not been shown to treat adequately underlying deep vein thrombosis in patients with PE. Consider the possible risk of re-embolization due to the lysis of underlying deep venous thrombi in this setting.</p>
<h5><i><b>Cholesterol Embolization</b></i></h5>
<p>Cholesterol embolism, sometimes fatal, has been reported rarely in patients treated with thrombolytic agents; the true incidence is unknown. It is associated with invasive vascular procedures (e.g., cardiac catheterization, angiography, vascular surgery) and/or anticoagulant therapy.</p>
<h5><i><b>Coagulation Tests May be Unreliable during Activase Therapy</b></i></h5>
<p>Coagulation tests and/or measures of fibrinolytic activity may be unreliable during Activase therapy unless specific precautions are taken to prevent in vitro artifacts. When present in blood at pharmacologic concentrations, Activase remains active under <i>in vitro</i> conditions, which can result in degradation of fibrinogen in blood samples removed for analysis.</p>
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<h4><b>Adverse Reactions</b></h4>
<p>The most frequent adverse reaction associated with Activase therapy is bleeding.</p>
<p><b>Please see <a href="https://www.gene.com/download/pdf/activase_prescribing.pdf" target="_blank" rel="noopener" data-analytics="{\&quot;component\&quot;:\&quot;safetysnippet\&quot;,\&quot;destinationTitle\&quot;:\&quot;full Prescribing Information\&quot;,\&quot;location\&quot;:\&quot;safetybar\&quot;,\&quot;destinationURL\&quot;:\&quot;https://www.gene.com/download/pdf/activase_prescribing.pdf\&quot;,\&quot;type\&quot;:\&quot;external\&quot;}" data-adobe-analytics-id="lnk-72eacc6c4e" data-adobe-analytics-cmp="{&quot;lnk-72eacc6c4e&quot;:{&quot;destinationTitle&quot;:&quot;full Prescribing Information&quot;,&quot;name&quot;:&quot;link&quot;,&quot;location&quot;:&quot;safetybar&quot;,&quot;destinationURL&quot;:&quot;https://www.gene.com/download/pdf/activase_prescribing.pdf&quot;,&quot;type&quot;:&quot;external&quot;,&quot;key&quot;:&quot;lnk&quot;}}">full Prescribing Information</a> for additional Important Safety Information.</b></p>
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<h3><span style="color: #ff00ff;">find out more directly from the company medication site</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://www.activase.com/" target="_blank" rel="noopener">www.activase.com</a></span></h3>
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		<title>Top 7 Vitamins for Stroke Recovery Based on the Latest Clinical Evidence</title>
		<link>https://goodshepherdmedia.net/top-7-vitamins-for-stroke-recovery-based-on-the-latest-clinical-evidence/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Thu, 06 Jan 2022 11:05:27 +0000</pubDate>
				<category><![CDATA[Health]]></category>
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		<category><![CDATA[Vitamins for Stroke Recovery]]></category>
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					<description><![CDATA[Top 7 Vitamins for Stroke Recovery Based on the Latest Clinical Evidence Vitamins for stroke recovery can help boost brain health, but beware that no single pill fits all. Supplements that enhance one person’s recovery from stroke may worsen recovery in someone else. To avoid this mistake, learn why some stroke supplements can be dangerous [&#8230;]]]></description>
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<h1 class="elementor-heading-title elementor-size-default" style="text-align: center;">Top 7 Vitamins for Stroke Recovery Based on the Latest Clinical Evidence</h1>
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<p>Vitamins for stroke recovery can help boost brain health, but beware that no single pill fits all.</p>
<p>Supplements that enhance one person’s recovery from stroke may worsen recovery in someone else. To avoid this mistake, learn why some stroke supplements can be dangerous for you.</p>
<p>Then, we’ll share an updated list of the best vitamins to enhance stroke recovery.</p>
<h2>Take Supplements for Stroke Recovery with Extreme Caution</h2>
<p>Before we dig into the list of science-backed vitamins and supplements for stroke recovery, you need to proceed with caution.</p>
<p>It is imperative that you consult with your physician before adding supplements to your regimen. Some supplements can interfere with certain medications to worsen your health status and cause complications.</p>
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<p>For example, <strong>ginko biloba</strong> is an herb that is used to help prevent ischemic stroke (the type of stroke caused by a clot) because it’s a natural blood thinner…</p>
<p>However, it can also put people with a history of hemorrhagic stroke (the type of stroke caused by a bleed) at an increased risk of suffering a second stroke. Additionally, complications can arise if you’re already taking blood thinning medication.</p>
<p>Other supplements that contain natural blood thinning properties include: turmeric, ginger, cayenne pepper, vitamin E, garlic, cassia cinnamon, grape seed extract, omega 3s, and bromelain.</p>
<p>Now, let’s dig into the list of the top supplements and vitamins for stroke recovery.</p>
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<p><strong>Want 20 pages of stroke recovery tips in an illustrated PDF? </strong>Download our free ebook by clicking here (link opens a pop up for uninterrupted reading)</p>
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<h2>The Best Science-Backed Vitamins for Stroke Recovery</h2>
<p>Based upon relevant clinical research, here are the best supplements and vitamins for stroke recovery:</p>
<h3>1. Vitamin D</h3>
<p>Research studies show that vitamin D is one of the best vitamins for stroke recovery.</p>
<p>Low levels of vitamin D are associated with worse outcomes after ischemic stroke, which account for 87% of all strokes in America. Furthermore, vitamin D deficiency is associated with the stroke risk factors like hypertension, obesity, and diabetes. (Source: Current Opinion in Clinical Nutrition and Metabolic Care)</p>
<p>Fortunately, after supplementing with vitamin D, “there is a significant improvement in stroke outcomes after 3 months.” (Source: Journal of Clinical and Diagnostic Research)</p>
<p>Getting enough vitamin D can also provide neuroprotective, neuromuscular, and osteoprotective benefits which can reduce cognitive and functional impairments in individuals after a stroke. (Source: Current Drug Targets)</p>
<p>By getting your daily dose of vitamin D, you can reduce your risk of another stroke while aiding your brain’s recovery.</p>
<p><strong>How to get vitamin D naturally:</strong></p>
<p>Your body can produce Vitamin D, known as the sunshine vitamin, from daily amounts of sun exposure. As always, be cautious about your exposure during peak hours (generally 10am-4pm) when the sun’s rays are the strongest.</p>
