<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:wfw="http://wellformedweb.org/CommentAPI/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	xmlns:sy="http://purl.org/rss/1.0/modules/syndication/"
	xmlns:slash="http://purl.org/rss/1.0/modules/slash/"
	>

<channel>
	<title>Sleep Archives - Good Shepherd News - Fastest Growing Religious, Free Speech &amp; Political Content</title>
	<atom:link href="https://goodshepherdmedia.net/tag/sleep/feed/" rel="self" type="application/rss+xml" />
	<link>https://goodshepherdmedia.net/tag/sleep/</link>
	<description>Christian, Political, ‎‏‏‎Social &#38; Legal Free Speech News &#124; Ⓒ2024 Good News Media LLC &#124; Shepherd for the Herd! God 1st Programming</description>
	<lastBuildDate>Sat, 20 Jan 2024 21:55:17 +0000</lastBuildDate>
	<language>en-US</language>
	<sy:updatePeriod>
	hourly	</sy:updatePeriod>
	<sy:updateFrequency>
	1	</sy:updateFrequency>
	<generator>https://wordpress.org/?v=7.0.2</generator>

<image>
	<url>https://goodshepherdmedia.net/wp-content/uploads/2023/08/Good-Shepherd-News-Logo-150x150.png</url>
	<title>Sleep Archives - Good Shepherd News - Fastest Growing Religious, Free Speech &amp; Political Content</title>
	<link>https://goodshepherdmedia.net/tag/sleep/</link>
	<width>32</width>
	<height>32</height>
</image> 
	<item>
		<title>Everything You Need To Know About Magnesium And Sleep</title>
		<link>https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Mon, 22 Jan 2024 20:31:33 +0000</pubDate>
				<category><![CDATA[⚠️Breaking News⚠️]]></category>
		<category><![CDATA[❤️Heart Health⚕️]]></category>
		<category><![CDATA[Biology]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[Herbs & Supplements]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Science & Engineering]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Women's Health]]></category>
		<category><![CDATA[🧠Brain Health🧠]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[🧬Bio-Hacking 101]]></category>
		<category><![CDATA[benefits of magnesium]]></category>
		<category><![CDATA[benifits of magnesium]]></category>
		<category><![CDATA[Magnesium]]></category>
		<category><![CDATA[Magnesium And Sleep]]></category>
		<category><![CDATA[Magnesium Sleep]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=17034</guid>

					<description><![CDATA[Everything You Need To Know About Magnesium And Sleep In the pecking order of natural sleep aids, magnesium seems to be steadily making its way to the top. This essential mineral plays multiple roles in the body, but what does it do for sleep? There is some evidence, both clinical and anecdotal, that magnesium may be helpful for [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 class="sleep-edu-blocks__page-title">Everything You Need To Know About Magnesium And Sleep</h1>
<p>In the pecking order of <a class="rank-math-link" href="https://sleepopolis.com/sleep-supplements/the-best-natural-sleep-aids/" target="_blank" rel="noopener">natural sleep aids</a>, <a class="rank-math-link" href="https://sleepopolis.com/news/magnesium-the-new-melatonin/" target="_blank" rel="noopener">magnesium</a> seems to be steadily making its way to the top. This essential mineral plays multiple roles in the body, but what does it do for sleep? There is some evidence, both clinical and anecdotal, that magnesium may be helpful for better sleep, but details are still murky. To get a better idea of how exactly magnesium and sleep could be connected, we spoke with a certified sleep expert and a registered nutritionist.</p>
<h2 id="what-is-magnesium-">What Is Magnesium?</h2>
<p>“Magnesium is a mineral we need in our diet to stay healthy,” explains Dr. Chelsie Rohrscheib, a neuroscientist and the head sleep expert at <a href="https://wesper.co/" target="_blank" rel="noopener">Wesper</a>. It’s classified as an electrolyte and involved in over 300 enzymatic processes in the body, including supporting bone health, regulating muscle function, and promoting energy production.</p>
<p>The body doesn’t make its own magnesium, which means we need to source sufficient amounts from the foods we eat or the supplements we take. The mineral is present in nutritious foods like fruits and vegetables, fish, nuts, seeds, legumes and whole grains. Still, a 2018 <a href="https://www.sciencedaily.com/releases/2018/02/180226122548.htm" target="_blank" rel="noopener">review</a> found that an estimated 50 percent of Americans may be deficient. While it’s not necessarily life threatening, a magnesium deficiency can have unpleasant <a href="https://www.ncbi.nlm.nih.gov/books/NBK500003/" target="_blank" rel="noopener">symptoms</a>, such as muscle cramps, tremors and twitches — none of which make it easy to fall or stay asleep.</p>
<h2 id="how-does-magnesium-affect-sleep-">How Does Magnesium Affect Sleep?</h2>
<p><a href="https://www.120life.com/pages/who-we-are" target="_blank" rel="noopener">Susan Schachte</a>r, MSRDN, calls magnesium a smooth muscle relaxer, which means it can help calm the nervous system. “It has been shown to increase levels of the neurotransmitter GABA, which helps calm the brain and reduce anxiety,” she explains. “Because of this, research has suggested that magnesium may help improve sleep quality, reduce insomnia, and increase sleep time in people with some sleep disorders.”</p>
<p>In fact, it’s often recommended to people who struggle with muscle cramps at night or those with <a class="rank-math-link" href="https://sleepopolis.com/education/restless-leg-syndrome/" target="_blank" rel="noopener">restless legs syndrome</a>, says Rohrscheib. But that’s not all.</p>
<p>“In addition to its involvement in reducing anxiety, relaxing muscle and increasing levels of GABA, magnesium helps to regulate the body’s production of <a class="rank-math-link" href="https://sleepopolis.com/education/melatonin-dosage-by-age-how-much-should-you-take/" target="_blank" rel="noopener">melatonin</a>, a hormone that’s important for sleep-wake cycles,” says Schachter.</p>
<p><img fetchpriority="high" decoding="async" class="alignnone size-full wp-image-17037" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-02.jpg" alt="" width="1000" height="387" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-02.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-02-400x155.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-02-768x297.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></p>
<p>While several small <a href="https://academic.oup.com/cdn/article/5/Supplement_2/1109/6292661" target="_blank" rel="noopener">studies</a> show a positive association between magnesium and improved sleep quality and duration, research about the actual impact of magnesium on sleep is still quite limited. What’s more, findings are mixed. A 2021 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053283/" target="_blank" rel="noopener">review</a> of magnesium supplementation for insomnia in older adults found that sleep latency and total sleep time improved, but researchers called the results statistically insignificant and noted that outcomes were supported with poor quality of evidence.</p>
<h3>How to Take Magnesium</h3>
<p>As a potential sleep aid, magnesium can be taken as an oral supplement about 30 minutes to an hour before bed. It comes in several forms, including magnesium oxide, magnesium citrate and magnesium chloride, and absorption can vary based on the type used in a given supplement. Some <a href="https://pubmed.ncbi.nlm.nih.gov/14596323/?dopt=Abstract" target="_blank" rel="noopener">studies</a> have found that <a href="https://www.mindbodygreen.com/articles/magnesium-dosage-for-sleep" target="_blank" rel="noopener">citrate</a> and chloride forms of magnesium are more bioavailable than oxide — that means the body is able to more readily absorb those forms, which could mean greater efficacy.</p>
<p>Magnesium is also available in topical form, including lotions, sprays, and bath salts. While research is still needed to confirm the efficacy of topical magnesium as a sleep remedy, the application of a soothing magnesium lotion or a calming soak in a warm tub could still be a good addition to a bedtime routine.</p>
<h2 id="how-much-magnesium-should-i-take-for-sleep-">How Much Magnesium Should I Take for Sleep?</h2>
<p>Keep in mind that we get magnesium in our diets, and it’s an essential mineral for various bodily functions. The <a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1" target="_blank" rel="noopener">National Institutes of Health</a> recommends that adults supplement with no more than 350 mg per day. That’s slightly at odds with dosages used in clinical studies of magnesium for sleep. “Some studies have shown that taking 200-400 mg before bed may help improve sleep quality and quantity, particularly in people who have difficulty falling asleep,” says Schachter.</p>
<p>Still, it’s best to err on the side of caution. “When supplementing one needs to be careful with dosing, as a high dose can cause diarrhea (because the intestines are smooth muscle) and/or upset stomach,” Schachter says.</p>
<h2 id="magnesium-and-anxiety">Magnesium and Anxiety</h2>
<p>There is <a href="https://www.mdpi.com/2072-6643/9/5/429" target="_blank" rel="noopener">research</a> that suggests magnesium could be a viable treatment for anxiety, possibly because of the way it regulates neurotransmitters and brain function. Specifically, magnesium interacts with stress mediators like the <a href="https://www.mdpi.com/2072-6643/12/12/3672" target="_blank" rel="noopener">hypothalamus</a>, the part of the brain that manages stress and anxiety, by inhibiting the stress response. However, like magnesium as a sleep aid, more research is needed to clarify how exactly magnesium can help with anxiety.</p>
<h2 id="how-can-i-raise-my-magnesium-levels-naturally-">How Can I Raise My Magnesium Levels Naturally?</h2>
<p>Generally, you can increase magnesium levels through diet alone, because it’s present in a fairly wide range of foods. The federal government’s <a href="https://www.dietaryguidelines.gov/" target="_blank" rel="noopener">Dietary Guidelines for Americans</a> outlines a healthy diet as one that includes a mix of vegetables, fat and low-fat dairy, beans and legumes, and nuts and seeds, all of which include magnesium.</p>
<h3>Foods High In Magnesium</h3>
<p>Schachter says that the amount of magnesium in specific foods can vary depending on how they’re processed and prepared, but the following are great sources:</p>
<ul>
<li>Dark leafy greens: spinach, kale, Swiss chard, collard greens</li>
<li>Nuts and seeds: almonds, cashews, pumpkin seeds, sunflower seeds</li>
<li>Legumes: black beans, kidney beans, chickpeas, lentils</li>
<li>Whole grains: brown rice, quinoa (actually a seed but used like a grain), whole wheat products</li>
<li>Fish: halibut, salmon, mackerel</li>
<li>Dairy products: milk, yogurt, cheese</li>
<li>Soy Products: soy milk, soy beans</li>
<li>Dark chocolate</li>
</ul>
<p><img decoding="async" class="alignnone size-full wp-image-17038" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-01.jpg" alt="" width="1000" height="1404" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-01.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-01-285x400.jpg 285w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-01-729x1024.jpg 729w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-01-768x1078.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></p>
<h2 id="is-magnesium-better-than-melatonin-">Is Magnesium Better Than Melatonin?</h2>
<p>Magnesium is inherently different from melatonin. One is an essential mineral that we need to source from the foods we eat, while the other is a hormone that we produce naturally. Schachter says they can both potentially help with sleep, and the two substances share a deeper connection as well. “Magnesium has the benefit of helping with melatonin production, as well as decreasing anxiety and relaxing muscles,” she says.</p>
<figure class="wp-block-image size-full"><img decoding="async" class="alignnone size-full wp-image-17039" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-03.jpg" alt="" width="1000" height="387" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-03.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-03-400x155.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-03-768x297.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></figure>
<p>It isn’t that one is necessarily better than the other, but rather that they offer different benefits. Melatonin supplements help jumpstart your natural melatonin production, which can make it easier to fall asleep in certain scenarios, like if you’re dealing with jet lag, trying to sleep in a new environment, or navigating short-term insomnia. Magnesium can be a better option if you need to shut down an anxious mind so that your body can relax into sleep.</p>
<figure class="wp-block-image size-full"><img loading="lazy" decoding="async" class="alignnone size-full wp-image-17040" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-04.jpg" alt="" width="1000" height="387" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-04.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-04-400x155.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/Foods-with-Magnesium-04-768x297.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></figure>
<h2 id="the-last-word-from-sleepopolis-"><strong>The Last Word from Sleepopolis</strong></h2>
<p>Magnesium rivals melatonin as a popular natural sleep aid, and there is promising research to support its role in better sleep. However, more studies are needed to pinpoint exactly how magnesium supports sleep. If you’re considering this supplement to help you get a better night’s sleep, make sure to speak with your doctor first. “It’s always important to check with a healthcare professional to be sure magnesium is safe for you if you have any health conditions or are taking medication,” says Schachter. <a href="https://sleepopolis.com/education/magnesium-and-sleep/" target="_blank" rel="noopener">source</a></p>
<hr />
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<hr />
<p>&nbsp;</p>
<p><img loading="lazy" decoding="async" class=" wp-image-17036 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-400x301.jpg" alt="" width="302" height="227" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-400x301.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-1024x771.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-768x578.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-1536x1156.jpg 1536w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/CSIRO_ScienceImage_2893_Crystalised_magnesium-2048x1541.jpg 2048w" sizes="(max-width: 302px) 100vw, 302px" /></p>
<h2 id="h1">Magnesium Introduction</h2>
<p>Magnesium, an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1-3</a>]. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>].</p>
<p>An adult body contains approximately 25 g magnesium, with 50% to 60% present in the bones and most of the rest in soft tissues [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en4">4</a>]. Less than 1% of total magnesium is in blood serum, and these levels are kept under tight control. Normal serum magnesium concentrations range between 0.75 and 0.95 millimoles (mmol)/L [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en5">5</a>]. Hypomagnesemia is defined as a serum magnesium level less than 0.75 mmol/L [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en6">6</a>]. Magnesium homeostasis is largely controlled by the kidney, which typically excretes about 120 mg magnesium into the urine each day [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>]. Urinary excretion is reduced when magnesium status is low [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>].</p>
<p>Assessing magnesium status is difficult because most magnesium is inside cells or in bone [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>]. The most commonly used and readily available method for assessing magnesium status is measurement of serum magnesium concentration, even though serum levels have little correlation with total body magnesium levels or concentrations in specific tissues [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en6">6</a>]. Other methods for assessing magnesium status include measuring magnesium concentrations in erythrocytes, saliva, and urine; measuring ionized magnesium concentrations in blood, plasma, or serum; and conducting a magnesium-loading (or tolerance) test. No single method is considered satisfactory [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en7">7</a>]. Some experts [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en4">4</a>] but not others [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>] consider the tolerance test (in which urinary magnesium is measured after parenteral infusion of a dose of magnesium) to be the best method to assess magnesium status in adults. To comprehensively evaluate magnesium status, both laboratory tests and a clinical assessment might be required [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en6">6</a>].</p>
<h2 id="h2">Recommended Intakes</h2>
<p>Intake recommendations for magnesium and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the Institute of Medicine of the National Academies (formerly National Academy of Sciences) [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. DRI is the general term for a set of reference values used to plan and assess nutrient intakes of healthy people. These values, which vary by age and sex, include the following:</p>
<ul>
<li>Recommended Dietary Allowance (RDA): Average daily level of intake sufficient to meet the nutrient requirements of nearly all (97%–98%) healthy individuals; often used to plan nutritionally adequate diets for individuals</li>