<p>If you can’t get sun exposure due to medical restrictions (like heightened risk of skin cancer), then consume it through foods that are high in Vitamin D, like fatty fish, cheese, and egg yolks.</p>
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<p>Vitamin D deficiency is associated with poor outcomes after stroke, whereas daily supplementation is associated with better outcomes.</p>
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<h3>2. Probiotics</h3>
<p>Probiotics aren’t a vitamin or mineral. Rather, probiotics are the “good” bacteria that comprise your microbiome, the 100 trillion microbes that live inside your gut.</p>
<p>The bacteria living inside your body serve an important role – they even have a nervous system of their own called the <em>enteric nervous system</em>.</p>
<p>Through this internal ecosystem, the bacteria in your gut communicate with your brain through the <em>gut-brain axis</em>. This connection is <strong>bidirectional</strong>, which means that it goes both ways. (Source: Annals of Gastroenerology)</p>
<p>Since gut health plays a key role in brain health, probiotics make the list of top supplements for stroke recovery.</p>
<p><strong>How to get probiotics naturally:</strong></p>
<p>Great dietary sources of probiotics include fermented foods like yogurt, kefir, tempeh, kimchi, and miso.</p>
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<p>You need “good” bacteria to support your microbiome, which influences brain health and function via the gut-brain axis.</p>
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<h3>3. Vitamin B12</h3>
<p>Vitamin B12 deficiency is associated with a type of inflammation that damages the blood vessels. When blood vessels become damaged, excess deposits can develop and interrupt blood flow. If this happens to an artery in the brain, it can lead to a stroke. (Source: VeryWell Health)</p>
<p>Supplementing with vitamin B12 can enhance stroke recovery by boosting the function and development of the brain and nerve cells. (Source: Viatcheslav Wlassoff, PhD)</p>
<p>This encourages neuroplasticity, which is the brain’s ability to reorganize itself, create new neural pathways, and rearrange existing ones.</p>
<p><strong>How to get vitamin B12 naturally:</strong></p>
<p>Vitamin B12 can be found in animal products like fish, meat, poultry, eggs, and milk. If you have a history of stroke risk factors like high cholesterol or atherosclerosis, consume lean sources of protein such as fish or poultry.</p>
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<p>Vitamin B12 provides essential support for both brain and blood vessel health.</p>
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<h3>4. Vitamin B3 (Niacin)</h3>
<p>Vitamin B3, also known as niacin, can encourage recovery of brain function after stroke for two main reasons:</p>
<p>First, niacin directly affects neuroplasticity, which is the primary driver of recovery from stroke. Secondly, niacin has been proven to improve “good” cholesterol levels, which are statistically low in stroke survivors. (Source: MedicineNet)</p>
<p>Although experts have yet to link “good” cholesterol levels with stroke recovery, reducing one’s risk of a second stroke is a significant accomplishment.</p>
<p><strong>How to get niacin naturally:</strong></p>
<p>You can find vitamin B3 in tuna, chicken, turkey, and salmon. For meatless options, you can find lesser quantities of niacin in peanuts and brown rice.</p>
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<p>Vitamin B3 positively affects neuroplasticity, which is driving mechanism of stroke recovery.</p>
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<h3>5. DHA (Docosahexaenoic acid)</h3>
<p>DHA is an omega-3 fatty acid that is critical for healthy brains. While omega-3s are not vitamins, they still made the list for their positive effects on stroke recovery.</p>
<p>DHA is essential for brain growth in infants and maintenance of normal brain function in adults. Some studies suggest that DHA can reduce stroke risk factors like hypertension and atherosclerosis. (Source: Pharmacological Research)</p>
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<p>Be aware that fish oil is contraindicated for some blood thinners, such as Warfarin. Check with your physician to see if this supplement is safe for you. (Source: Annals of Pharmacotherapy)</p>
<p><strong>How to get DHA:</strong></p>
<p>DHA is an essential fatty acid, meaning your body cannot produce it on its own – you must get it from your diet (or supplements).</p>
<p>Fatty fish, like salmon, contain healthy amounts of DHA. If you are on a strict heart healthy diet, then consider taking fish oil supplements to obtain your daily amount of DHA.</p>
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<p>DHA can improve healthy brain function and must be consumed through diet or supplements.</p>
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<h3>6. Coenzyme Q10 (CoQ10)</h3>
<p>CoQ10 is most famous for improving heart health – but it holds incredible benefits for your brain, too. This is why CoQ10 made the list of top vitamins for stroke recovery, even though it’s a nutrient and not a vitamin.</p>
<p>CoQ10 is a powerful antioxidant that provides protection from free radicals, which are toxic molecules associated with disease. Free radicals are believed to play a role in cardiovascular disease, which is a precursor to stroke.</p>
<p>By supplementing with CoQ10, you can improve your heart health and, therefore, reduce your risk of a second stroke.</p>
<p>Also, low CoQ10 levels have been associated with greater tissue damage to the brain during stroke.</p>
<p><strong>How to get CoQ10 naturally:</strong></p>
<p>CoQ10 can be found in most liver organ meats like heart, liver, and kidney. However, these meats also contain high amounts of cholesterol and saturated fats that exacerbate cardiovascular disease.</p>
<p>Small amounts of CoQ10 can be found in spinach, broccoli, and cauliflower. Due to this, supplementation may be more suitable for individuals recovering from a stroke.</p>
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<p>CoQ10 can boost recovery from stroke by protecting you from damaging free radicals associated with cardiovascular disease.</p>
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<h3>7. Vitamin C</h3>
<p>Vitamin C deficiency may be a stroke risk factor, especially in individuals with a history of hemorrhagic strokes (the type of stroke caused by a burst artery in the brain).</p>
<p>In a study from the American Academy of Neurology, 65 survivors of hemorrhagic stroke were compared to 65 healthy people. On average, those who suffered a stroke had depleted levels of vitamin C while healthy people did not.</p>
<p>Study author Stephane Vannier, MD, concluded that “vitamin C deficiency should be considered a risk factor for this severe type of stroke.”</p>
<p><strong>How to get vitamin C naturally:</strong></p>
<p>Although oranges are well-known for their nutritional benefits, other fruits and vegetables, like papaya, bell peppers, broccoli, and strawberries, contain higher amounts of vitamin C.</p>
<p>Dr. Stephane Vannier, from Pontchaillou University Hospital in Rennes, does not recommend supplementing vitamin C if you are not deficient.</p>
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<p>People with a history of hemorrhagic stroke should pay attention to their vitamin C levels to promote overall health and wellness.</p>
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<h2>How to Get These Stroke Supplements without Breaking Your Budget</h2>
<p>Consider obtaining these supplements through your diet as opposed to costly pills and herbal remedies.</p>
<p>Eat a variety of whole foods every day, especially foods that help stroke recovery, in order to avoid developing a nutritional deficiency. Prioritize meals with minimal processing, which can strip foods of essential vitamins and minerals.</p>
<p>If you are unable to consume these vitamins and minerals through your diet, then consult with your physician prior to adding supplement to your medication regimen.</p>
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<p>Medically reviewed by Andrew Tran PT, DPT, NCS, CSCS <a href="https://www.flintrehab.com/vitamins-for-stroke-recovery/" target="_blank" rel="noopener">source</a></p>
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<h3><strong>always consult with your physician!</strong> <img decoding="async" class="size-full wp-image-11261 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/02/warning.jpg" alt="" width="150" height="150" /></h3>
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		<title> tPA a plasminogen activator used in HIV Treatment could improve recovery after stroke</title>
		<link>https://goodshepherdmedia.net/tpa-a-plasminogen-activator-used-in-hiv-treatment-could-improve-recovery-after-stroke/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Fri, 31 Dec 2021 11:10:53 +0000</pubDate>
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					<description><![CDATA[ tPA a plasminogen activator used in HIV Drug Treatment could improve recovery after stroke A protein that may hinder the brain’s regrowth after damage points researchers to an unexpected treatment Stroke treatment has been a race against time. In the hours after a stroke, the clot-busting treatment tissue plasminogen activator (tPA) can limit damage to the [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 class="news-article__hero__title" style="text-align: center;"> tPA a plasminogen activator used in HIV Drug Treatment could improve recovery after stroke</h1>
<h2 class="news-article__hero__subtitle h5 font-weight-normal serif mt-1" style="text-align: center;">A protein that may hinder the brain’s regrowth after damage points researchers to an unexpected treatment</h2>
<p>Stroke treatment has been a race against time. In the hours after a stroke, the clot-busting treatment tissue plasminogen activator (tPA) can limit damage to the brain. But once that damage is done, no drugs are known to promote recovery. New research suggests such a therapy could come from an unlikely target: <a href="https://www.cell.com/cell/fulltext/S0092-8674(19)30107-2">a cellular protein called CCR5 that allows HIV to infect cells</a>. Scientists found that in mice, disabling CCR5 helps surviving neurons make new connections, and that people who carry a CCR5 mutation may recover better from a stroke.</p>
<p>&#8220;This is the first real molecular target to improve recovery after stroke,&#8221; says Argye Hillis, a stroke neurologist at Johns Hopkins University School of Medicine in Baltimore, Maryland, who was not involved in the work. A clinical trial will soon test its promise by giving stroke patients an HIV drug that blocks CCR5.</p>
<p>White blood cells display CCR5 on their surface to intercept signals from molecules called chemokines and coordinate an immune response. But HIV exploits CCR5, grabbing onto it to invade host cells. People with a mutation that cripples the <em>CCR5</em> gene are protected from infection, which is why Chinese scientist He Jiankui recently aimed to mutate <em>CCR5</em> in <a href="http://science.sciencemag.org/content/362/6418/978?adobe_mc=MCMID%3D13053749737729956373080267700945088432%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1675660381">controversial human experiments</a>.</p>
<p>The new discoveries about CCR5 began with a hunt for &#8220;smart mice&#8221;—animals bearing genetic mutations that apparently boost their ability to learn and remember. Neuroscientist Alcino Silva and his team at the University of California, Los Angeles (UCLA), wanted to figure out which of 148 mouse strains had such enhancements. In 2016, they reported that reducing levels of CCR5 in a healthy mouse brain enhanced memory formation and learning.</p>
<p>UCLA stroke neurologist Thomas Carmichael was intrigued. &#8220;When you watch patients recover in stroke, it looks like they&#8217;re relearning to walk or relearning language,&#8221; he says. Indeed, surviving neurons near the injury sprout tendrils to make new contacts across the brain. A drug that targets CCR5 seemed promising for stroke recovery, and that drug was already on hand. Maraviroc, which blocks CCR5, was approved by U.S. regulators in 2007 for use with other antiretroviral drugs to treat HIV infections.</p>
<p>In <em>Cell</em> this week, Silva, Carmichael, and their collaborators showed that CCR5 levels in mouse neurons skyrocket after stroke and can remain elevated for weeks—and that the protein appears to hamper recovery. The team blocked CCR5 with maraviroc or a gene that interferes with its production, and then ran the mice through tests of motor ability—for example, counting how many times their feet slipped as they walked across a metal grid. Treated mice showed greater motor improvements than controls at the end of the 9-week testing period.</p>
<p>Even if the researchers waited until 3 weeks after a stroke to give the animals maraviroc, it improved their performance. In previous studies, nothing has seemed to help at that point, says Dale Corbett, a neuroscientist specializing in stroke recovery at the University of Ottawa. The new results, he says, suggest &#8220;it may be feasible to reopen this recovery window in people.&#8221;</p>
<p>Blocking CCR5 seemed to help maintain connections between neurons adjacent to the injured site. And it caused neurons in motor regions to sprout more projections to the opposite side of the brain, a process that might help a mouse relearn lost movements.</p>