<li>Adequate Intake (AI): Intake at this level is assumed to ensure nutritional adequacy; established when evidence is insufficient to develop an RDA</li>
<li>Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals</li>
<li>Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects</li>
</ul>
<p>Table 1 lists the current RDAs for magnesium [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. For infants from birth to 12 months, the FNB established an AI for magnesium that is equivalent to the mean intake of magnesium in healthy, breastfed infants, with added solid foods for ages 7–12 months.</p>
<table border="1">
<caption>Table 1: Recommended Dietary Allowances (RDAs) for Magnesium [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]</caption>
<thead>
<tr>
<th scope="col">Age</th>
<th scope="col">Male</th>
<th scope="col">Female</th>
<th scope="col">Pregnancy</th>
<th scope="col">Lactation</th>
</tr>
</thead>
<tbody>
<tr>
<td scope="row">Birth to 6 months</td>
<td align="right">30 mg*</td>
<td align="right">30 mg*</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">7–12 months</td>
<td align="right">75 mg*</td>
<td align="right">75 mg*</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">1–3 years</td>
<td align="right">80 mg</td>
<td align="right">80 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">4–8 years</td>
<td align="right">130 mg</td>
<td align="right">130 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">9–13 years</td>
<td align="right">240 mg</td>
<td align="right">240 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">14–18 years</td>
<td align="right">410 mg</td>
<td align="right">360 mg</td>
<td align="right">400 mg</td>
<td align="right">360 mg</td>
</tr>
<tr>
<td scope="row">19–30 years</td>
<td align="right">400 mg</td>
<td align="right">310 mg</td>
<td align="right">350 mg</td>
<td align="right">310 mg</td>
</tr>
<tr>
<td scope="row">31–50 years</td>
<td align="right">420 mg</td>
<td align="right">320 mg</td>
<td align="right">360 mg</td>
<td align="right">320 mg</td>
</tr>
<tr>
<td scope="row">51+ years</td>
<td align="right">420 mg</td>
<td align="right">320 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
</tbody>
</table>
<h2 id="h3">Sources of Magnesium</h2>
<h3>Food</h3>
<p>Magnesium is widely distributed in plant and animal foods and in beverages. Green leafy vegetables, such as spinach, legumes, nuts, seeds, and whole grains, are good sources [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>]. In general, foods containing dietary fiber provide magnesium. Magnesium is also added to some breakfast cereals and other fortified foods. Some types of food processing, such as refining grains in ways that remove the nutrient-rich germ and bran, lower magnesium content substantially [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. Selected food sources of magnesium are listed in Table 2.</p>
<p>Tap, mineral, and bottled waters can also be sources of magnesium, but the amount of magnesium in water varies by source and brand (ranging from 1 mg/L to more than 120 mg/L) [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en8">8</a>].</p>
<p>Approximately 30% to 40% of the dietary magnesium consumed is typically absorbed by the body [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en9">9</a>].</p>
<table border="1">
<caption>Table 2: Magnesium Content of Selected Foods [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en10">10</a>]</caption>
<thead>
<tr>
<th scope="col">Food</th>
<th scope="col">Milligrams<br />
(mg) per<br />
serving</th>
<th scope="col">Percent<br />
DV*</th>
</tr>
</thead>
<tbody>
<tr>
<td scope="row">Pumpkin seeds, roasted, 1 ounce</td>
<td align="right">156</td>
<td align="right">37</td>
</tr>
<tr>
<td scope="row">Chia seeds, 1 ounce</td>
<td align="right">111</td>
<td align="right">26</td>
</tr>
<tr>
<td scope="row">Almonds, dry roasted, 1 ounce</td>
<td align="right">80</td>
<td align="right">19</td>
</tr>
<tr>
<td scope="row">Spinach, boiled, ½ cup</td>
<td align="right">78</td>
<td align="right">19</td>
</tr>
<tr>
<td scope="row">Cashews, dry roasted, 1 ounce</td>
<td align="right">74</td>
<td align="right">18</td>
</tr>
<tr>
<td scope="row">Peanuts, oil roasted, ¼ cup</td>
<td align="right">63</td>
<td align="right">15</td>
</tr>
<tr>
<td scope="row">Cereal, shredded wheat, 2 large biscuits</td>
<td align="right">61</td>
<td align="right">15</td>
</tr>
<tr>
<td scope="row">Soymilk, plain or vanilla, 1 cup</td>
<td align="right">61</td>
<td align="right">15</td>
</tr>
<tr>
<td scope="row">Black beans, cooked, ½ cup</td>
<td align="right">60</td>
<td align="right">14</td>
</tr>
<tr>
<td scope="row">Edamame, shelled, cooked, ½ cup</td>
<td align="right">50</td>
<td align="right">12</td>
</tr>
<tr>
<td scope="row">Peanut butter, smooth, 2 tablespoons</td>
<td align="right">49</td>
<td align="right">12</td>
</tr>
<tr>
<td scope="row">Potato, baked with skin, 3.5 ounces</td>
<td align="right">43</td>
<td align="right">10</td>
</tr>
<tr>
<td scope="row">Rice, brown, cooked, ½ cup</td>
<td align="right">42</td>
<td align="right">10</td>
</tr>
<tr>
<td scope="row">Yogurt, plain, low fat, 8 ounces</td>
<td align="right">42</td>
<td align="right">10</td>
</tr>
<tr>
<td scope="row">Breakfast cereals, fortified with 10% of the DV for magnesium, 1 serving</td>
<td align="right">42</td>
<td align="right">10</td>
</tr>
<tr>
<td scope="row">Oatmeal, instant, 1 packet</td>
<td align="right">36</td>
<td align="right">9</td>
</tr>
<tr>
<td scope="row">Kidney beans, canned, ½ cup</td>
<td align="right">35</td>
<td align="right">8</td>
</tr>
<tr>
<td scope="row">Banana, 1 medium</td>
<td align="right">32</td>
<td align="right">8</td>
</tr>
<tr>
<td scope="row">Salmon, Atlantic, farmed, cooked, 3 ounces</td>
<td align="right">26</td>
<td align="right">6</td>
</tr>
<tr>
<td scope="row">Milk, 1 cup</td>
<td align="right">24–27</td>
<td align="right">6</td>
</tr>
<tr>
<td scope="row">Halibut, cooked, 3 ounces</td>
<td align="right">24</td>
<td align="right">6</td>
</tr>
<tr>
<td scope="row">Raisins, ½ cup</td>
<td align="right">23</td>
<td align="right">5</td>
</tr>
<tr>
<td scope="row">Bread, whole wheat, 1 slice</td>
<td align="right">23</td>
<td align="right">5</td>
</tr>
<tr>
<td scope="row">Avocado, cubed, ½ cup</td>
<td align="right">22</td>
<td align="right">5</td>
</tr>
<tr>
<td scope="row">Chicken breast, roasted, 3 ounces</td>
<td align="right">22</td>
<td align="right">5</td>
</tr>
<tr>
<td scope="row">Beef, ground, 90% lean, pan broiled, 3 ounces</td>
<td align="right">20</td>
<td align="right">5</td>
</tr>
<tr>
<td scope="row">Broccoli, chopped and cooked, ½ cup</td>
<td align="right">12</td>
<td align="right">3</td>
</tr>
<tr>
<td scope="row">Rice, white, cooked, ½ cup</td>
<td align="right">10</td>
<td align="right">2</td>
</tr>
<tr>
<td scope="row">Apple, 1 medium</td>
<td align="right">9</td>
<td align="right">2</td>
</tr>
<tr>
<td scope="row">Carrot, raw, 1 medium</td>
<td align="right">7</td>
<td align="right">2</td>
</tr>
</tbody>
</table>
<p>*DV = Daily Value. The U.S. Food and Drug Administration (FDA) developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet. The DV for magnesium is 420 mg for adults and children age 4 years and older [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en11">11</a>]. FDA does not require food labels to list magnesium content unless magnesium has been added to the food. Foods providing 20% or more of the DV are considered to be high sources of a nutrient, but foods providing lower percentages of the DV also contribute to a healthful diet.</p>
<p>The U.S. Department of Agriculture’s (USDA’s) <a href="https://fdc.nal.usda.gov/" target="external" rel="noopener">FoodData Central</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a> [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en10">10</a>] lists the nutrient content of many foods and provides comprehensive list of foods containing magnesium arranged by <a href="https://ods.od.nih.gov/pubs/usdandb/Magnesium-Content.pdf">nutrient content</a> and by <a href="https://ods.od.nih.gov/pubs/usdandb/Magnesium-Food.pdf">food name</a>.</p>
<h3>Dietary supplements</h3>
<p>Magnesium supplements are available in a variety of forms, including magnesium oxide, citrate, and chloride [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>]. The Supplement Facts panel on a dietary supplement label declares the amount of elemental magnesium in the product, not the weight of the entire magnesium-containing compound.</p>
<p>Absorption of magnesium from different kinds of magnesium supplements varies. Forms of magnesium that dissolve well in liquid are more completely absorbed in the gut than less soluble forms [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en12">12</a>]. Small studies have found that magnesium in the aspartate, citrate, lactate, and chloride forms is absorbed more completely and is more bioavailable than magnesium oxide and magnesium sulfate [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en12">12-16</a>]. One study found that very high doses of zinc from supplements (142 mg/day) can interfere with magnesium absorption and disrupt the magnesium balance in the body [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en17">17</a>].</p>
<h3>Medicines</h3>
<p>Magnesium is a primary ingredient in some laxatives [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en18">18</a>]. Phillips’ Milk of Magnesia, for example, provides 500 mg elemental magnesium (as magnesium hydroxide) per tablespoon; the directions advise taking up to 4 tablespoons/day for adolescents and adults [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en19">19</a>]. (Although such a dose of magnesium is well above the safe upper level, some of the magnesium is not absorbed because of the medication’s laxative effect.) Magnesium is also included in some remedies for heartburn and upset stomach due to acid indigestion [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en18">18</a>]. Extra-strength Rolaids, for example, provides 55 mg elemental magnesium (as magnesium hydroxide) per tablet [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en20">20</a>], although Tums is magnesium free [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en21">21</a>].</p>
<h2 id="h7">Magnesium Intakes and Status</h2>
<p>Dietary surveys of people in the United States consistently show that many people consume less than recommended amounts of magnesium. An analysis of data from the National Health and Nutrition Examination Survey (NHANES) of 2013–2016 found that 48% of Americans of all ages ingest less magnesium from food and beverages than their respective EARs; adult men age 71 years and older and adolescent males and females are most likely to have low intakes [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en22">22</a>]. In a study using data from NHANES 2003–2006 to assess mineral intakes among adults, average intakes of magnesium from food alone were higher among users of dietary supplements (350 mg for men and 267 mg for women, equal to or slightly exceeding their respective EARs) than among nonusers (268 mg for men and 234 for women) [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en23">23</a>]. When supplements were included, average total intakes of magnesium were 449 mg for men and 387 mg for women, well above EAR levels.</p>
<p>No current data on magnesium status in the United States are available. Determining dietary intake of magnesium is the usual proxy for assessing magnesium status. NHANES has not determined serum magnesium levels in its participants since 1974 [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en24">24</a>], and magnesium is not evaluated in routine electrolyte testing in hospitals and clinics [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>].</p>
<h2 id="h8">Magnesium Deficiency</h2>
<p>Symptomatic magnesium deficiency due to low dietary intake in otherwise-healthy people is uncommon because the kidneys limit urinary excretion of this mineral [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>]. However, habitually low intakes or excessive losses of magnesium due to certain health conditions, chronic alcoholism, and/or the use of certain medications can lead to magnesium deficiency.</p>
<p>Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>]. Severe magnesium deficiency can result in hypocalcemia or hypokalemia (low serum calcium or potassium levels, respectively) because mineral homeostasis is disrupted [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>].</p>
<h2 id="h9">Groups at Risk of Magnesium Inadequacy</h2>
<p>Magnesium inadequacy can occur when intakes fall below the RDA but are above the amount required to prevent overt deficiency. The following groups are more likely than others to be at risk of magnesium inadequacy because they typically consume insufficient amounts or they have medical conditions (or take medications) that reduce magnesium absorption from the gut or increase losses from the body.</p>
<h3>People with gastrointestinal diseases</h3>
<p>The chronic diarrhea and fat malabsorption resulting from Crohn’s disease, gluten-sensitive enteropathy (celiac disease), and regional enteritis can lead to magnesium depletion over time [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>]. Resection or bypass of the small intestine, especially the ileum, typically leads to malabsorption and magnesium loss [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>].</p>
<h3>People with type 2 diabetes</h3>
<p>Magnesium deficits and increased urinary magnesium excretion can occur in people with insulin resistance and/or type 2 diabetes [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en25">25</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en26">26</a>]. The magnesium loss appears to be secondary to higher concentrations of glucose in the kidney that increase urine output [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>].</p>
<h3>People with alcohol dependence</h3>
<p>Magnesium deficiency is common in people with chronic alcoholism [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>]. In these individuals, poor dietary intake and nutritional status; gastrointestinal problems, including vomiting, diarrhea, and steatorrhea (fatty stools) resulting from pancreatitis; renal dysfunction with excess excretion of magnesium into the urine; phosphate depletion; vitamin D deficiency; acute alcoholic ketoacidosis; and hyperaldosteronism secondary to liver disease can all contribute to decreased magnesium status [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en2">2</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en27">27</a>].</p>
<h3>Older adults</h3>
<p>Older adults have lower dietary intakes of magnesium than younger adults [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en21">21</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en28">28</a>]. In addition, magnesium absorption from the gut decreases and renal magnesium excretion increases with age [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en29">29</a>]. Older adults are also more likely to have chronic diseases or take medications that alter magnesium status, which can increase their risk of magnesium depletion [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en30">30</a>].</p>
<h2 id="h14">Magnesium and Health</h2>
<p>Habitually low intakes of magnesium induce changes in biochemical pathways that can increase the risk of illness over time. This section focuses on four diseases and disorders in which magnesium might be involved: hypertension and cardiovascular disease, type 2 diabetes, osteoporosis, and migraine headaches.</p>
<h3>Hypertension and cardiovascular disease</h3>
<p>Hypertension is a major risk factor for heart disease and stroke. Studies to date, however, have found that magnesium supplementation lowers blood pressure, at best, to only a small extent. A meta-analysis of 12 clinical trials found that magnesium supplementation for 8–26 weeks in 545 hypertensive participants resulted in only a small reduction (2.2 mmHg) in diastolic blood pressure [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en31">31</a>]. The dose of magnesium ranged from approximately 243 to 973 mg/day. The authors of another meta-analysis of 22 studies with 1,173 normotensive and hypertensive adults concluded that magnesium supplementation for 3–24 weeks decreased systolic blood pressure by 3–4 mmHg and diastolic blood pressure by 2–3 mmHg [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en32">32</a>]. The effects were somewhat larger when supplemental magnesium intakes of the participants in the nine crossover-design trials exceeded 370 mg/day. A diet containing more magnesium because of added fruits and vegetables, more low-fat or nonfat dairy products, and less fat overall was shown to lower systolic and diastolic blood pressure by an average of 5.5 and 3.0 mmHg, respectively [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en33">33</a>]. However, this Dietary Approaches to Stop Hypertension (DASH) diet also increases intakes of other nutrients, such as potassium and calcium, that are associated with reductions in blood pressure, so any independent contribution of magnesium cannot be determined.</p>
<p>In 2022, FDA approved a qualified health claim for conventional foods and dietary supplements that contain magnesium [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en34">34</a>]. One example of this claim states, “Consuming diets with adequate magnesium may reduce the risk of high blood pressure (hypertension). However, FDA has concluded that the evidence is inconsistent and inconclusive.” FDA also specifies that foods and dietary supplements carrying this claim on their labels must provide at least 84 mg of magnesium per serving and, for dietary supplements, no more than 350 mg.</p>