<p>What CCR5 does in the poststroke brain is hazy. Surging CCR5 is part of the inflammatory response to stroke, says Robyn Klein, a neuroimmunologist at Washington University School of Medicine in St. Louis, Missouri. In flammatory molecules may prompt neurons to express more of this chemokine receptor. In the developing brain, chemokines are known to influence how neurons migrate and connect. After stroke, they seem to decrease the number of connection sites on neurons near the damage. (How that process hinders regrowth and recovery isn&#8217;t clear.)</p>
<p>Carmichael notes that blocking CCR5 also caused neurons to express genes that increase their excitability, making them fire more readily. He suspects that neurons boost CCR5 after a stroke to dampen their activity and lie low to avoid a deadly cellular frenzy known as excitotoxicity. But because the protein then sticks around, that protective mechanism gets in the way of recovery.</p>
<p>Mouse results often prove meaningless in people, but when Carmichael&#8217;s group teamed up with researchers behind the Tel Aviv Brain Acute Stroke Cohort (TABASCO) in Israel, they found encouraging clues. Roughly 10% of Europeans have a genetic deletion that cripples CCR5, and the number is higher in Jewish people of Eastern European origin. The TABASCO team identified 68 people in its cohort of stroke survivors who had at least one copy of the CCR5 mutation. Compared with people without the mutation, they performed slightly better on tests of motor and sensory skills and cognitive abilities both 6 months and 1 year after a stroke, the new study found.</p>
<p>&#8220;It wasn&#8217;t gangbusters better, but … the fact that they found anything is impressive,&#8221; says Steven Cramer, a stroke neurologist at UC Irvine, who has studied genes linked to stroke recovery.</p>
<p>Carmichael and his collaborators are now designing a clinical trial that will give 30 people maraviroc starting when they leave an inpatient rehabilitation facility—typically about 4 weeks after a stroke. The team hopes to launch the trial this year.</p>
<p>Meanwhile, some researchers expect the CCR5 story to inspire a broader search for brain repair strategies based on learning and memory genes. &#8220;We&#8217;ve always been talking about having a tPA-like moment for stroke recovery,&#8221; Corbett says. &#8220;Whether this is it or not, I don&#8217;t know, but at least it gives us hope.&#8221;</p>
<p><a href="https://www.science.org/content/article/hiv-drug-could-improve-recovery-after-stroke" target="_blank" rel="noopener">source</a></p>
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		<title>Male Brain versus Female Brain</title>
		<link>https://goodshepherdmedia.net/male-brain-versus-female-brain/</link>
		
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		<pubDate>Mon, 27 Dec 2021 02:23:06 +0000</pubDate>
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					<description><![CDATA[Male Brain 🧠 versus Female Brain 🧠 The minds of men and women are 99% the same, but that 1% may make all the difference. Studies of that 1%, for instance, have found that a female’s frontal lobe, responsible for problem-solving, is larger than in a man. Meanwhile, a male’s amygdala, which regulates the “fight [&#8230;]]]></description>
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<h1 style="text-align: center;" align="justify"><strong>Male Brain <img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f9e0.png" alt="🧠" class="wp-smiley" style="height: 1em; max-height: 1em;" /> versus Female Brain <img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f9e0.png" alt="🧠" class="wp-smiley" style="height: 1em; max-height: 1em;" /></strong></h1>
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<div align="justify"><strong>The minds of men and women are 99% the same, but that 1% may make all the difference. </strong>Studies of that 1%, for instance, have found that a female’s frontal lobe, responsible for problem-solving, is larger than in a man. Meanwhile, a male’s amygdala, which regulates the “fight or flight” reaction, is bigger.</div>
<div align="justify">Many <strong>books</strong> have been written on the subject, including best-sellers by <a href="http://drlouann.ning.com/" target="_blank" rel="noopener">Dr. Louann Brizendine</a> called <a href="http://www.amazon.com/gp/product/0767920104?ie=UTF8&amp;camp=1789&amp;creativeASIN=0767920104&amp;linkCode=xm2&amp;tag=neurorelay-20" target="_blank" rel="noopener"><em>“The Female Brain”</em></a> and <em><a href="http://www.amazon.com/gp/product/0767927540?ie=UTF8&amp;camp=1789&amp;creativeASIN=0767927540&amp;linkCode=xm2&amp;tag=neurorelay-20" target="_blank" rel="noopener">“The Male Brain”</a>, or <a href="http://www.amazon.com/dp/0385528116?tag=neurorelay-20&amp;camp=0&amp;creative=0&amp;linkCode=as1&amp;creativeASIN=0385528116&amp;adid=0AGEF85NF901T42W7J6Y" target="_blank" rel="noopener">“The Male Factor”</a></em> by <a href="http://www.shaunti.com/" target="_blank" rel="noopener">Shaunti Feldhahn</a> and <a href="http://www.amazon.com/gp/product/0979777747/ref=as_li_tf_tl?ie=UTF8&amp;camp=1789&amp;creative=9325&amp;creativeASIN=0979777747&amp;linkCode=as2&amp;tag=neurorelay-20" target="_blank" rel="noopener"><em>“Brain Rules”</em></a> by Dr. <a href="http://www.johnmedina.com/" target="_blank" rel="noopener">John Medina</a>. Brizendine says recognizing differences doesn’t mean that one gender is “better” than the other, but scientists have devoted their research to uncover the secrets of “the gendered brain”. Studies found that men and women use different parts of the brain when doing exercises like using a computer mouse or driving a car. Women often use both sides of the brain, while men use one. Scientists  point out that even though men and women use very different pathways and parts of the brain, they perform equally well on intelligence based tests. You can below more about the science-based differencesbetween the female brain and the male brain.</div>
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<p><strong>FEMALE BRAIN</strong><br />
<a href="http://en.wikipedia.org/wiki/Prefrontal_cortex" target="_blank" rel="noopener"><strong>Prefrontal Cortex</strong></a><br />
Considered the “CEO of the brain,” the PFC makes decisions and inhibits rash behavior. It’s where we process anger, fear, and aggression. It’s larger in women and matures a full two years before men, usually by the early 20s. Because women have larger prefrontal cortexes, they may be less easy to make angry, Brizendine says.<br />
<a href="http://en.wikipedia.org/wiki/Frontal_cortex" target="_blank" rel="noopener"><strong>Frontal Cortex</strong></a><br />
Responsible for much of our decision making ability, it is fatter and more complex in women. Some neuroscientists believe that women are hard-wired to be better decision-makers and problem-solvers.<br />
<a href="http://en.wikipedia.org/wiki/Anterior_cingulate_cortex" target="_blank" rel="noopener"><strong>Anterior Cingulate Cortex</strong></a><br />
The source of women’s “gut feelings” is larger in women. It weighs options, detects conflicts, motivates decisions, and is known as the area of self-consciousness.<br />
<a href="http://en.wikipedia.org/wiki/Insular_cortex" target="_blank" rel="noopener"><strong>Insular Cortex</strong></a><br />
The insula is a portion of the cerebral cortex that processes gut feelings and is larger is women. “The relationship between a woman’s gut feeling and her intuitive hunches is grounded in biology,” Brizendine says.<br />
<a href="http://en.wikipedia.org/wiki/Hippocampus" target="_blank" rel="noopener"><strong>Hippocampus</strong></a><br />
The brain’s memory center that turns short-term memories into long-term ones. It’s larger in women than in men. Women have an often better memory for details, both pleasant and unpleasant, Brizendine says. “It’s the elephant that never forgets a fight, a romantic encounter or a tender moment — and won’t let you either.”<br />
<a href="http://en.wikipedia.org/wiki/Amygdala" target="_blank" rel="noopener"><strong>Amygdala</strong></a><br />
When women were showed a horror film, their left-side amygdala (they have two), which pays attention to detail and internal thought, lit up. When men saw the same slasher flick, their right side was activated, which is associated with action and external environment. Scientists believe this may account for why men are more likely to respond with their fists when attacked or threatened.<br />
<a href="http://en.wikipedia.org/wiki/Mirror_neuron" target="_blank" rel="noopener"><strong>Mirror-Neuron System</strong></a><br />
It’s when neurons in the brain fire when a person experiences an event and when she observes an action. Known as the body’s “empathy” system, which enables a person to “feel” the pain of others. Used in understanding the action of other people, language acquisition through imitation, and the “I know how you feel” sentiment. It’s larger and more active in females, according to a recent study conducted by Dr. Ya-Wei Cheng, a Taiwanese neuroscientist.<br />
<a href="http://en.wikipedia.org/wiki/Limbic_lobe" target="_blank" rel="noopener"><strong>Limbic Cortex</strong></a><br />
Part of the limbic system, responsible for regulating emotion, is larger in women. Scientists say that many women are better able to express emotion because of this. Having larger limbic cortexes, however, make females more likely to suffer from depression, doctors say.<br />
<a href="http://en.wikipedia.org/wiki/White_matter" target="_blank" rel="noopener"><strong>White Matter</strong></a><br />
Women are thought to have 10 times the amount of “white matter” than men. White matter works to network or connect different processing centers of the brain, making a female more efficient in multi-tasking skills. Some researchers believe that it might play a role in why women often excel at language and verbal skills. But, like the gray matter hypothesis, these are controversial conclusion.</div>
<div align="justify"><strong>Bilateral Brain</strong><br />
Neuroscientists have found that women’s brains often have stronger connections between the hemispheres. Research conducted by Indiana University School of Medicine showed that women use both sides of their brain while listening, while men only used one side. This may suggest why women are considered better listeners.</div>
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<p><strong>MALE BRAIN</strong><br />
<a href="http://en.wikipedia.org/wiki/Temporoparietal_junction" target="_blank" rel="noopener"><strong>Temporal Parietal Junction</strong></a><br />
The place where the temporal lobe (responsible for auditory functioning, memory and speech cognition) and the parietal lobe (responsible for sensory information) meet. It is more active in males, MRI’s have shown. TPJ works to cognitively process emotion, which strengthens their ability to cognitively and analytically find a solution to emotional problems as opposed to empathize – which women are more likely to do, says Louann Brizendine (author of <strong>The Female Brain</strong>).<br />
<strong>Size</strong><br />
Men have 9% bigger brains, even after correcting for body size. But men and women share the same amount of neurons, they’re just more densely packed in a woman’s brain.<br />
<a href="http://en.wikipedia.org/wiki/Gray_Matter" target="_blank" rel="noopener"><strong>Gray Matter</strong></a><br />
Men have as much as 6.5 times the amount of “gray matter” as women, according to a study conducted by the University of California, Irvine. Gray matter is associated with information processing, which might explain why some men excel at spatial intelligence and mathematics. Many experts take issue with this leap in logic.<br />
<strong>The infidelity gene?</strong><br />
Several studies, including one at Johns Hopkins, have found that the length of the vasopressin receptor gene, a brain hormone, corresponds to monogamy. The first study was conducted on a prairie vole, which is one of 5% of mammals who are monogamous. A closely related “cousin” called the montane vole is more of a polygamist. Scientists found that the montane vole had a short vasopressin gene while the prairie vole had a longer one. When the scientists injected the trampy montane with a longer gene, he suddenly became a one-woman vole. Scientists have extended the study to human males, finding that the longer the gene (there are 17 known lengths), the more likely a man is to be married or in a monogamous relationship; the shorter, the more likely he is to be a bachelor.<br />
<a href="http://en.wikipedia.org/wiki/Parietal_cortex" target="_blank" rel="noopener"><strong>Parietal Cortex</strong></a><br />
The part of the brain responsible for spatial and somatosensory (sensations in skin and tissue) perceptions is bigger in men, according to recent studies. Some scientists believe this helps to account for better spatial intelligence in men.<br />
<a href="http://en.wikipedia.org/wiki/Hypothalamus" target="_blank" rel="noopener"><strong>Hypothalamus</strong></a><br />
Area in the hypothalamus, which among other things manages memory, controls body temperature, hunger and thirst, has a component for sexual drive that is 2 1/2 times bigger in males than females, Brizendine says. Accordingly, men are constantly bombarded by sexual images that “flicker in the visual cortex all day and night.”<br />
<a href="http://en.wikipedia.org/wiki/Periaqueductal_gray" target="_blank" rel="noopener"><strong>Periaqueductal Gray</strong></a><br />
The PAG, known as the “central gray,” is gray matter located near the midbrain. It helps control pain. During sex, the site suppresses pain and increases pleasure. It’s more active during sex in the male brain.<br />
<a href="http://en.wikipedia.org/wiki/Ventral_tegmental_area" target="_blank" rel="noopener"><strong>Ventral Tegmental Area</strong></a><br />