<p>Several prospective studies have examined associations between magnesium intakes and heart disease. The Atherosclerosis Risk in Communities study assessed heart disease risk factors and levels of serum magnesium in a cohort of 14,232 White and African-American men and women age 45 to 64 years at baseline [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en35">35</a>]. Over an average of 12 years of follow-up, individuals in the highest quartile of the normal physiologic range of serum magnesium (at least 0.88 mmol/L) had a 38% reduced risk of sudden cardiac death compared with individuals in the lowest quartile (0.75 mmol/L or less). However, dietary magnesium intakes had no association with risk of sudden cardiac death. Another prospective study tracked 88,375 female nurses in the United States to determine whether serum magnesium levels measured early in the study and magnesium intakes from food and supplements assessed every 2 to 4 years were associated with sudden cardiac death over 26 years of follow-up [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en36">36</a>]. Women in the highest compared with the lowest quartile of ingested and plasma magnesium concentrations had a 34% and 77% lower risk of sudden cardiac death, respectively. Another prospective population study of 7,664 adults age 20 to 75 years in the Netherlands who did not have cardiovascular disease found that low urinary magnesium excretion levels (a marker for low dietary magnesium intake) were associated with a higher risk of ischemic heart disease over a median follow-up period of 10.5 years. Plasma magnesium concentrations were not associated with risk of ischemic heart disease [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en37">37</a>]. A systematic review and meta-analysis of prospective studies found that higher serum levels of magnesium were significantly associated with a lower risk of cardiovascular disease, and higher dietary magnesium intakes (up to approximately 250 mg/day) were associated with a significantly lower risk of ischemic heart disease caused by a reduced blood supply to the heart muscle [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en38">38</a>].</p>
<p>Higher magnesium intakes might reduce the risk of stroke. In a meta-analysis of seven prospective trials with a total of 241,378 participants, an additional 100 mg/day magnesium in the diet was associated with an 8% decreased risk of total stroke, especially ischemic rather than hemorrhagic stroke [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en39">39</a>]. One limitation of such observational studies, however, is the possibility of confounding with other nutrients or dietary components that could also affect the risk of stroke.</p>
<p>A large, well-designed clinical trial is needed to better understand the contributions of magnesium from food and dietary supplements to heart health and the primary prevention of cardiovascular disease [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en40">40</a>].</p>
<h3>Type 2 diabetes</h3>
<p>Diets with higher amounts of magnesium are associated with a significantly lower risk of diabetes, possibly because of the important role of magnesium in glucose metabolism [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en41">41</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en42">42</a>]. Hypomagnesemia might worsen insulin resistance, a condition that often precedes diabetes, or it might be a consequence of insulin resistance [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en43">43</a>]. Diabetes leads to increased urinary losses of magnesium, and the subsequent magnesium inadequacy might impair insulin secretion and action, thereby worsening diabetes control [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en3">3</a>].</p>
<p>Most investigations of magnesium intake and risk of type 2 diabetes have been prospective cohort studies. A meta-analysis of seven of these studies, which included 286,668 patients and 10,912 cases of diabetes over 6 to 17 years of follow-up, found that a 100 mg/day increase in total magnesium intake decreased the risk of diabetes by a statistically significant 15% [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en41">41</a>]. Another meta-analysis of eight prospective cohort studies that followed 271,869 men and women over 4 to 18 years found a significant inverse association between magnesium intake from food and risk of type 2 diabetes; the relative risk reduction was 23% when the highest to lowest intakes were compared [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en44">44</a>].</p>
<p>A 2011 meta-analysis of prospective cohort studies of the association between magnesium intake and risk of type 2 diabetes included 13 studies with a total of 536,318 participants and 24,516 cases of diabetes [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en45">45</a>]. The mean length of follow-up ranged from 4 to 20 years. Investigators found an inverse association between magnesium intake and risk of type 2 diabetes in a dose-responsive fashion, but this association achieved statistical significance only in individuals who were overweight (body mass index [BMI] 25 or higher) but not in normal-weight individuals (BMI less than 25). Again, a limitation of these observational studies is the possibility of confounding with other dietary components or lifestyle or environmental variables that are correlated with magnesium intake.</p>
<p>Only a few small, short-term clinical trials have examined the potential effects of supplemental magnesium on control of type 2 diabetes and the results are conflicting [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en42">42</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en46">46</a>]. For example, 128 patients with poorly controlled diabetes in a Brazilian clinical trial received a placebo or a supplement containing either 500 mg/day or 1,000 mg/day magnesium oxide (providing 300 or 600 mg elemental magnesium, respectively) [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en47">47</a>]. After 30 days of supplementation, plasma, cellular, and urine magnesium levels increased in participants receiving the larger dose of the supplement, and their glycemic control improved. In another small trial in Mexico, participants with type 2 diabetes and hypomagnesemia who received a liquid supplement of magnesium chloride (providing 300 mg/day elemental magnesium) for 16 weeks showed significant reductions in fasting glucose and glycosylated hemoglobin concentrations compared with participants receiving a placebo, and their serum magnesium levels became normal [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en48">48</a>]. In contrast, neither a supplement of magnesium aspartate (providing 369 mg/day elemental magnesium) nor a placebo taken for 3 months had any effect on glycemic control in 50 patients with type 2 diabetes who were taking insulin [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en49">49</a>].</p>
<p>The American Diabetes Association states that there is insufficient evidence to support the routine use of magnesium to improve glycemic control in people with diabetes [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en46">46</a>]. It further notes that there is no clear scientific evidence that vitamin and mineral supplementation benefits people with diabetes who do not have underlying nutritional deficiencies.</p>
<h3>Osteoporosis</h3>
<p>Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en50">50</a>]. Magnesium also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Several population-based studies have found positive associations between magnesium intake and bone mineral density in both men and women [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en51">51</a>]. Other research has found that women with osteoporosis have lower serum magnesium levels than women with osteopenia and those who do not have osteoporosis or osteopenia [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en52">52</a>]. These and other findings indicate that magnesium deficiency might be a risk factor for osteoporosis [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en50">50</a>].</p>
<p>Although limited in number, studies suggest that increasing magnesium intakes from food or supplements might increase bone mineral density in postmenopausal and elderly women [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. For example, one short-term study found that 290 mg/day elemental magnesium (as magnesium citrate) for 30 days in 20 postmenopausal women with osteoporosis suppressed bone turnover compared with placebo, suggesting that bone loss decreased [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en53">53</a>].</p>
<p>Diets that provide recommended levels of magnesium enhance bone health, but further research is needed to elucidate the role of magnesium in the prevention and management of osteoporosis.</p>
<h3>Migraine headaches</h3>
<p>Magnesium deficiency is related to factors that promote headaches, including neurotransmitter release and vasoconstriction [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en54">54</a>]. People who experience migraine headaches have lower levels of serum and tissue magnesium than those who do not.</p>
<p>However, research on the use of magnesium supplements to prevent or reduce symptoms of migraine headaches is limited. Three of four small, short-term, placebo-controlled trials found modest reductions in the frequency of migraines in patients given up to 600 mg/day magnesium [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en54">54</a>]. The authors of a review on migraine prophylaxis suggested that taking 300 mg magnesium twice a day, either alone or in combination with medication, can prevent migraines [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en55">55</a>].</p>
<p>In their evidence-based guideline update, the American Academy of Neurology and the American Headache Society concluded that magnesium therapy is probably effective for migraine prevention [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en56">56</a>]. Because the typical dose of magnesium used for migraine prevention exceeds the UL, this treatment should be used only under the direction and supervision of a health care provider.</p>
<h2 id="h19">Health Risks from Excessive Magnesium</h2>
<p>Too much magnesium from food does not pose a health risk in healthy individuals because the kidneys eliminate excess amounts in the urine [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en29">29</a>]. However, high doses of magnesium from dietary supplements or medications often result in diarrhea that can be accompanied by nausea and abdominal cramping [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. Forms of magnesium most commonly reported to cause diarrhea include magnesium carbonate, chloride, gluconate, and oxide [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en12">12</a>]. The diarrhea and laxative effects of magnesium salts are due to the osmotic activity of unabsorbed salts in the intestine and colon and the stimulation of gastric motility [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en57">57</a>].</p>
<p>Very large doses of magnesium-containing laxatives and antacids (typically providing more than 5,000 mg/day magnesium) have been associated with magnesium toxicity [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en58">58</a>], including fatal hypermagnesemia in a 28-month-old boy [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en59">59</a>] and an elderly man [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en60">60</a>]. Symptoms of magnesium toxicity, which usually develop after serum concentrations exceed 1.74–2.61 mmol/L, can include hypotension, nausea, vomiting, facial flushing, retention of urine, ileus, depression, and lethargy before progressing to muscle weakness, difficulty breathing, extreme hypotension, irregular heartbeat, and cardiac arrest [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en29">29</a>]. The risk of magnesium toxicity increases with impaired renal function or kidney failure because the ability to remove excess magnesium is reduced or lost [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en29">29</a>].</p>
<p>The FNB has established ULs for supplemental magnesium for healthy infants, children, and adults (see Table 3) [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]. For many age groups, the UL appears to be lower than the RDA. This occurs because the RDAs include magnesium from all sources—food, beverages, dietary supplements, and medications. The ULs include magnesium from only dietary supplements and medications; they do not include magnesium found naturally in food and beverages.</p>
<table border="1">
<caption>Table 3: Tolerable Upper Intake Levels (ULs) for Supplemental Magnesium [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en1">1</a>]</caption>
<thead>
<tr>
<th scope="col">Age</th>
<th scope="col">Male</th>
<th scope="col">Female</th>
<th scope="col">Pregnant</th>
<th scope="col">Lactating</th>
</tr>
</thead>
<tbody>
<tr>
<td scope="row">Birth to 12 months</td>
<td align="right">None established</td>
<td align="right">None established</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">1–3 years</td>
<td align="right">65 mg</td>
<td align="right">65 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">4–8 years</td>
<td align="right">110 mg</td>
<td align="right">110 mg</td>
<td align="right"></td>
<td align="right"></td>
</tr>
<tr>
<td scope="row">9–18 years</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
</tr>
<tr>
<td scope="row">19+ years</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
<td align="right">350 mg</td>
</tr>
</tbody>
</table>
<p>&nbsp;</p>
<h2 id="h20">Interactions with Medications</h2>
<p>Several types of medications have the potential to interact with magnesium supplements or affect magnesium status. A few examples are provided below. People taking these and other medications on a regular basis should discuss their magnesium intakes with their health care providers.</p>
<h3>Bisphosphonates</h3>
<p>Magnesium-rich supplements or medications can decrease the absorption of oral bisphosphonates, such as alendronate (Fosamax), used to treat osteoporosis [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en61">61</a>]. Use of magnesium-rich supplements or medications and oral bisphosphonates should be separated by at least 2 hours [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en57">57</a>].</p>
<h3>Antibiotics</h3>
<p>Magnesium can form insoluble complexes with tetracyclines, such as demeclocycline (Declomycin) and doxycycline (Vibramycin) as well as quinolone antibiotics, such as ciprofloxacin (Cipro) and levofloxacin (Levaquin). These antibiotics should be taken at least 2 hours before or 4–6 hours after a magnesium-containing supplement [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en57">57</a>,<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en62">62</a>].</p>
<h3>Diuretics</h3>
<p>Chronic treatment with loop diuretics, such as furosemide (Lasix) and bumetanide (Bumex), and thiazide diuretics, such as hydrochlorothiazide (Aquazide H) and ethacrynic acid (Edecrin), can increase the loss of magnesium in urine and lead to magnesium depletion [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en63">63</a>]. In contrast, potassium-sparing diuretics, such as amiloride (Midamor) and spironolactone (Aldactone), reduce magnesium excretion [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en63">63</a>].</p>
<h3>Proton pump inhibitors</h3>
<p>Prescription proton pump inhibitor (PPI) drugs, such as esomeprazole magnesium (Nexium) and lansoprazole (Prevacid), when taken for prolonged periods (typically more than a year) can cause hypomagnesemia [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en64">64</a>]. In cases that FDA reviewed, magnesium supplements often raised the low serum magnesium levels caused by PPIs. However, in 25% of the cases, supplements did not raise magnesium levels and the patients had to discontinue the PPI. FDA advises health care professionals to consider measuring patients’ serum magnesium levels prior to initiating long-term PPI treatment and to check magnesium levels in these patients periodically [<a class="fscopy_nounderline" href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#en64">64</a>].</p>
<h2 id="h25">Magnesium and Healthful Diets</h2>
<p>The federal government’s 2020–2025 <em>Dietary Guidelines for Americans</em> notes that “Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. … In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy).”</p>
<p>For more information about building a healthy dietary pattern, refer to the <em><a href="https://www.dietaryguidelines.gov/" target="external" rel="noopener">Dietary Guidelines for Americans</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a></em> and the USDA’s <em><a href="https://www.choosemyplate.gov/" target="external" rel="noopener">MyPlate.</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a></em></p>
<p>The <em>Dietary Guidelines for Americans</em> describes a healthy dietary pattern as one that</p>
<ul>
<li>Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils.
<ul>
<li>Whole grains and dark-green, leafy vegetables are good sources of magnesium. Low-fat milk and yogurt contain magnesium as well. Some ready-to-eat breakfast cereals are fortified with magnesium.</li>
</ul>
</li>
<li>Includes a variety of protein foods such as lean meats; poultry; eggs; seafood; beans, peas, and lentils; nuts and seeds; and soy products.