The VTA is the “motivation center” of the brain, located deep at the mind’s center. It manufactures dopamine, a feel-good neurotransmitter for motivation and reward. The VTA is one of two primary sites where drugs like cocaine, heroin and other narcotics act on the brain. It’s more active in men, which may be a clue to why more alcoholics and drug addicts are male, acording to <strong>Brain Rules</strong> by John Medina.<br />
<a href="http://en.wikipedia.org/wiki/Amygdala" target="_blank" rel="noopener"><strong>Amygdala</strong></a><br />
Known as the “fight or flight” center, the almond-shaped amygdala – there are two, one on the right side, one on the left – is the alarm system for threats, fear and danger. It drives emotional impulses, and triggers protective aggression. It’s larger in men than in women, meaning that men are more likely to have “short fuses” and be driven to physical action, Brizendine says.<br />
<strong>Dorsal Premammillary Nucleus</strong><br />
The DPN that lies deep inside the hypothalamus and contains special circuits to detect territorial defense, fear and aggresion is larger in males. The larger size might make males “more sensitive to potential turf threats”, Brizendine says.</p>
<div id="attachment_3182" class="wp-caption aligncenter" style="width: 929px;">
<p><img loading="lazy" decoding="async" class="alignnone wp-image-9926" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/male_brain.webp" alt="" width="929" height="1119" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/male_brain.webp 517w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/male_brain-249x300.webp 249w" sizes="(max-width: 929px) 100vw, 929px" /></p>
<p><a href="http://neurorelay.com/2012/10/07/female-brain-versus-male-brain/" target="_blank" rel="noopener">source</a></p>
</div>
</div>
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		<title>Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress</title>
		<link>https://goodshepherdmedia.net/combination-of-nad-and-nadph-offers-greater-neuroprotection-in-ischemic-stroke-models-by-relieving-metabolic-stress/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Tue, 07 Dec 2021 11:21:49 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Brain Health🧠]]></category>
		<category><![CDATA[🧠Stroke⚕️🏥]]></category>
		<category><![CDATA[Ischemic Stroke]]></category>
		<category><![CDATA[NAD+]]></category>
		<category><![CDATA[NAD+ and NADPH]]></category>
		<category><![CDATA[NADPH]]></category>
		<category><![CDATA[Neuroprotection]]></category>
		<category><![CDATA[Relieving Metabolic Stress]]></category>
		<category><![CDATA[sTROKE]]></category>
		<category><![CDATA[🧠]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=11267</guid>

					<description><![CDATA[Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress PMID: 29164394 DOI: 10.1007/s12035-017-0809-7 Abstract Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD+) have been reported to have potent neuroprotective effects against ischemic neuronal injury. Both NADPH and NAD+ are essential cofactors for anti-oxidation and cellular energy metabolism. [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 class="heading-title" style="text-align: center;">Combination of NAD<sup>+</sup> and NADPH Offers Greater Neuroprotection<br />
in Ischemic Stroke Models by Relieving Metabolic Stress</h1>
<header id="heading" class="heading">
<div id="full-view-heading" class="full-view">
<ul id="full-view-identifiers" class="identifiers">
<li><span class="identifier pubmed"><span class="id-label">PMID: </span><strong class="current-id" title="PubMed ID">29164394</strong></span></li>
<li><span class="identifier doi"><span class="id-label">DOI: </span><a class="id-link" href="https://doi.org/10.1007/s12035-017-0809-7" target="_blank" rel="noopener" data-ga-category="full_text" data-ga-action="DOI">10.1007/s12035-017-0809-7</a></span></li>
</ul>
</div>
</header>
<div id="abstract" class="abstract">
<h2 class="title">Abstract</h2>
<div id="eng-abstract" class="abstract-content selected">
<p>Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD<sup>+</sup>) have been reported to have potent neuroprotective effects against ischemic neuronal injury. Both NADPH and NAD<sup>+</sup> are essential cofactors for anti-oxidation and cellular energy metabolism. We investigated if combined NADPH and NAD<sup>+</sup> could offer better neuroprotective effects on cellular and animal models of ischemic stroke. In vitro studies with primary cultured neurons demonstrated that NAD<sup>+</sup> was effective in protecting neurons against oxygen-glucose deprivation/reoxygenation (OGD/R) injury when given during the early time period of reoxygenation. In vivo studies in mice also suggested that NAD<sup>+</sup> was effective for ameliorating ischemic brain damage when administered within 2 h after reperfusion. The combination of NADPH and NAD<sup>+</sup> provided not only greater beneficial effects but also larger therapeutic window in both cellular and animal models of stroke. The combination of NADPH and NAD<sup>+</sup> significantly increased the levels of adenosine triphosphate (ATP) and reduced the levels of reactive oxygen species (ROS) and oxidative damage of macromolecules. Furthermore, the combined medication significantly reduced long-term mortality, improved the functional recovery, and inhibited signaling pathways involved in apoptosis and necroptosis after ischemic stroke. The present study indicates that the combination of NAD<sup>+</sup> and NADPH can produce greater therapeutic effects with smaller dose of NADPH; on the other hand, NADPH can significantly prolong the therapeutic window of NAD<sup>+</sup>. The current results suggest that the combination of NADPH and NAD<sup>+</sup> may provide a novel effective therapy for ischemic stroke.</p>
</div>
<p><strong class="sub-title">Keywords: </strong>Apoptosis; NAD+; NADPH; ROS; Stroke.</p>
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<li class="skip-numbering" value="1">Cell Metab. 2015 Jul 7;22(1):31-53 &#8211; <a class="reference-link" href="https://pubmed.ncbi.nlm.nih.gov/26118927/" data-ga-category="reference" data-ga-action="26118927">PubMed</a></li>
</ol>
<ol class="references-and-notes-list">
<li class="skip-numbering" value="1">J Biol Chem. 2004 Apr 30;279(18):18895-902 &#8211; <a class="reference-link" href="https://pubmed.ncbi.nlm.nih.gov/14960594/" data-ga-category="reference" data-ga-action="14960594">PubMed</a></li>
</ol>
<ol class="references-and-notes-list">
<li class="skip-numbering" value="1">Stroke. 2007 Aug;38(8):2329-36 &#8211; <a class="reference-link" href="https://pubmed.ncbi.nlm.nih.gov/17600230/" data-ga-category="reference" data-ga-action="17600230">PubMed</a></li>
</ol>
</li>
</ol>
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		<title>How are a stroke and heart attack different?</title>
		<link>https://goodshepherdmedia.net/how-are-a-stroke-and-heart-attack-different/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Mon, 06 Dec 2021 10:34:00 +0000</pubDate>