<ul>
<li>​​​​​​​Dried beans and legumes (such as soybeans, baked beans, lentils, and peanuts) and nuts (such as almonds and cashews) provide magnesium.</li>
</ul>
</li>
<li>Limits foods and beverages higher in added sugars, saturated fat, and sodium.</li>
<li>Limits alcoholic beverages.</li>
<li>Stays within your daily calorie needs.</li>
</ul>
<p>&nbsp;</p>
<section id="ctl00_ctl00_cphMain_cphPageContent_ctlfs_divCitations">
<h2 id="ref">References</h2>
<ol>
<li id="en1">Institute of Medicine (IOM). Food and Nutrition Board. <a href="http://www.nap.edu/openbook.php?record_id=5776" target="external" rel="noopener">Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>. Washington, DC: National Academy Press, 1997.</li>
<li id="en2">Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.</li>
<li id="en3">Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams &amp; Wilkins; 2012:159-75.</li>
<li id="en4">Volpe SL. Magnesium. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Ames, Iowa; John Wiley &amp; Sons, 2012:459-74.</li>
<li id="en5">Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res 2010;23:1-5. [<a href="https://pubmed.ncbi.nlm.nih.gov/20736141/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en6">Gibson, RS. Principles of Nutritional Assessment, 2nd ed. New York, NY: Oxford University Press, 2005.</li>
<li id="en7">Witkowski M, Hubert J, Mazur A. Methods of assessment of magnesium status in humans: a systematic review. Magnesium Res 2011;24:163-80. [<a href="https://pubmed.ncbi.nlm.nih.gov/22064327/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en8">Azoulay A, Garzon P, Eisenberg MJ. Comparison of the mineral content of tap water and bottled waters. J Gen Intern Med 2001;16:168-75. [<a href="https://pubmed.ncbi.nlm.nih.gov/11318912/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en9">Fine KD, Santa Ana CA, Porter JL, Fordtran JS. Intestinal absorption of magnesium from food and supplements. J Clin Invest 1991;88:396-402. [<a href="https://pubmed.ncbi.nlm.nih.gov/1864954/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en10">U.S. Department of Agriculture, Agricultural Research Service. <a href="https://fdc.nal.usda.gov/" target="external" rel="noopener">FoodData Central</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>, 2019.</li>
<li id="en11">U.S. Food and Drug Administration. <a href="https://www.federalregister.gov/documents/2016/05/27/2016-11867/food-labeling-revision-of-the-nutrition-and-supplement-facts-labels" target="external" rel="noopener">Food Labeling: Revision of the Nutrition and Supplement Facts Labels.</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a> 2016.</li>
<li id="en12">Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Ther 2001;8:345-57. [<a href="https://pubmed.ncbi.nlm.nih.gov/11550076/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en13">Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res 2001;14:257-62. [<a href="https://pubmed.ncbi.nlm.nih.gov/11794633/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en14">Mühlbauer B, Schwenk M, Coram WM, Antonin KH, Etienne P, Bieck PR, Douglas FL. Magnesium-L-aspartate-HCl and magnesium-oxide: bioavailability in healthy volunteers. Eur J Clin Pharmacol 1991;40:437-8. [<a href="https://pubmed.ncbi.nlm.nih.gov/2050185/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en15">Lindberg JS, Zobitz MM, Poindexter JR, Pak CY. Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Coll Nutr 1990;9:48-55. [<a href="https://pubmed.ncbi.nlm.nih.gov/2407766/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en16">Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other Mg preparations in a randomized, double-blind study. Mag Res 2003;16:183-91. [<a href="https://pubmed.ncbi.nlm.nih.gov/14596323/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en17">Spencer H, Norris C, Williams D. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 1994;13:479-84. [<a href="https://pubmed.ncbi.nlm.nih.gov/7836627/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en18">Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician 2009;80:157-62. [<a href="https://pubmed.ncbi.nlm.nih.gov/19621856/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en19">Phillips’®. <a href="https://www.livewell.bayer.com/sites/g/files/vrxlpx31351/files/2021-10/phillips-milk-of-magnesia-cherry.pdf" target="external" rel="noopener">Phillips’ Milk of Magnesia</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>. 2020.</li>
<li id="en20"><a href="http://www.rolaids.com/" target="external" rel="noopener">Rolaids®</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>. 2012.</li>
<li id="en21"><a href="http://www.tums.com/" target="external" rel="noopener">Tums®</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>. 2012.</li>
<li id="en22">U.S. Department of Agriculture, Agricultural Research Service. <a href="https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/usual/Usual_Intake_gender_WWEIA_2013_2016.pdf" target="external" rel="noopener">Usual Nutrient Intake from Food and Beverages, by Gender and Age, What We Eat in America, NHANES 2013-2016</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>; 2019.</li>
<li id="en23">Bailey RL, Fulgoni III VL, Keast DR, Dwyer JD. Dietary supplement use is associated with high intakes of minerals from food sources. Am J Clin Nutr 2011;94:1376-81. [<a href="https://pubmed.ncbi.nlm.nih.gov/21955646/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en24">Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev 2012;70:153-64. [<a href="https://pubmed.ncbi.nlm.nih.gov/22364157/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en25">Chaudhary DP, Sharma R, Bansal DD. Implications of magnesium deficiency in type 2 diabetes: a review. Biol Trace Elem Res 2010;134:119–29. [<a href="https://pubmed.ncbi.nlm.nih.gov/19629403/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en26">Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med 1996;156:1143-8. [<a href="https://pubmed.ncbi.nlm.nih.gov/8639008/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en27">Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review). J Am Coll Nutr 1994;13:416–23. [<a href="https://pubmed.ncbi.nlm.nih.gov/7836619/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en28">Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of U.S. adults. J Nutr 2003;133:2879-82. [<a href="https://pubmed.ncbi.nlm.nih.gov/12949381/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en29">Musso CG Magnesium metabolism in health and disease. Int Urol Nephrol 2009;41:357-62. [<a href="https://pubmed.ncbi.nlm.nih.gov/19274487/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en30">Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res 2009;22:235-46. [<a href="https://pubmed.ncbi.nlm.nih.gov/20228001/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en31">Dickinson HO, Nicolson D, Campbell F, Cook JV, Beyer FR, Ford GA, Mason J. Magnesium supplementation for the management of primary hypertension in adults. Cochrane Database of Systematic Reviews 2006: CD004640. [<a href="https://pubmed.ncbi.nlm.nih.gov/16856052/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en32">Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr 2012;66:411-8. [<a href="https://pubmed.ncbi.nlm.nih.gov/22318649/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en33">Champagne CM. Dietary interventions on blood pressure: the Dietary Approaches to Stop Hypertension (DASH) trials. Nutr Rev 2006;64:S53-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/16532899/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en34">U.S. Food and Drug Administration. <a href="https://www.fda.gov/media/155304/download" target="external" rel="noopener">RE: Petition for a qualified health claim for magnesium and reduced risk of high blood pressure (hypertension) (docket No. FDA-2016-Q-3770).</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a> January 10, 2022.</li>
<li id="en35">Peacock JM, Ohira T, Post W, Sotoodehnia N, Rosamond W, Folsom AR. Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J 2010;160:464-70. [<a href="https://pubmed.ncbi.nlm.nih.gov/20826254/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en36">Chiuve SE, Korngold EC, Januzzi Jr JL, Gantzer ML, Albert CM. Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr 2011;93:253-60. [<a href="https://pubmed.ncbi.nlm.nih.gov/21106914/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en37">Joosten MM, Gansevoort RT, Mukamal KJ, van der Harst P, Geleijnse JM, Feskens EJM, Navis G, Bakker SJL. Urinary and plasma magnesium and risk of ischemic heart disease. Am J Clin Nutr 2013;97:1299-306. [<a href="https://pubmed.ncbi.nlm.nih.gov/23485414/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en38">Del Gobbo LC, Imamura F, Wu JHY, Otto MCdO, Chiuve SE, Mozaffarian D. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2013;98:160-73. [<a href="https://pubmed.ncbi.nlm.nih.gov/23719551/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en39">Larsson SC, Orsini N, Wolk A. Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Am J Clin Nutr 2012;95:362-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/22205313/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en40">Song Y, Liu S. Magnesium for cardiovascular health: time for intervention. Am J Clin Nutr 2012;95:269-70. [<a href="https://pubmed.ncbi.nlm.nih.gov/22218155/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en41">Larsson SC, Wolk A. Magnesium intake and risk of type 2 diabetes: a meta-analysis. J Intern Med 2007;262:208-14. [<a href="https://pubmed.ncbi.nlm.nih.gov/17645588/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en42">Rodriguez-Moran M, Simental Mendia LE, Zambrano Galvan G, Guerrero-Romero F. The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnes Res 2011;24:156-62. [<a href="https://pubmed.ncbi.nlm.nih.gov/22198525/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en43">Simmons D, Joshi S, Shaw J. Hypomagnesaemia is associated with diabetes: not pre-diabetes, obesity or the metabolic syndrome. Diabetes Res Clin Pract 2010;87:261-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/20004036/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en44">Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H. Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007;167:956–65. [<a href="https://pubmed.ncbi.nlm.nih.gov/17502538/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en45">Dong J-Y, Xun P, He K, Qin L-Q. Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes Care 2011;34:2116-22. [<a href="https://pubmed.ncbi.nlm.nih.gov/21868780/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en46">Evert AB, Boucher JL, Cypress M, Dunbar SA, Franz MJ, Mayer-Davis EJ, Neumiller JJ, Nwankwo R, Verdi CL, Urbanski P, Yancy WS Jr. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 2013;36:3821-42. [<a href="https://pubmed.ncbi.nlm.nih.gov/24107659/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en47">Lima MDL, Cruz T, Pousada JC, Rodrigues LE, Barbosa K, Canguco V. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 1998;21:682-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/9589224/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en48">Rodriquez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003;26:1147-52. [<a href="https://pubmed.ncbi.nlm.nih.gov/12663588/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en49">de Valk HW, Verkaaik R, van Rijn HJ, Geerdink RA, Struyvenberg A. Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Diabet Med 1998;15:503-7 [<a href="https://pubmed.ncbi.nlm.nih.gov/9632126/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en50">Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr 2009;28:131–41. [<a href="https://pubmed.ncbi.nlm.nih.gov/19828898/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en51">Tucker KL. Osteoporosis prevention and nutrition. Curr Osteoporos Rep 2009;7:111-7. [<a href="https://pubmed.ncbi.nlm.nih.gov/19968914/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en52">Mutlu M, Argun M, Kilic E, Saraymen R, Yazar S. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal post-menopausal women. J Int Med Res 2007;35:692-5. [<a href="https://pubmed.ncbi.nlm.nih.gov/17944055/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en53">Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin S. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res 2010;133:136-43. [<a href="https://pubmed.ncbi.nlm.nih.gov/19488681/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en54">Sun-Edelstein C, Mauskop A. Role of magnesium in the pathogenesis and treatment of migraine. Expert Rev Neurother 2009;9:369–79 [<a href="https://pubmed.ncbi.nlm.nih.gov/19271946/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en55">Schürks M, Diener H-C, Goadsby P. Update on the prophylaxis of migraine. Cur Treat Options Neurol 2008;10:20–9. [<a href="https://pubmed.ncbi.nlm.nih.gov/18325296/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en56">Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults. Neurology 2012;78:1346-53. [<a href="https://pubmed.ncbi.nlm.nih.gov/22529203/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en57"><a href="http://naturaldatabase.therapeuticresearch.com/" target="external" rel="noopener">Natural Medicines Comprehensive Database</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"></a>. Magnesium. 2013.</li>
<li id="en58">Kutsal E, Aydemir C, Eldes N, Demirel F, Polat R, Taspnar O, Kulah E. Severe hypermagnesemia as a result of excessive cathartic ingestion in a child without renal failure. Pediatr Emerg Care 2007;23:570-2. [<a href="https://pubmed.ncbi.nlm.nih.gov/17726419/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en59">McGuire JK, Kulkarni MS, Baden HP. Fatal hypermagnesemia in a child treated with megavitamin/megamineral therapy. Pediatrics 2000;105:E18. [<a href="https://pubmed.ncbi.nlm.nih.gov/10654978/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en60">Onishi S, Yoshino S. Cathartic-induced fatal hypermagnesemia in the elderly. Intern Med 2006;45:207-10. [<a href="https://pubmed.ncbi.nlm.nih.gov/16543690/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en61">Dunn CJ, Goa KL. Risedronate: A review of its pharmacological properties and clinical use in resorptive bone disease. Drugs 2001;61:685-712. [<a href="https://pubmed.ncbi.nlm.nih.gov/11368289/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en62">Arayne MS, Sultana N, Hussain F. Interactions between ciprofloxacin and antacids&#8211;dissolution and adsorption studies. Drug Metabol Drug Interact 2005;21:117-29. [<a href="https://pubmed.ncbi.nlm.nih.gov/16355977/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en63">Sarafidis PA, Georgianos PI, Lasaridis AN. Diuretics in clinical practice. Part II: electrolyte and acid-base disorders complicating diuretic therapy. Expert Opin Drug Saf 2010;9:259-73. [<a href="https://pubmed.ncbi.nlm.nih.gov/20095916/" target="external" rel="noopener">PubMed abstract</a>]</li>
<li id="en64">U.S. Food and Drug Administration. <a href="https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-low-magnesium-levels-can-be-associated-long-term-use-proton-pump" target="external" rel="noopener">Proton Pump Inhibitor Drugs (PPIs): Drug Safety Communication—Low Magnesium Levels Can Be Associated With Long-Term Use.</a><a title="External Website" href="https://ods.od.nih.gov/About/exit_disclaimer.aspx"><img loading="lazy" decoding="async" class="externallink" src="https://ods.od.nih.gov/images/Common/externallink.png" alt="external link disclaimer" width="12" height="12" /></a> March 2, 2011.</li>
<li><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#:~:text=Magnesium%20is%20a%20cofactor%20in,%2C%20oxidative%20phosphorylation%2C%20and%20glycolysis." target="_blank" rel="noopener">sourced</a></li>
</ol>
</section>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>Why Walnuts Are A Good Snack To Eat Before Bed</title>
		<link>https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Sat, 20 Jan 2024 21:23:49 +0000</pubDate>
				<category><![CDATA[⚠️Breaking News⚠️]]></category>
		<category><![CDATA[❤️Heart Health⚕️]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Eating & Food Choices]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[🧠Brain Health🧠]]></category>
		<category><![CDATA[🧬Bio-Hacking 101]]></category>
		<category><![CDATA[Good Snack To Eat Before Bed]]></category>
		<category><![CDATA[Magnesium]]></category>
		<category><![CDATA[Walnuts]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=17042</guid>

					<description><![CDATA[Why Walnuts Are A Good Snack To Eat Before Bed It&#8217;s no secret that getting sufficient sleep is essential to maintaining good health. Sleeping is how the body recovers and repairs itself, so a lack of quality shut-eye can increase the risk of developing many health problems, including high blood pressure, heart disease, and depression, [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1>Why Walnuts Are A Good Snack To Eat Before Bed</h1>
<p>It&#8217;s no secret that getting sufficient sleep is essential to maintaining good health. Sleeping is how the body recovers and repairs itself, so a lack of quality shut-eye can increase the risk of developing many health problems, including high blood pressure, heart disease, and depression, according to Medical News Today. However, all too often, people struggle with inadequate or poor quality sleep, leaving them tired, fatigued, and unable to perform at their best. While there are a lot of reasons behind this, diet actually plays a starring role in the quality of our sleep.</p>
<p>It turns out that eating the right foods before bed can actually help us fall asleep easier, stay asleep longer, and wake up feeling more energized and refreshed. Meghan Dillon, a registered dietitian nutritionist and HelloFresh nutrition associate, recently explained to Mashed why walnuts are a particularly good food to snack on before hitting the hay. Walnuts&#8217; long list of nutrients can help encourage a good night&#8217;s rest while satisfying a craving for crunchiness.</p>
<h2>Walnuts contain lots of sleep-promoting magnesium<br />
<img loading="lazy" decoding="async" class="alignnone size-full wp-image-17047" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-contain-lots-of-sleep-promoting-magnesium-1647038331.webp" alt="" width="780" height="438" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-contain-lots-of-sleep-promoting-magnesium-1647038331.webp 780w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-contain-lots-of-sleep-promoting-magnesium-1647038331-400x225.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-contain-lots-of-sleep-promoting-magnesium-1647038331-768x431.webp 768w" sizes="(max-width: 780px) 100vw, 780px" /></h2>
<p>Walnuts contain a high amount of magnesium, a nutrient that has been shown to be beneficial for sleep. Dillon explained to Mashed that eating foods high in magnesium can help activate the parasympathetic nervous system, which Simply Psychology reports is also known as the &#8220;rest and digest&#8221; system. This system helps the body enter a relaxed state, slowing down our breathing, decreasing our heart rate, prompting digestion, and lowering activity in the eyes, blood vessels, and other areas. If the parasympathetic nervous system is not activated, &#8220;we may feel stressed and tense, causing us to experience difficulty falling asleep as our body fails to relax properly,&#8221; Dillon said.</p>
<p>Magnesium also helps send the brain signals that calm down the nervous system, according to Healthline. Additionally, magnesium may aid in the production of melatonin, the hormone that controls the body&#8217;s sleep-wake cycle. According to Dillon, &#8220;Magnesium deficiency is associated with low serum melatonin, whereas sufficient serum magnesium is associated with adequate serum melatonin.&#8221; Therefore, she recommends eating walnuts, as well as other magnesium-rich foods, like pumpkin seeds, peanuts, and cashews, to help promote healthy sleep.</p>
<h2>Walnuts are a good source of omega-3 fatty acids<br />
<img loading="lazy" decoding="async" class="alignnone size-full wp-image-17046" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-are-a-good-source-of-omega-3-fatty-acids-1647038331.webp" alt="" width="780" height="438" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-are-a-good-source-of-omega-3-fatty-acids-1647038331.webp 780w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-are-a-good-source-of-omega-3-fatty-acids-1647038331-400x225.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/walnuts-are-a-good-source-of-omega-3-fatty-acids-1647038331-768x431.webp 768w" sizes="(max-width: 780px) 100vw, 780px" /></h2>
<p>Dillon elaborated that walnuts are also a good choice for sleep because they contain high amounts of omega-3 fatty acids. These healthy fats have not only been shown to improve heart health and protect against certain cancers, but also to aid the body in sleeping better and longer (via The Sleep Doctor). This is because omega-3s have anti-inflammatory properties and can help decrease levels of a stress hormone called norepinephrine, which disrupts REM sleep. &#8220;The standard American diet contains a greater prevalence of pro-inflammatory foods,&#8221; Dillon said, adding that consuming foods rich in omega-3s can &#8220;balance the inflammation in our body, which may in turn improve our sleep quality.&#8221;</p>
<p>Omega-3 fatty acids, along with magnesium, can also help stimulate melatonin production, meaning walnuts pack a double-punch when it comes to this important sleep hormone. &#8220;One study found that low levels of the omega-3 fatty acid, DHA, are linked with lower levels of melatonin. Increasing the consumption of omega-3 fatty acids in those with low serum DHA may increase melatonin production, which is essential for restful sleep,&#8221; Dillon explained to Mashed.</p>
<h2>Some foods can disrupt sleep quality<br />
<img loading="lazy" decoding="async" class="alignnone size-full wp-image-17045" src="https://goodshepherdmedia.net/wp-content/uploads/2024/01/some-foods-can-disrupt-sleep-quality-1647038371.webp" alt="" width="780" height="438" srcset="https://goodshepherdmedia.net/wp-content/uploads/2024/01/some-foods-can-disrupt-sleep-quality-1647038371.webp 780w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/some-foods-can-disrupt-sleep-quality-1647038371-400x225.webp 400w, https://goodshepherdmedia.net/wp-content/uploads/2024/01/some-foods-can-disrupt-sleep-quality-1647038371-768x431.webp 768w" sizes="(max-width: 780px) 100vw, 780px" /></h2>
<p>Though walnuts are a great snack choice for those looking to improve their sleep, other nutritious foods can have the opposite effect. Dillon warns against pre-bedtime consumption of snacks that contain tyramine, an amino acid that is commonly found in pickled and fermented foods like sauerkraut. Although these items are full of beneficial probiotics, which aid in digestion, they also stimulate the sympathetic nervous system. While the parasympathetic nervous system is responsible for slowing the body down, the sympathetic nervous system revs up the body&#8217;s rapid involuntary response, or &#8220;fight or flight,&#8221; per Live Science. This speeds up the heart rate and makes the body feel alert and awake — not exactly a good recipe for drifting off to a restful sleep.</p>
<p>Of course, many of us already know that any food or beverages that contain caffeine can keep us awake at night. Dillon said that though caffeinated teas have helpful antioxidants, their caffeine content may cause us to &#8220;spend an extended amount of time in the &#8216;REM cycle&#8217; stage of sleep, too much of which can make us feel groggy the next day.&#8221; If you&#8217;re peckish before bed, put down the kombucha and caffeinated tea in favor of walnuts.<a href="https://www.mashed.com/796705/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">source</a></p>
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>How to Sleep Better: Your Guide for Good ZZZ</title>
		<link>https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Thu, 11 May 2023 10:20:01 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[How To]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[Guide for Good Sleep]]></category>
		<category><![CDATA[How to Sleep Better]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=13907</guid>

					<description><![CDATA[How to Sleep Better: Your Guide for Good ZZZ Some nights, no matter how comfortable your bed is, how busy your day was, or how much you know you need to be rested for tomorrow, a good night’s sleep still eludes you. Maybe you’re staring at the ceiling, unable to turn your mind off. Maybe [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 class="single-hero-title" style="text-align: center;">How to Sleep Better: Your Guide for Good ZZZ</h1>
<div class="intLeftCol left">
<nav id="section-navigation">
<div class="ptl_col_1">
<div class="ptl_portlet_vertical">
<div id="ctl00_ContentPlaceHolder1_ctl05_divView">
<div class="skip-nav">
<p>Some nights, no matter how comfortable your bed is, how busy your day was, or how much you know you need to be rested for tomorrow, a good night’s sleep still eludes you.</p>
<p>Maybe you’re staring at the ceiling, unable to turn your mind off. Maybe you’re tossing and turning all night or sweating while sleeping , never sinking into that deep REM sleep we all need. Or maybe you think you’re getting a good night of healthy sleep, but you wake up feeling so lethargic it’s like you never went to bed at all.</p>
<p>We’ve all been there—and fortunately, we can help. That’s why we’ve put together this guide of six tips for better sleep.</p>
</div>
</div>
</div>
</div>
</nav>
</div>
<div class="intRightCol right">
<div class="ptl_page">
<div class="ptl_col_1">
<div class="ptl_portlet_vertical">
<div id="ctl00_ContentPlaceHolder1_ctl10_divView">
<div id="divContent">
<div id="news_content_body">
<p><img loading="lazy" decoding="async" class="size-full wp-image-13900 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/GettyImages-860887064.jpg" alt="" width="800" height="609" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/GettyImages-860887064.jpg 800w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/GettyImages-860887064-400x305.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/GettyImages-860887064-768x585.jpg 768w" sizes="(max-width: 800px) 100vw, 800px" /></p>
<h2>1. Maintain a constant daily schedule</h2>
<p>Picking a set “bedtime” and wake-up time can help normalize your rest routine for your body. Be patient with yourself, as it will likely take some time to change your sleep schedule, but stick with it. It’s important to avoid hitting the snooze button, no matter how tempting. Even if it feels nice in the moment, that extra nap isn’t high quality and will likely just throw off your schedule and make you feel sluggish throughout the morning.</p>
<p>One solution for<strong> </strong>how to get better sleep is to maintain a consistent sleep schedule throughout the week. If you’re the kind of person who likes to stretch your sleep budget thin during the week, then catch up on the weekends, it’s probably bad news for your overall sleep quality.</p>
<p>However, your sleep quality can be greatly improved by keeping a consistent schedule.</p>
<p>Yes, this might mean going to bed a little earlier on weeknights and waking up a little earlier on weekends, but getting your body’s internal clock properly aligned in this way can have major long term benefits.</p>
<p>In fact, studies have shown that erratic sleep schedules can lead to a higher risk of:<sup>1</sup></p>
<ul>
<li>Obesity</li>
<li>Depression</li>
<li>Other disorders</li>
</ul>
<h3>How To Adjust Your Sleep Schedule</h3>
<p>Whether you’re starting a new job, readjusting after traveling to a different time zone, or just trying to break an unhealthy pattern, it can be a challenge to adjust your sleep schedule.</p>
<p>Fortunately, we have some tips for that, too:</p>
<ul>
<li><strong>Take it slow.</strong> Unlike turning back the clocks (a common cause of disrupted sleep), you don’t have to adjust your sleep schedule all at once. Tweak your bedtime and wake-up time by 15 minutes every day until they’re where you want them.</li>
<li><strong>Avoid naps.</strong> Look, everyone loves a good nap. But if you’re having trouble sleeping, dozing off during the day will only exacerbate the problem. Skip the siestas until your sleep schedule is squared away.</li>
<li><strong>Become a creature of darkness.</strong> We’re going to talk more about creating a relaxing bedtime environment below, but in short, your body doesn’t know it’s time to sleep if you keep shining light in your eyes.</li>
<li><strong>Then, open those curtains. </strong>When it comes to waking up, natural sunlight is what tells our body it’s time to get going. Whenever possible, get some sun on that skin as quickly as possible after your alarm goes off.</li>
</ul>
<p>Correct sleeping cartoon composition with human sleep statistics and image of sleeping woman with flat icons vector illustration</p>
<h2>2. Reduce caffeine intake</h2>
<p>Caffeine will take up to 12 hours to completely leave your system. This means that even if you are able to fall asleep at a decent hour with coffee in your system, the quality of your sleep may be severely reduced. Consider only drinking caffeinated beverages in the morning or switching to options with considerably lower amounts of caffeine, like decaf coffees or teas.</p>
<h2>3. Turn off the computer or television</h2>
<p>In addition to intellectual distractions that may get your thoughts and anxiety going, bright lights from your computer or television will stimulate your brain when it is trying to naturally wind down in the evening. We’d recommend avoiding all electronics at least an hour before you intend to head to bed.</p>
<p>Are you in bed right now searching for tips on how to get a good night’s  sleep? First of all, you’re busted! Second, you’re going to need to set aside your phone if you really want to sleep better.</p>
<p>Our sleep-wake cycle (also known as our circadian rhythm) is regulated by the production of the hormone melatonin. Studies have shown that the blue light emitted by cell phones restricts the production of melatonin.<sup>2</sup> This means that staring at your phone in bed can literally convince your brain that it isn’t nighttime at all.</p>
<p>(And we’re not even going to get into the agitation or anxiety that can come from scrolling work emails or social media right before trying to sleep.)</p>
<p>To improve your sleep quality, try to stop using screens at least 30 minutes before bed. You might also try these sleep expert activities to help your brain relax:</p>
<ul>
<li>Read a book (the paper kind)</li>
<li>Write in a journal or make a to-do list</li>
<li>Take a shower or bath</li>
<li>Meditate or listen to relaxing music</li>
</ul>
<h2>4. Don&#8217;t go to bed on a full stomach</h2>
<p>Related to the importance of your sleep schedule, it’s important that you try to eat dinner around the same time to keep your body on a regular overall schedule. If you’re really having cravings, stick to small snacks and avoid sugar, alcohol, and nicotine.</p>
<h2>Cut Out Midnight Snacks</h2>
<p>One activity that isn’t going to help you get better sleep is eating. Admittedly, we’ve all crept into the kitchen late at night to get something to munch on. But, if you’re having difficulty falling asleep, you may need to act like a gremlin, and stop eating after midnight (or well before).</p>
<p>Eating late and then lying down to go to sleep can cause heartburn or acid reflux, leaving you tossing and turning uncomfortably. Furthermore, if you’ve got a sweet tooth, your sugar high or caffeine intake might contribute to your insomnia.</p>
<p>Rather than having a late night snack, consider sipping on a cup of soothing, decaffeinated tea, such as chamomile or lavender tea. And if you do have to have a bedtime snack, consider these healthy late night snacks  that will curve your cravings and mitigate your sleep disruption.</p>
<h2>5. Don&#8217;t go to bed on an empty stomach</h2>
<p>At the same time, it doesn’t help to try and sleep when your stomach is growling. If your mind and body are distracted by how hungry you are, it is going to be much more difficult for you to put either at ease as you try to calm yourself for a restful night of sleep.</p>
<h2>6. Engage in regular exercise</h2>
<p>Exercise can actually help improve both the quality and quantity of sleep you get each nice. You will spend more time in deep sleep cycles if you’ve exercised during your day and will likely feel tired enough to fall asleep more easily. Squeezing in a workout can also help reduce anxiety and stress that normally disrupts your sleep practice.</p>
<h2>Exercise, But Not Too Late</h2>
<p>Studies have shown that staying active during the day and regularly exercising can lead to better sleep at night. But, there’s a cut-off point.</p>
<p>If you’re an evening exerciser, you’ll want to make sure that your workout is wrapped up at least an hour before you plan to sleep. Why?</p>
<p>Because exercising raises your heart rate and body temperature, it can be harder to get to quality sleep afterwards. You need a proper cool-down before getting into bed.</p>
<h2>7. Limit beverage consumption before bed</h2>
<p>Like we stated when it comes to eating before bed, it’s best to avoid drinking near your target bedtime. This will help reduce or eliminate any necessary trips to the bathroom that will disrupt your sleeping cycle.</p>
<h2>8. Keep your bedroom dark &amp; quiet</h2>
<p>Lights can naturally trick your body into thinking you should be awake, so it’s best to reduce outdoor light pollution and limit any indoor lighting in the evening as you prepare for sleep. Any efforts to reduce noise in your bedroom can also go a long way in improving the quality and quantity of your sleep.</p>
<h2>9. Invest in a comfortable mattress, pillow &amp; bedding</h2>
<p>Having the wrong tools can throw off your entire practice for any endeavor, especially when it comes to building a healthy sleep practice. An investment in your mattress, pillow, and bedding is an investment not only in your quality of sleep but your overall quality of health and life. If you have questions about what the best choices are for your specific needs, you can always <a href="https://www.federicidental.com/contact">reach out</a> to our sleep apnea dentists in Manahawkin.</p>
<h2>10. Go to sleep and wake up using your internal alarm clock.</h2>
<p>We mentioned the importance of avoiding the snooze button earlier, but the best possible practice is to actually avoid using an external alarm clock altogether.</p>
</div>
</div>
</div>
</div>
</div>
<h2></h2>
<h2><img loading="lazy" decoding="async" class="alignnone size-large wp-image-13898" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/5509e2d469beddfb5aca3571-766x1024.webp" alt="" width="640" height="856" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/5509e2d469beddfb5aca3571-766x1024.webp 766w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/5509e2d469beddfb5aca3571-299x400.webp 299w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/5509e2d469beddfb5aca3571-768x1027.webp 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/5509e2d469beddfb5aca3571.webp 1000w" sizes="(max-width: 640px) 100vw, 640px" /></h2>