				<category><![CDATA[❤️Heart Attack❤️]]></category>
		<category><![CDATA[❤️Heart Health⚕️]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Brain Health🧠]]></category>
		<category><![CDATA[🧠Stroke⚕️🏥]]></category>
		<category><![CDATA[❤️]]></category>
		<category><![CDATA[heart attack]]></category>
		<category><![CDATA[sTROKE]]></category>
		<category><![CDATA[stroke vs. heart attack]]></category>
		<category><![CDATA[what is the difference between heart attack and stroke?]]></category>
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					<description><![CDATA[What is the difference between heart attack and stroke? How are a stroke and heart attack different? stroke vs. heart attack Heart attack and stroke are both potentially life-threatening conditions that require emergency medical care. Both can cause permanent damage to important organs, affecting quality of life and even causing death. Though heart attack and stroke have several factors [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;">What is the difference between heart attack and stroke?</h1>
<h2 class="css-0" style="text-align: center;">How are a stroke and heart attack different?</h2>
<blockquote>
<h2 style="text-align: center;"><em><span style="color: #0000ff;">stroke</span> vs. <span style="color: #ff0000;">heart</span> <span style="color: #ff0000;">attack</span></em></h2>
</blockquote>
<div class="css-1u22pos">
<div>
<p class="css-dmtxcr">Heart attack and stroke are both potentially life-threatening conditions that require emergency medical care.</p>
</div>
<p>Both can cause permanent damage to important organs, affecting quality of life and even causing death.</p>
<p>Though heart attack and stroke have several factors in common, their symptoms, treatments, and recovery processes will differ.</p>
<p>In this article, we discuss these differences. Knowing them is vital for identifying and managing stroke and heart attack.</p>
</div>
<div class="css-0">
<div>Heart attack symptoms</div>
<div>
<figure class="css-4kegza"><span class="css-rwmw5v"><span class="css-8yl26h"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-11254" src="https://goodshepherdmedia.net/wp-content/uploads/2023/02/chest-pain-1024x683.webp" alt="" width="640" height="427" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/02/chest-pain-1024x683.webp 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/chest-pain-400x267.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/chest-pain-768x512.webp 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/chest-pain.webp 1100w" sizes="(max-width: 640px) 100vw, 640px" /></span></span></figure>
<figure class="css-4kegza"><figcaption class="css-1wtn3ae">Chest fullness and pressure could be symptoms of a heart attack.</figcaption></figure>
</div>
<p>Learning the warning signs of heart attack and stroke is important. Seek emergency medical care immediately if any symptoms appear.</p>
<p>Chest pain is one of most recognizable symptoms of a heart attack. While it is the most common symptom, many people who experience a heart attack have little to no chest pain.</p>
<p>These people may not realize that they are having a heart attack, and they may not seek medical care as quickly as needed.</p>
<p>Other symptoms that may indicate a heart attack include:</p>
<ul>
<li>a feeling of pressure, fullness, or squeezing in the chest</li>
<li>pain in the jaw, neck, arms, back, or stomach</li>
<li>feeling short of breath</li>
<li>lightheadedness or fainting</li>
<li>cold sweats</li>
<li>nausea or vomiting</li>
</ul>
<p>Women are more likely<span class="css-xi2i42 icon-hl-trusted-source-after"><span class="sro">Trusted Source</span></span> than men to experience nausea, vomiting, shortness of breath, and jaw pain during a heart attack.</p>
<p>Anyone who experiences these symptoms should seek care immediately.</p>
<div class="css-0">
<div>Stroke symptoms</div>
<p>There are two types of stroke: ischemic and hemorrhagic. Most people who have a stroke have an ischemic stroke. A blood clot in one of the brain’s blood vessels usually causes this.</p>
<p>A blockage or plaque does not cause hemorrhagic stroke. Instead, a burst artery can lead to this type of stroke.</p>
<p>A stroke can rapidly damage the brain, leading to permanent disability or death. Stroke symptoms begin quickly, often with no warning.</p>
<p>They may include:</p>
<ul>
<li>drooping on one side of the face, or being unable to move one side of the face</li>
<li>weakness or numbness in one arm, in which the person may be unable to raise both arms evenly out to the side</li>
<li>slurred speech or difficulty talking, during which the person may not be able to repeat simple words or sentences clearly</li>
<li>vision loss in one eye</li>
<li>loss of balance, frequent falling, or dizziness</li>
</ul>
<p>A transient ischemic attack (TIA), or mini-stroke, produces symptoms very similar to a stroke, but it only lasts for a few minutes. A TIA does not permanently damage the brain.</p>
<p>However, do not ignore them. Around 4 in 10 people who have a TIA will go on to have a stroke.</p>
<p>Anyone who experiences stroke symptoms should see a doctor immediately, even if they pass quickly.</p>
<p>&nbsp;</p>
</div>
<div class="css-0">
<div>Causes</div>
<div>
<figure class="css-4kegza"><span class="css-rwmw5v"><span class="css-8yl26h"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-11253" src="https://goodshepherdmedia.net/wp-content/uploads/2023/02/man-in-hospital-bed-comforted-by-woman-1024x683.webp" alt="" width="640" height="427" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/02/man-in-hospital-bed-comforted-by-woman-1024x683.webp 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/man-in-hospital-bed-comforted-by-woman-400x267.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/man-in-hospital-bed-comforted-by-woman-768x512.webp 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/man-in-hospital-bed-comforted-by-woman.webp 1100w" sizes="(max-width: 640px) 100vw, 640px" /></span></span></figure>
<figure class="css-4kegza"><figcaption class="css-1wtn3ae">A blood clot in the brain causes a stroke.</figcaption></figure>
</div>
<p>Atherosclerosis causes a buildup of plaque, a substance that restricts and hardens the blood vessels. This disease causes the majority of strokes and heart attacks.</p>
<p>Over time, the plaque can harden and break off, causing a blood clot to form. The clot can block the blood vessel and starve vital organs of oxygen.</p>
<p>During most heart attacks, a clot blocks a coronary artery, which is one of the heart’s blood vessels. Therefore, part of the heart muscle rapidly loses its blood supply and may incur permanent damage.</p>
<p>Similarly, most strokes are due to the blockage of a blood vessel somewhere in the brain. The clot robs the brain of its vital blood supply and can lead to brain damage.</p>
</div>
</div>
<div></div>
<div></div>
<div>
<div class="css-0">
<div>Treatment</div>