<h2><img loading="lazy" decoding="async" class="size-large wp-image-13895 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/1_630_1120_1_70__News_20220414103728_The_all_day_guide_to_a_blissful_nights_sleep-1024x576.jpg" alt="" width="640" height="360" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/1_630_1120_1_70__News_20220414103728_The_all_day_guide_to_a_blissful_nights_sleep-1024x576.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/1_630_1120_1_70__News_20220414103728_The_all_day_guide_to_a_blissful_nights_sleep-400x225.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/1_630_1120_1_70__News_20220414103728_The_all_day_guide_to_a_blissful_nights_sleep-768x432.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/1_630_1120_1_70__News_20220414103728_The_all_day_guide_to_a_blissful_nights_sleep.jpg 1120w" sizes="(max-width: 640px) 100vw, 640px" /></h2>
<h2>Get Uninterrupted REM Sleep</h2>
<p>REM sleep is the deepest part of our sleepy time cycle. This deeps sleep begins around 90 minutes after we’ve fallen asleep. Getting a healthy amount of uninterrupted REM sleep has been shown to be critically important for a number of reasons:<sup>3</sup></p>
<ul>
<li>REM sleep improves cognitive function and memory</li>
<li>A lack of REM sleep can diminish your immune system</li>
<li>Missing out on REM sleep may cause you to be less alert the next day</li>
<li>Low levels of REM sleep can make pain hurt more</li>
</ul>
<p>However, if you’re a light sleeper, getting uninterrupted REM sleep can be easier said than done. To ensure nothing disturbs your slumber, you might try:</p>
<ul>
<li>Putting your cell phone on silent to avoid unnecessary notifications</li>
<li>Wearing an eye mask and/or ear plugs to block out light and sound</li>
<li>Upgrading to blackout curtains and/or trying out a white noise machine</li>
<li>Forcing your snoring partner to sleep on the couch (as a last resort, of course)</li>
</ul>
<div class="wp-block-image">
<figure class="aligncenter size-full"><img loading="lazy" decoding="async" class="wp-image-9828" src="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-1.jpg?auto=format" sizes="(max-width: 1000px) 100vw, 1000px" srcset="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-1.jpg?auto=format&amp;w=1000 1000w, https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-1.jpg?auto=format&amp;w=300 300w, https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-1.jpg?auto=format&amp;w=768 768w" alt="" width="556" height="370" data-cfsrc="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-1.jpg?auto=format" /></figure>
</div>
</div>
</div>
<p>&nbsp;</p>
<h2>How Much Sleep Should You Be Getting?</h2>
<p>Now that you know our tips on<strong> </strong>how to sleep better, how much sleep do you really need? Experts break down the recommended hours of sleep like this:<sup>4</sup></p>
<ul>
<li><strong>Teens (Ages 14 to 17)</strong> – 8 to 10 hours</li>
<li><strong>Young Adults and Adults (Ages 18 to 64)</strong> – 7 to 9 hours</li>
<li><strong>Older Adults (65+) </strong>– 7 to 8 hours</li>
</ul>
<p>(We skipped over children and younger age groups because they probably aren’t reading this. And, honestly, we’re a little jealous that experts recommend they sleep for ten hours per day.)</p>
<p>While these are the recommended ranges for each age group, there are also what’s known as “acceptable” amounts of sleep that expand the spread for each cohort. For instance, until age 25, it’s normal to need up to 11 hours of sleep. Whereas by the time you’ve hit 65, you may feel fully rested on only five hours of sleep per night.</p>
<p>Essentially, everyone’s a little different. While consulting a chart can be helpful, your own sleep needs are going to be unique to you.</p>
<div class="wp-block-image">
<figure class="aligncenter size-full"><img loading="lazy" decoding="async" class="wp-image-9827" src="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-2.jpg?auto=format" sizes="(max-width: 1000px) 100vw, 1000px" srcset="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-2.jpg?auto=format&amp;w=1000 1000w, https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-2.jpg?auto=format&amp;w=300 300w, https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-2.jpg?auto=format&amp;w=768 768w" alt="" width="520" height="346" data-cfsrc="https://casperblog.imgix.net/wp-content/uploads/2022/12/How-to-Sleep-Better-Your-Guide-for-Good-ZZZ-2.jpg?auto=format" /></figure>
</div>
<h3>How Do I Know If I’m Getting Enough Sleep?</h3>
<p>The hours of sleep you need depend a lot on how active you are and your overall health. To assess if you’re getting the optimal amount of sleep, consider the following questions:</p>
<ul>
<li>Do you feel grumpy and unproductive throughout your day?</li>
<li>Do you need to regularly consume coffee or other forms of caffeine to keep going?</li>
</ul>
<p>If you answered yes to either of these questions, then you’re probably skipping out on restful sleep.</p>
<p>A good way to test this—especially for those of you with a strict wake-up time—is to see how long you sleep on a day off when there’s no alarm to rouse you. That’s not just your body recovering from a tough week; it’s your body telling you how much deep sleep you naturally require.</p>
<p>You might also consider keeping a sleep journal or using a fitness tracker to log how many hours of restful sleep you’re getting. If you’re still struggling to suss out your snoozing statistics, you can consider participating in a sleep study.</p>
<p>&nbsp;</p>
<h2>Ask Yourself, <em>Is It You Or Your Bed?</em></h2>
<p>You’re sticking to a disciplined sleep schedule, cutting down on screen time, and are active everyday. And yet, when night comes, you’re still tossing and turning. Maybe the problem isn’t you at all.</p>
<p>Some signs you might need a new mattress include:</p>
<ul>
<li>Difficulty finding a comfortable position because of poking springs or sagging support</li>
<li>Feeling jostled or disturbed every time your partner moves around</li>
<li>Sneezing or itchy eyes caused by a build-up of allergens</li>
</ul>
<p>Your pillows and sheets can also have a significant impact on your sleep quality.</p>
<ul>
<li><strong>Feeling hot during the night?</strong> Consider switching to a more breathable sheet or investing in a cooling mattress, like the Wave Hybrid Snow Mattress which features advanced cooling technology that can prevent overheating for over 12 hours.</li>
<li><strong>Waking up with a stiff neck? </strong>You might need to find a pillow that better suits your sleeping position, like a Low Loft Pillow or a Body Pillow.</li>
</ul>
<blockquote>
<h3 style="text-align: center;"></h3>
</blockquote>
<hr />
<p>&nbsp;</p>
<h1>Your All-day Guide to a Perfect Night&#8217;s Sleep</h1>
<h4>Getting the rest you need isn’t just about bedtime – you’ve got to play the long game. Just make these easy zzz-friendly tweaks to your daily routines and you’ll be snoozing like a koala in no time.</h4>
<p>Many people think about sleep about twice a day: at night when they’re tired and need to go to<br />
bed, and in the morning when they’re still tired and want to stay there. But lack of shut-eye affects your whole day. Poor sleepers miss out on immune and emotional regulation as well as tissue restoration and repair, says sleep research psychologist Dr Jessica Payne. Stress may keep you awake, but insomnia can impair your ability to regulate tension the next day, creating a “sleep-stress snowball”, she says.</p>
<p>Stress also increases levels of neurotransmitters and hormones, such as cortisol and norepinephrine, keeping you in a hyper vigilant state, always watchful for tigers (or work enemies). “The more you’re stressed, the poorer your sleep is and the worse your stress is,” Dr Payne says.</p>
<p>Given sleep’s ability to wreak havoc on your waking hours, it only makes sense that your days might be causing you trouble at night. Think of your day like a fitness class, says sleep researcher and neurologist Dr Christopher Winter, author of <a href="https://www.booktopia.com.au/the-sleep-solution-chris-w-winter/book/9781925322033.html"><em>The Sleep Solution: Why Your Sleep Is Broken and </em><em>How to Fix It</em>.</a> Your decision-making brain is like a good instructor who leads you through the class, giving notice of what’s coming up next or how many burpees you’ll be doing. Without that sort of guidance, your body holds back, he says, trying to conserve energy to prepare for the unknown.</p>
<p>It boils down to this: A good night’s sleep relies on healthy daytime activities to regulate your internal clock, or circadian rhythm. “The interplay of sleep and rest, when it’s on a schedule, helps signal your <a href="https://www.preventionaus.com.au/article/how-to-build-your-brain-477350">brain</a> as to where it is within a 24-hour circadian cycle,” explains Dr Winter. Certain activities send the right signals and others can be harmful, adds neurologist Dr Donn Dexter.</p>
<p><strong>Here’s your 24-hour guide to which is which so you can snooze better, starting tonight. </strong></p>
<h2><span style="color: #0000ff;">MORNING</span></h2>
<h4>Quit hitting snooze</h4>
<p>Your greatest sleep mistakes happen in the morning, Dr Winter says. After a bad night, it’s tempting to give yourself a pity pass to sleep in or take a sick day. On the other hand, a regimented response at the start of the day helps set your brain’s sleep-wake clock. The exception: If you wake up too early, don’t try to force a return to sleep – it’s smarter to go ahead and get up. That reduces the chance of developing a chronic case of insomnia, according to a US study.</p>
<h4>Eat breakfast &#8211; even if you aren&#8217;t super hungry</h4>
<p>Banking kilojoules for dinner leads to overeating in the evening, and then a night of fitful sleep as you try to digest that heavy meal. In the morning, be sure to eat some <a href="https://www.preventionaus.com.au/gallery/8-creative-ways-to-use-protein-powder-482282">protein</a>, such as eggs, meat, yoghurt or milk. “Protein tends to facilitate the production of dopamine, a wakefulness neurotransmitter,” says Dr Winter. Bonus: dopamine allows you to feel pleasure and satisfaction.</p>
<h4>Step outside early</h4>
<p>Exposure to morning daylight, preferably combined with exercise, such as walking the dog or to the bus stop, supports regulation of your internal clock, as the sun suppresses melatonin. Even on a cloudy day, a 10- to 30-minute outdoor stroll provides more light than being indoors with all the lights on. If you can do a heart pumping workout, even better. That’ll increase the serotonin that enhances mood and wakefulness and informs your internal clock, Dr Winter says</p>
<h2><span style="color: #0000ff;">AFTERNOON</span></h2>
<h4>Find 10 mins of downtime</h4>
<p>Your temperature naturally drops in the early afternoon, aligned with circadian rhythms, causing sleepiness. A short catnap during your lunch break at the same time each day can reboot energy levels, but it isn’t necessary to fall asleep. “Resting isn’t a failed nap,” Dr Winter says. The goal is to practise relaxation techniques that’ll be useful later at night. Allow your mind to wander and get drowsy for about 10 minutes, then get back to what you were doing, refreshed. Tip: Reading a book in a warm, cosy spot will make your eyes nice and heavy.</p>
<h4>Don&#8217;t chug coffee</h4>
<p>Your body produces adenosine, a molecule that serves as the ‘energy currency’ for the body and also promotes sleepiness, says Dr Mathew. As a stimulant, <a href="https://www.preventionaus.com.au/article/how-much-caffeine-is-too-much-478313">caffeine</a> blocks adenosine and inhibits your brain’s natural increase in sleepiness as you move toward nighttime. Herbal tea or water is better in the afternoon. Plus, if you drink water throughout the day, you’ll need less in the evening, helping you to avoid those 3am bathroom trips.</p>
<h4>Work out in the daytime</h4>
<p>Exercising raises body temperature and levels of epinephrine and adrenaline, known sleep fighters. So, work out only during daylight hours to give time for heat and hormones to quiet down. “A falling body temperature almost acts like a signal that brings on sleep,” Dr Mathew says.</p>
<h4>Do a short meditation</h4>
<p>Decreasing daytime anxiety and worry can help you doze more deeply at night. Find five to 10 minutes to use the ‘body scan’ meditation technique, observing your body’s sensations, moving slowly from toes to scalp (or the reverse). Melt away stress either on your own or using a<br />
guided meditation in an app or on YouTube.</p>
<h2><span style="color: #0000ff;">EVENING</span></h2>
<h4>Write down what&#8217;s bugging you</h4>
<p>Dr Payne says that when you don’t offload the day’s events, your brain continues to process stressful situations throughout the night. So, by writing down any problems beforehand, you can improve compartmentalisation and save figuring out the solutions for the morning. If you’re lying in bed stressing about sleep itself, get up and do something quiet for 15 minutes, such as reading or sketching in a low-lit room &#8211; steer clear of bright screens. “Some people treat the bed like a bus stop,” Dr Winter says, and obsess over missing the sleep bus. Adjust your expectations and start again tomorrow.</p>
<h4>Create a ritual</h4>
<p>Any kind of stimulus is problematic – even mindless Netflix reruns. You’ll experience subtle increases in blood pressure, heart rate and sweating. Instead, take at least 20 minutes to dial it down. Try gentle stretching, <a href="https://www.preventionaus.com.au/article/how-to-meditate-a-simple-guide-to-10-minute-meditation-552165">meditating</a> or taking a bath. Think of it as a ‘bookmark’ at day’s end, Dr Payne says, telling the body and brain it’s okay to sleep.</p>
<h4>Turn off the ceiling lights</h4>
<p>Exposure to bright blue light can reduce melatonin levels by up to 50 per cent, says Dr Satchin Panda, author of The Circadian Code. And it’s not just your phone that’s to blame. Cool-hued ceiling lights also produce blue light. So, after dinner, switch to table lamps and fl oor lamps with warm- or orange-hued light bulbs. Electronic devices should also be set to night mode to warm the screen colour.</p>
<h4>Stop eating at least two hours before bed</h4>
<p>And also keep dinner on the lighter side. Your body’s digestive and waste functions need rest and downtime and to learn when “the kitchen is closed”, Dr Panda says, to prevent midnight snacking.</p>
<h2>Are you getting enough sleep?</h2>
<p>There’s a difference between time in bed and optimal shut-eye. The ideal sleep amount is between seven and eight hours, but to pull that off, you need to slide between the sheets at least eight hours before the alarm sounds. That way, you’ll have unhurried time to fall asleep and accommodate unplanned night waking. It’s normal to wake up during the night or toss and<br />
turn a bit, but taking more than 30 minutes to fall back asleep is known as ‘sleep maintenance<br />
insomnia’. If you’re having issues with night waking, try avoiding naps altogether during the day, suggests sleep expert Dr Reeba Mathew.</p>
<h2>Could it be serious?</h2>
<p>When patients visit Dr Mathew with sleep-related problems, she first rules out an undiagnosed sleep disorder, such as sleep apnoea, sleep-related low oxygen or restless legs syndrome.<br />
Patients with untreated apnoea, for example, have an increased risk of blood pressure-related and cardiac problems, including heart failure, she says. A vicious cycle between untreated apnoea and early <a href="https://www.preventionaus.com.au/article/5-hidden-heart-attack-triggers-497704">heart disease</a> can ensue and, in severe cases, lead to risk of heart attack. Seek your doctor’s advice if you have been snoring, get plenty of sleep but still feel fatigued, or are otherwise concerned.</p>
<h3 style="text-align: center;"></h3>
<p><img loading="lazy" decoding="async" class="wp-image-13899 aligncenter" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/sleep-better-infographic-composition-vector-20430224-e1683713628884.jpg" alt="" width="667" height="544" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/sleep-better-infographic-composition-vector-20430224-e1683713628884.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/sleep-better-infographic-composition-vector-20430224-e1683713628884-400x326.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/sleep-better-infographic-composition-vector-20430224-e1683713628884-768x626.jpg 768w" sizes="(max-width: 667px) 100vw, 667px" /></p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p><img loading="lazy" decoding="async" class="size-full wp-image-13909 aligncenter" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-scaled.jpg" alt="" width="680" height="2560" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-scaled.jpg 680w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-106x400.jpg 106w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-272x1024.jpg 272w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-408x1536.jpg 408w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/how-to-sleep-better-infographic-768x2892-1-544x2048.jpg 544w" sizes="(max-width: 680px) 100vw, 680px" /></p>
<div class="is-layout-constrained wp-block-group">
<div class="wp-block-group__inner-container">
<p><strong>Sources: </strong></p>
<ol>
<li>Everyday Health. <em>How to Fix Your Sleep Schedule. </em><a href="https://www.everydayhealth.com/sleep/insomnia/resetting-your-clock.aspx" target="_blank" rel="noreferrer noopener nofollow">https://www.everydayhealth.com/sleep/insomnia/resetting-your-clock.aspx</a></li>
<li>British Journal of Ophthalmology. <em>Blocking the Blue. </em><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857207/" target="_blank" rel="noreferrer noopener nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857207/</a></li>
<li>The National Sleep Foundation. <em>What Is REM Sleep?</em> <a href="https://www.thensf.org/what-is-rem-sleep/" target="_blank" rel="noreferrer noopener nofollow">https://www.thensf.org/what-is-rem-sleep/</a></li>
<li>Sleep Foundation. <em>How Much Sleep Do We Really Need?  </em><a href="https://www.sleepfoundation.org/how-sleep-works/how-much-sleep-do-we-really-need" target="_blank" rel="noreferrer noopener nofollow">https://www.sleepfoundation.org/how-sleep-works/how-much-sleep-do-we-really-need</a></li>
<li><a href="https://casper.com/blog/how-to-get-a-good-night-sleep/" target="_blank" rel="noopener">source</a></li>
<li><a href="https://www.federicidental.com/our-blog/10-tips-for-better-sleep" target="_blank" rel="noopener">source</a></li>
<li><a href="https://www.preventionaus.com.au/article/your-all-day-guide-to-a-perfect-nights-sleep-578722" target="_blank" rel="noopener">source</a></li>
</ol>
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
</div>
</div>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>The Right Noise &#8211; Pink, White, Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</title>
		<link>https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Wed, 10 May 2023 10:03:30 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[How To]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Women's Health]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[Black Noise]]></category>
		<category><![CDATA[Brown Noise]]></category>
		<category><![CDATA[Pink Noise]]></category>
		<category><![CDATA[Red Noise]]></category>
		<category><![CDATA[The Right Noise]]></category>
		<category><![CDATA[White Noise]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=13894</guid>

					<description><![CDATA[The Right Noise &#8211; Pink, White, Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep You may find yourself tossing and turning every night, wondering if there’s ever going to be a way for you to get a good night’s sleep. The solution may be as simple as “colorful” noises. Before you [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1>The Right Noise &#8211; Pink, White, Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</h1>
<p>You may find yourself tossing and turning every night, wondering if there’s ever going to be a way for you to get a <a href="https://casper.com/blog/how-much-sleep-do-i-need/">good night’s sleep</a>. The solution may be as simple as “colorful” noises.</p>
<p>Before you buy that sound machine or download that white noise app, here’s a look at the different sounds and how they help you get a <a href="https://casper.com/blog/how-to-get-a-good-night-sleep/" target="_blank" rel="noreferrer noopener">good night’s sleep</a>.</p>
<p>Pink noise and white noise use the variation of high and low frequencies, which is associated with a peaceful rest throughout the night. But you may wonder:  Pink noise vs. white noise, what’s the difference?</p>
<p>Below we explain what pink noise and white noise are and how they are different. We also discuss other types of background noise people commonly use for sleep.</p>
<h2 id="091e9c5e81fe9bc1-2-6" class="jumplink-headers">Can White, Pink, and Brown Noise Help You Sleep?</h2>
<p>For some people, the grainy static sound you hear in white noise can improve sleep. It helps by masking the background noise and tuning it out. One recent study found that 38% of people fell asleep faster listening to white noise.</p>
<p>Pink noise reduces the difference between the background hum and loud, jarring noises that jolt you out of sleep, like a door slamming, a car horn honking, or someone snoring. So it may help you fall asleep faster and keep you in a deep sleep longer. You may also feel more rested when you wake up.</p>
<p>There isn’t much research yet on exactly how pink noise works and how well it helps you sleep. One study found that it lowered brain activity and led to more stable sleep. Another study found people who used it slept more deeply.</p>
<p>Studies are limited, but pink noise may also boost your memory. A recent study found that older adults who used it at night did better on memory tests the next day.</p>
<p>We need more research to find out how pink noise affects your sleep, focus, and memory. But it’s safe and has no downside, so you may want to try it to see if it helps you.</p>
<section>As for brown noise, there aren’t a lot of studies to support its effect on sleep.But does listening to sound all night for good sleep really work? When you’re asleep, your brain is hard at work repairing and restoring your body. Would the constant hum in the background let your brain do its job? Experts don’t know the full answer.But if it helps you, carry on. Just make sure you don’t keep the volume too loud. According to the CDC, listening to sounds over 70 decibels over a long period of time can damage your hearing.</section>
<section></section>
<section>
<section> </section>
</section>
<p><img loading="lazy" decoding="async" class="alignnone wp-image-13901" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/whitepinkbrownnoise.jpg" alt="" width="733" height="497" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/whitepinkbrownnoise.jpg 432w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/whitepinkbrownnoise-400x271.jpg 400w" sizes="(max-width: 733px) 100vw, 733px" /></p>
<p>&nbsp;</p>
<blockquote>
<h1 style="text-align: center;"><strong><span style="color: #ff00ff;">Pink</span>, <span style="color: #993300;">Brown</span>, </strong><strong>White, </strong><strong>and <span style="color: #0000ff;">Blue</span> <span style="color: #ff0000;">Noise</span>: <span style="color: #339966;">Definitions and Examples</span></strong></h1>
</blockquote>
<p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-13902" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/Multiscale-entropy-of-white-noise-in-black-color-blue-noise-in-blue-color-pink-noise-in.png" alt="" width="850" height="478" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/Multiscale-entropy-of-white-noise-in-black-color-blue-noise-in-blue-color-pink-noise-in.png 850w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/Multiscale-entropy-of-white-noise-in-black-color-blue-noise-in-blue-color-pink-noise-in-400x225.png 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/Multiscale-entropy-of-white-noise-in-black-color-blue-noise-in-blue-color-pink-noise-in-768x432.png 768w" sizes="(max-width: 850px) 100vw, 850px" /></p>
<p>Trying to decide which color noise is right for you can be tricky at first. It may take some time to realize which sound works best for you, whether it’s rustling leaves, thunder, or whirring fans.</p>
<p>With some knowledge and a little time, however, you’ll quickly find the best option for your sleep habits. Here’s what you need to know about pink noise vs. white noise and how they compare to other sonic hues used for sleeping.</p>
<h1><span style="color: #ff00ff;"><strong>What is Pink Noise?</strong></span></h1>
<h3><strong>Pink Noise is Used to Reduce Brain Waves</strong></h3>
<p>In <a href="https://www.ncbi.nlm.nih.gov/pubmed/22726808" rel="nofollow">this study</a>, researchers found that those who listened to steady pink waves saw an increase in stable sleep. This is because pink noise may have the ability to reduce brain waves, which allows you to fall asleep faster. This color noise is a preferred method by many because it is deeper than white noise, but not as deep as brown.</p>
<p>Pink noise is a constant sound in the background. It filters out things that distract you, like people talking or cars going by, so they don’t interrupt your sleep. You may hear it called ambient noise.</p>
<p>Like white noise, it’s a steady background hum that may give you a better night’s sleep. But it uses deeper sounds and lower sound waves, so it may be gentler and more soothing. Basically, pink has a lower pitch than white noise.</p>
<p>Pink noise uses a consistent frequency, or pitch, to create a more even, flat sound, like a steady rain, wind rustling through trees, or waves on a beach. Its added depth and lower waves filter out higher sounds. As a result, you hear more relaxing, lower-frequency sounds.</p>
<p><iframe title="Pink Noise Ten Hours - The Classic Now in Dark Screen" width="640" height="360" src="https://www.youtube.com/embed/8SHf6wmX5MU?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<p><img loading="lazy" decoding="async" class="size-large wp-image-13903 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise-1024x482.jpg" alt="" width="640" height="301" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise-1024x482.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise-400x188.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise-768x362.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise-1536x723.jpg 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-pink-noise.jpg 2048w" sizes="(max-width: 640px) 100vw, 640px" /></p>
<p>With pink noise, lower frequencies are louder while higher frequencies are more diminished. This creates a soothing sound and is a great option for those who find white noise annoying and disruptive. Pink noise leans more toward environmental noise, so it’s no surprise most people prefer it.</p>
<p>In <a href="https://www.frontiersin.org/articles/10.3389/fnhum.2017.00109/full" rel="nofollow">this study</a>, a link was found between pink noise and deep sleep. This may be because pink noise is especially relaxing when used to drown out unwanted sounds and outside noises that could interfere with a person’s sleep.</p>
<p><strong>Examples of Pink Noise:</strong></p>
<ul>
<li>Rustling leaves</li>
<li>Steady rain</li>
<li>Ocean waves</li>
<li>Heartbeats</li>
</ul>
<h1></h1>
<h3><strong>Pink + Brown Noise Helps Tinnitus</strong></h3>
<p>According to <a href="https://www.popsci.com/science/article/2010-01/tinnitus-sufferers-find-healing-power-their-favorite-songs/" rel="nofollow">Popular Science</a>,<strong> </strong>those who suffer from tinnitus (constant ringing in ears) prefer pink or brown noise due to the lower frequencies. White noise can be aggravating to those with sensitive hearing because the high frequency sounds are more intense, making it harder for the person to fall asleep.</p>
<p>&nbsp;</p>
<h1><span style="color: #993300;"><strong>What is Brown Noise?</strong></span></h1>
<h3><strong>Brown Noise Promotes Concentration</strong></h3>
<p>Brown noise may help with getting a good night’s sleep, but it can also help with focus and concentration. Many people prefer listening to brown noise when studying or working to improve productivity and drown out any distractions. It can also help <a href="https://casper.com/blog/sleep-anxiety-guide/">ease anxiety</a>, especially in high-stress situations.</p>
<p>Brown noise, also called red noise, produces a rumbling sound that’s deeper with a bass-like tone than pink or white noise. The sound level (decibels) decreases as the frequency goes up more than it does in pink noise. It’s similar to a steady heavy rainfall or a shower with good pressure. Some sleep apps use this sound instead of pink noise to give it a deeper, grainier effect.</p>
<p>Studies show that brown noise might help lower symptoms if you have ringing in your ears. It’s also shown to improve your thinking skills. More research is needed to see if and how brown noise affects sleep.</p>
<p><iframe title="Smoothed Brown Noise 8-Hours - Remastered, for Relaxation, Sleep, Studying and Tinnitus &#x262f;108" width="640" height="360" src="https://www.youtube.com/embed/RqzGzwTY-6w?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<p><img loading="lazy" decoding="async" class="size-large wp-image-13904 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise-1024x482.jpg" alt="" width="640" height="301" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise-1024x482.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise-400x188.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise-768x362.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise-1536x723.jpg 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-brown-noise.jpg 2048w" sizes="(max-width: 640px) 100vw, 640px" /></p>
<p>Brown noise is deeper and stronger at the low end of the sound spectrum. Unlike pink and white noise, it doesn’t contain any high-frequency sounds. Though not a common option for sound sleep, brown noise can help certain people with concentration. According to the CEO of <a href="https://asticorp.com/" rel="nofollow">Adaptive Sound Technologies, Inc</a>, Sam Nicolino, brown noise “has more bass than white noise, making it more pleasant to listen to.”</p>
<p><strong>Examples of Brown Noise:</strong></p>
<ul>
<li>Low roaring</li>
<li>Strong waterfalls</li>
<li>Thunder</li>
</ul>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<h1><strong>What is White Noise?</strong></h1>
<h3><strong> White Noise Benefits Include Masking Sounds </strong></h3>
<p>Many people find success in sleeping when listening to white noise because it drowns out unwanted sounds. Smaller environmental sounds around you can distract you from getting a good night’s rest. However, when using a white noise machine, any noises that happen are drowned out by the noise you’re already hearing.</p>
<p><iframe title="White Noise Black Screen | Sleep, Study, Focus | 10 Hours" width="640" height="360" src="https://www.youtube.com/embed/nMfPqeZjc2c?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<p><img loading="lazy" decoding="async" class="size-large wp-image-13905 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise-1024x482.jpg" alt="" width="640" height="301" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise-1024x482.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise-400x188.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise-768x362.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise-1536x723.jpg 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/what-is-white-noise.jpg 2048w" sizes="(max-width: 640px) 100vw, 640px" /></p>
<p>White noise is equally spread across the sound spectrum, representing all audible frequencies at the same intensity. Because of that, many people find it hard to listen to when falling asleep because they get startled hearing high-pitched noises or heavy bass sounds.  So, how does white noise help you sleep? According to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923834/" target="_blank" rel="noreferrer noopener">this study</a>, others find these frequencies relaxing because they block out distracting and unwanted sounds.</p>
<p>You can imagine white noise as similar to white light. When every color on the spectrum is bright, it becomes white light — similarly, white noise includes all frequencies at the same intensity.</p>
<p><strong>Examples of White Noise:</strong></p>
<ul>
<li>Whirring fan</li>
<li>Radio or television static</li>
<li>Vacuum</li>
<li>Humming air conditioner</li>
</ul>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<h1><span style="color: #ff0000;"><strong>What Are the Other Colors of Noise?</strong></span></h1>
<h3><span style="color: #000000;"><strong>Black noise</strong></span><span style="color: #ff0000;"><strong>: </strong>This type of noise uses pure silence with sudden occurrences of noise. The dominant energy level is zero throughout all frequencies with bits of random noise and occasional rises.<span style="color: #000000;"> In Black noise, there is complete silence with bits of random noise. Some people need this type of silence to get quality sleep.</span></span></h3>
<p><iframe title="Black Noise Black Screen 12 hours. Black Noise for Studying, Sleeping and Relaxation. Sweet Noise" width="640" height="360" src="https://www.youtube.com/embed/KxvhW7qLtjg?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<h3><span style="color: #ff0000;"><strong>Red noise:</strong> This is another name for brown noise. The two mean the same exact thing: deep sounds at the low end of the spectrum with minimal high-frequency sounds.</span></h3>
<p>Red noise is another name for brown noise. The two mean the same: deep sounds at the low end of the spectrum with minimal high-frequency sounds.</p>
<p>Brown noise is much deeper than pink and white noise and has higher energy at a lower frequency. As a result, it induces sleep and relaxation.</p>
<p><iframe title="Super Deep Red Noise (12 Hours)" width="640" height="360" src="https://www.youtube.com/embed/u3sWyjDFC5Y?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<h3><span style="color: #0000ff;">Blue Noise<span style="color: #ff0000;"><strong>:</strong> Blue noise contains all the audible frequencies, but the higher-pitched frequencies are amplified. Because of this, blue noise can sound harsh to some people and isn’t widely used for sleep support. An example of this type of noise would be a hissing hose. <span style="color: #0000ff;">Blue noise can sound irritating to many people as its frequencies are higher-pitched. Thus, it can&#8217;t support quality sleep. Its power increases as the frequency goes up. Blue noise sounds slightly shriller than pink and white noise. Imagine the hissing noise you hear when a water spray is turned on.</span></span></span></h3>
<p><iframe title="Blue Noise Ambient High Frequency Sound for Ten Hours" width="640" height="360" src="https://www.youtube.com/embed/WSCU_t3o7KI?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<p><strong>Violet noise. </strong>Also called purple noise, it’s the opposite of brown noise. The volume goes up when the frequency does and it gains power faster than blue noise. It’s one of the higher-pitched color noises. It’s often used to treat <a href="https://www.webmd.com/a-to-z-guides/understanding-tinnitus-basics" data-crosslink-type="article" data-metrics-link="">tinnitus</a>, a condition that causes loud ringing in one or both ears.</p>