<p>Blocked arteries and blood clots can cause both heart attacks and strokes. So, their treatment may be similar in several ways.</p>
<p>In both conditions, a doctor may prescribe a person clot-busting medicines in the hospital. These medications are called thrombolytics, and they help dissolve the blood clot and restore blood flow to the affected organ.</p>
<p>Doctors usually need to administer thrombolytics as soon as possible after the symptoms begin, or at least within a few hours of onset.</p>
<p>Through an endovascular procedure, a specialist may also physically remove any blood clots in the coronary or carotid arteries. This is a nonsurgical procedure that uses a thin tube to grip the clot and remove it.</p>
<p>Examples of an endovascular procedure include:</p>
<ul>
<li>percutaneous coronary intervention for heart attack</li>
<li>mechanical thrombectomy for stroke</li>
</ul>
<p>Not everyone would benefit from a clot-removing procedure after a stroke or heart attack. If this surgery takes place, a specialist should perform it as soon as possible after symptoms become apparent.</p>
</div>
<div class="css-0">
<div>Recovery</div>
<p>After stroke or heart attack, doctors tend to prescribe certain medicines. These drugs can help by:</p>
<ul>
<li>reducing future plaque buildup in the arteries</li>
<li>lowering blood pressure or cholesterol</li>
<li>reducing blood clots</li>
</ul>
<p>Taking these medicines long-term may help a person prevent another heart attack or stroke.</p>
<p>Though some heart attack and stroke medicines may overlap, different treatments can help each condition. A doctor will base the particular medications they prescribe on a person’s medical history.</p>
<p>People who have had a heart attack might receive specific medicines that can help reduce stress on the heart, prevent further heart damage, and relieve chest pain.</p>
<p>People who have diabetes have higher risk of stroke, so a doctor might choose to prescribe medications to help regulate blood sugar to control this increased risk.</p>
<p>Many cases of stroke and heart attack are due to plaque buildup inside the arteries. For this reason, either condition may involve certain lifestyle changes, including:</p>
<ul>
<li>following a heart-healthy diet</li>
<li>getting regular exercise</li>
<li>quitting smoking</li>
<li>maintaining a healthy weight</li>
</ul>
<p>These changes can help the body recover from a stroke or heart attack and reduce the risk of having another, as well as promote general wellness.</p>
<p>The most important factor of good recovery from a heart attack or stroke is getting treatment as soon as possible.</p>
</div>
<div class="css-0">
<div>Differences in therapy</div>
<p>Recovery from many heart attacks and strokes requires some kind of rehabilitation or physical therapy. The type of therapy and the goals of the treatment are usually quite different between the two conditions.</p>
<h3>Therapy following a heart attack</h3>
<div>
<figure class="css-4kegza"><span class="css-rwmw5v"><span class="css-8yl26h"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-11255" src="https://goodshepherdmedia.net/wp-content/uploads/2023/02/exercise-after-heart-attack-1024x683.webp" alt="" width="640" height="427" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/02/exercise-after-heart-attack-1024x683.webp 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/exercise-after-heart-attack-400x267.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/exercise-after-heart-attack-768x512.webp 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/02/exercise-after-heart-attack.webp 1100w" sizes="(max-width: 640px) 100vw, 640px" /></span></span></figure>
<figure class="css-4kegza"><figcaption class="css-1wtn3ae">Doing heart-healthy, safe exercise can help a person recover from a heart attack.</figcaption></figure>
</div>
<p>After a heart attack, a person may require cardiac rehabilitation.</p>
<p>This is specialized therapy designed to improve heart health. A doctor supervises this treatment.</p>
<p>Cardiac rehabilitation usually includes:</p>
<ul>
<li><strong>Exercising:</strong> A cardiac rehabilitation specialist guides a person through exercise that is heart-healthy and safe for them to do.</li>
<li><strong>Receiving information about living a heart-healthy life:</strong> This includes adopting a healthful diet, quitting smoking, and managing heart attack risk factors.</li>
<li><strong>Reducing stress:</strong> Finding ways to manage stress can help improve heart health.</li>
</ul>
<h3>Therapy following a stroke</h3>
<p>Therapy after a stroke is quite different from rehabilitation after a heart attack.</p>
<p>If a person experiences brain damage during a stroke, therapy might include a variety of exercises to help a person regain physical and psychological functions they may have lost.</p>
<p>Most strokes cause one of the following disabilities, which may be temporary or permanent:</p>
<ul>
<li>problems with movement or paralysis in certain areas of the body</li>
<li>trouble swallowing</li>
<li>changes in behavior or emotions</li>
<li>problems with thinking and memory</li>
<li>trouble talking or understanding other people</li>
<li>uncontrolled urine leakage or bowel movements</li>
<li>changes to vision, taste, or smell</li>
</ul>
<p>Heart attack and stroke are similar in many ways, but each requires different care and follow-up.</p>
<p>Having a heart-healthy lifestyle and regularly visiting the doctor can help minimize the risk of these life-threatening conditions. However, it cannot prevent them entirely.</p>
<div id="widget_call_out_6374402f-1b03-4c30-ac99-78aa281e3ea7" class="css-crmikf">
<div class="css-10550dw">
<div class="css-jfhlvv">
<h3 class="css-4c0yvm"><span style="color: #0000ff;">Q:  How are heart attack and stroke different from heart failure?</span></h3>
</div>
<div>
<h3 class="css-4c0yvm"><span style="color: #ff6600;">A:  Heart attack and stroke are both acute conditions, while heart failure is a chronic condition. Heart attack occurs when blood flow to part of the heart is blocked, causing an insult to the heart muscle. Stroke, on the other hand, occurs when blood flow from part of the brain is cut off due to a blocked or ruptured blood vessel.</span></h3>
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<p>Medical professionals consider heart failure a progressive and chronic condition. With heart failure, the heart cannot pump enough blood effectively to meet the demands of the body.</p>
<p><cite>Gerhard Whitworth, RN</cite><span class="css-xi2i42 icon-hl-ribbon-after"><span class="sro">Trusted Source</span></span> <small>Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.</small></p>
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<p><a href="https://www.medicalnewstoday.com/articles/313958#Differences-in-therapy" target="_blank" rel="noopener">source</a></p>
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