<p><iframe title="Ten Hours of Violet Noise  - Ambient Sound - High Frequency" width="640" height="360" src="https://www.youtube.com/embed/GYZy5f92FpQ?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<p><strong>Grey noise. </strong>This produces noise at higher and lower frequencies but not so much in the middle frequencies. It’s similar to white noise, but more balanced.</p>
<p><iframe title="Grey Noise Ambient Sound for Ten Hours" width="640" height="360" src="https://www.youtube.com/embed/0iGdLDeyeso?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<hr />
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
<p>&nbsp;</p>
<h1><strong>Tips to Bolster the Effects of Color Noise</strong></h1>
<p>Though utilizing color noises in your bedtime routine can help you get a good night’s sleep, there’s still a variety of factors you should consider before hitting the hay to ensure your body and mind are in a relaxed state.</p>
<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-13906" src="https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise-1024x747.jpg" alt="" width="640" height="467" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise-1024x747.jpg 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise-400x292.jpg 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise-768x560.jpg 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise-1536x1121.jpg 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/05/tips-to-bolster-the-effects-of-color-noise.jpg 2048w" sizes="(max-width: 640px) 100vw, 640px" /></figure>
<p>Check out our tips below:</p>
<h3><strong>1. Turn Off Bright Lights</strong></h3>
<p>Scrolling through your smartphone or watching TV before bedtime suppresses melatonin, making it hard for you to go to sleep. Avoid bright lights from screens or lamps at least an hour before you go to bed. If you’re looking for a soothing night light option, a <a href="https://casper.com/glow-light/">glow light</a> can give your bedroom a soft glow that dims as you fall asleep.</p>
<h3><strong>2. Exercise Regularly</strong></h3>
<p>Implementing a consistent exercise routine during the day may help promote a better night’s sleep. Since exercising exerts physical and mental energy, you’ll notice yourself feeling more tired at night.</p>
<h3><strong>3. Establish a Sleep Schedule</strong></h3>
<p>Making sure you wake up and go to bed at the same time every day is important, otherwise you’ll find yourself feeling <a href="https://casper.com/blog/sleep-deprivation-stages/">sleep deprived</a>. Set an alarm every morning and go to bed at the same time every night — it’ll make a big difference in your sleep quality. Check out our <a href="https://casper.com/blog/sleep-calculator/">sleep calculator</a> to figure out how much sleep you need.</p>
<h3><strong>4. Limit Food Intake Before Bed</strong></h3>
<p>Eating large meals before sleep can inhibit sleep quality and cause the body’s metabolism to slow down. <a href="https://www.mdpi.com/2072-6643/7/4/2648" rel="nofollow">Research</a> shows, however, that eating small, nutritious snacks like fruit or toast before bed can actually be beneficial and combats hunger with little negative effect.</p>
<h3><strong>5. Avoid Stimulants At Night</strong></h3>
<p>Avoid drinking caffeine before bedtime. Doing so may result in restless nights and lack of sleep, so be sure to limit your caffeine intake to morning or midday. If you find yourself experiencing a <a href="https://casper.com/blog/why-does-coffee-make-me-sleepy/">caffeine crash</a> during the day, it’s best to avoid drinking it entirely. Alcohol also reduces your quality of sleep by disrupting your circadian rhythm.</p>
<h3><strong>6. Limit Naps </strong></h3>
<p>Napping during the day can disrupt your sleep schedule and make it harder for you to get some shut eye. According to the <a href="https://www.sleep.org/how-long-to-nap/" rel="nofollow">National Sleep Foundation</a>, napping for 20 minutes or less is the most effective way to feel refreshed and still be able to go to bed.</p>
<p>Still unable to get some much-needed rest? You might want to invest in higher quality <a href="https://casper.com/bedding/sheets/">sheets</a> and <a href="https://casper.com/pillows/">pillows</a>, or maybe even a <a href="https://casper.com/glow-light/">glow light</a>. With the right bedding and color noise, you’ll be nodding off in no time. <a href="https://casper.com/blog/pink-noise-vs-white-noise/" target="_blank" rel="noopener">source</a></p>
<p>&nbsp;</p>
<h2 id="Other_Habits_that_would_help_you_sleep_better" class="gwm_blog_content_title">Other Habits that would help you sleep better</h2>
<div class="gwm_blog_content_content">
<p>Besides using noise colors to aid better sleep, good sleep habits are also essential.</p>
</div>
<section>
<h2 id="091e9c5e81fe9bc1-3-9" class="jumplink-headers">Where to Get White, Pink, and Brown Noise</h2>
<p>You have many options for adding a color noise to your sleep routine. For example, you can:</p>
<ul>
<li>Get a noise app from your smartphone’s app store or on YouTube, then play it as you go to sleep at night.</li>
<li>Find a clip of your choice of color noise online. Download a looping track from organizations like the American Tinnitus Association or the Misophonia Institute.</li>
<li>Get a sound machine or noise generator that specifically gives you a choice between white, pink, or brown noise.</li>
</ul>
</section>
<section>
<h2 id="091e9c5e81fe9bc1-3-10" class="jumplink-headers">Tips for Using Noise Safely</h2>
<p>Try different sounds, tracks, and volumes to see what works best for you.</p>
<section>If the sound of the wind doesn’t soothe you, try a babbling brook. If a sound machine with pink noise doesn’t help you sleep better, try a few different smartphone apps until you find one that works. Raise the volume or lower it until you find your sweet spot.If you want to use headphones but they don’t feel good, try earbuds. You can also find special headphones for sleeping. They use a soft headband to keep them in place.</section>
<section>
<h2 id="091e9c5e81fe9bc1-3-11" class="jumplink-headers">How to Get the Most Out of Color Noise</h2>
<p>Pink noise may help you nod off faster and enjoy a longer, deeper sleep. But it won’t work well if you have poor sleep habits.</p>
<p>To get the most out of pink noise, make these habits part of your nightly routine:</p>
<ul>
<li><strong>Sleep Routine: Get on a schedule.</strong> Go to bed at the same time every night and wake up at the same time in the morning, even on weekends.</li>
<li><strong> </strong>Make sure to sleep at a specific time every day. Also, cut down on tea/caffeine as it hampers the sleep cycle.</li>
<li><strong>Exercise:  Work out during the day.</strong> Daytime exercise helps you fall asleep faster at night. Being physically active during the day will help to sleep instantly at night. Exercising will relax the muscles that will aid in peaceful sleep.</li>
<li><strong>Go dark.</strong> Create a sleep-friendly bedroom that’s quiet, dark, and at a comfortable temperature.</li>
<li><strong>Avoid sleep interrupters.</strong> Limit caffeine, alcohol, and big meals before you go to bed.</li>
<li><strong>Mindful Eating </strong>Have a light dinner before sleeping. Be mindful while eating as a heavy stomach can disrupt peaceful sleep.</li>
<li><strong>Relaxing Activities </strong>Before sleeping, try some relaxing activities such as meditating, reading, and stretching exercises.</li>
<li><strong>Peaceful Atmosphere </strong>While sleeping, create a calm atmosphere by refreshing light colors. Also, avoid screen light from smartphones and TV.</li>
</ul>
</section>
</section>
<p><a href="https://www.webmd.com/sleep-disorders/pink-noise-sleep" target="_blank" rel="noopener">source</a></p>
<p>&nbsp;</p>
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>How to Reset Your Sleep Cycle When You Live With Insomnia</title>
		<link>https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Sun, 15 Jan 2023 18:48:38 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Healthy Thoughts]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[Circadian Rhythm]]></category>
		<category><![CDATA[Insomnia]]></category>
		<category><![CDATA[Reset Your Sleep Cycle]]></category>
		<category><![CDATA[sleep cycle]]></category>
		<category><![CDATA[Sleep Health]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=8356</guid>

					<description><![CDATA[How to Reset Your Sleep Cycle When You Live With Insomnia If you have chronic insomnia, you’ve likely been working with your doctor or a sleep specialist on ways to get more quality sleep. But sometimes, life can thwart the best-laid sleep plans. Travel, a newborn baby, shift work, and other disruptions can get in the way of your insomnia-busting [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;">How to Reset Your Sleep Cycle When You Live With Insomnia</h1>
<p><iframe title="Can You Reset Your Circadian Rhythm?" width="640" height="360" src="https://www.youtube.com/embed/A198Tdrknsc?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
<section>If you have chronic <a href="https://www.webmd.com/sleep-disorders/insomnia-symptoms-and-causes" data-crosslink-type="article" data-metrics-link="">insomnia</a>, you’ve likely been working with your doctor or a sleep specialist on ways to get more quality sleep. But sometimes, life can thwart the best-laid <a href="https://www.webmd.com/sleep-disorders/default.htm" data-crosslink-type="article" data-metrics-link="">sleep</a> plans. Travel, a <a href="https://www.webmd.com/parenting/baby/default.htm" data-crosslink-type="article" data-metrics-link="">newborn</a> baby, shift work, and other disruptions can get in the way of your insomnia-busting habits.</section>
<section>
<h2 id="091e9c5e80cf3382-1-2">Starting From Behind</h2>
<p>Interruptions to <a href="https://www.webmd.com/sleep-disorders/sleep-disorders-faq" data-crosslink-type="article" data-metrics-link="">sleep</a> schedules can be hard on anyone. But when you have chronic <a href="https://www.webmd.com/sleep-disorders/rm-quiz-insomnia" data-crosslink-type="tools" data-metrics-link="">insomnia</a>, you’re already behind the curve.</p>
<p>“You don’t have the same sleep reserves built up,” says Tracy Chisholm, PsyD, a behavioral sleep medicine <a href="https://www.webmd.com/mental-health/guide-to-psychiatry-and-counseling" data-crosslink-type="article" data-metrics-link="">psychologist</a> at the Portland VA Medical Center. “You’re likely to have an even harder time recovering from additional sleep disruptions because you were already struggling to operate on less than a full tank.”</p>
<p>You’re also more likely to dwell on the sleep you’re losing, which can trigger a negative feedback loop. “In other words, you worry about it more,” says Chisholm. “And guess what definitely does not help improve your sleep? Worry. This can become a vicious cycle.”</p>
</section>
<section>
<h2 id="091e9c5e80cf3382-1-3">Preparing for Disruptions</h2>
<p>There are practical steps you can take to help prevent or cope with sleep loss in situations that are out of your control. You can also try adjusting your mindset.</p>
<p>“Many times, people go into scenarios like travel assuming they’ll have difficulties with their sleep, but sometimes a change in environment can actually help you sleep better,” says Ina Djonlagic, MD, a <a href="https://www.webmd.com/brain/neurologist-facts" data-crosslink-type="article" data-metrics-link="">neurologist</a> and sleep medicine specialist at Beth Israel Deaconess Medical Center.</p>
<section>Bottom line: Don’t expect the worst, but practice good habits to prepare in case things go awry.</section>
</section>
<p>Here’s how to get back on track when certain situations mess with your sleep schedule.</p>
<section>
<h2 id="091e9c5e80cf3382-1-4">Travel and Time Changes</h2>
<p>Different time zones, strange beds in strange rooms, environments that aren’t comfortable &#8212; there are a host of ways travel can keep you from getting your ZZZs. Try these tips before your trip:</p>
<p><strong>Head off <a href="https://www.webmd.com/sleep-disorders/sleep-travel" data-crosslink-type="article" data-metrics-link="">jet lag</a>.</strong> Slowly adjust your sleep schedule at home before you leave.</p>
<p>“About a week or two before you depart, start shifting your bedtime and wake time in small increments, to more closely match your destination time zone,” says Chisholm.</p>
<section>If you’re going somewhere very far away, wait until you get there and then start by following local mealtimes and sleep times, says Chisholm. Go to bed when night comes, and get up when it’s light.<strong>Try temporary aids.</strong> Some people find low-dose <a href="https://www.webmd.com/drugs/drug-29-melatonin+oral.aspx" data-crosslink-type="article" data-metrics-link="">melatonin</a> or timed exposure to light to be helpful when they travel. “Correctly timing these interventions is key for effectiveness,” Chisholm says. “Consult with a sleep specialist if you’re interested in either of these approaches.”</section>
<section>
<h2 id="091e9c5e80cf3382-2-6">Living With a Newborn Baby</h2>
<p><a href="https://www.webmd.com/parenting/baby/video/why-babies-cry" data-metrics-link="">Babies</a> spare no one from sleep disruption. You’re at the mercy of your <a href="https://www.webmd.com/parenting/baby/ss/slideshow-baby-milestones-first-year" data-crosslink-type="slideshow" data-metrics-link="">newborn</a>’s sleep-wake cycle, which won’t be the same as yours. “Babies have much shorter sleep cycles than adults &#8212; 50 to 60 minutes, as opposed to our 90- to 110-minute cycles,” says Chisholm. Babies also need to eat every 2 to 3 hours.</p>
<p>The key is to get good sleep when you can and know things will gradually get better. You can try to:</p>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<ul>
<li>Sleep when your <a href="https://www.webmd.com/parenting/baby/rm-quiz-newborn-typical" data-crosslink-type="tools" data-metrics-link="">baby</a> sleeps.</li>
<li>Build up <a href="https://www.webmd.com/women/picture-of-the-breasts" data-crosslink-type="article" data-metrics-link="">breast</a> milk reserves by pumping between feedings, and ask a partner, friend, or family member to take over feedings when you sleep.</li>
</ul>
</section>
<section>
<h2 id="091e9c5e80cf3382-2-7">Shift Work</h2>
<p>The term “shift work” can include evening, graveyard, or early morning shifts, as well as fixed or rotating schedules. Rotating schedules that change from one day to the next tend to be the worst for sleep. Flip-flopping your days and nights can take a toll on your health.</p>
<p>“Unregulated schedules are so hard that my best advice is to try to see if you can work a different schedule that better fits healthy sleep patterns,” says Djonlagic. If that’s just not possible, you can try to:</p>
<ul>
<li>Keep the same bedtime, wake time, and mealtimes every day of the week, even on your days off. This helps keep your internal clock set around your work schedule.</li>
<li>Allow yourself enough time to wind down after work before trying to fall asleep. Don’t just come home and crash.</li>
<li>Use <a href="https://www.webmd.com/cold-and-flu/ear-infection/picture-of-the-ear" data-crosslink-type="article" data-metrics-link="">ear</a> plugs or white noise to help you fall asleep and stay asleep without interruption if you sleep during the day. You can also wear an <a href="https://www.webmd.com/eye-health/eye-assessment/default.htm" data-crosslink-type="tools" data-metrics-link="">eye</a> mask and use blackout curtains.</li>
<li>Stay ahead of <a href="https://www.webmd.com/brain/picture-of-the-brain" data-crosslink-type="article" data-metrics-link="">your brain</a>. “If your commute home happens as the sun is rising, consider wearing blue light-blocking glasses so your brain doesn’t think that you’re about to start a whole new day,” says Chisholm.<br />
<h2 id="091e9c5e80cf3382-3-8">Stress</h2>
<p><a href="https://www.webmd.com/balance/stress-management/default.htm" data-crosslink-type="article" data-metrics-link="">Stress</a> turns on your fight-or-flight response, which isn’t restful at all. In fact, it prevents sleep.</p>
<p>“From your body’s perspective, it’s like you’re trying to sleep while a saber-toothed tiger is lurking right outside your cave,” says Chisholm. She recommends these tips:</p>
<ul>
<li>Create a relaxing sleep routine that you follow every night. Make sure the final steps in this routine involve a non-stimulating activity that you enjoy. “I often recommend those with insomnia read, listen to audiobooks or calming <a href="https://www.webmd.com/balance/rm-quiz-health-benefits-music" data-crosslink-type="tools" data-metrics-link="">music</a>, or practice relaxation techniques,” says Chisholm.</li>
<li>Avoid watching the news or discussing intense topics right before bed. Doing those things can keep your mind and body from feeling relaxed.</li>
<li><a href="https://www.webmd.com/fitness-exercise/default.htm" data-crosslink-type="article" data-metrics-link="">Exercise</a> regularly, but make sure you finish at least a few hours before bedtime.</li>
<li>If you have a lot on your mind, write it down, at least an hour or so before bed, to help your brain “let it go” just for the rest of the night. You can always come back to your notes in the morning.</li>
<li>Consider seeking support from family, friends, or professionals to help you <a href="https://www.webmd.com/balance/stress-management/stress-management" data-crosslink-type="article" data-metrics-link="">manage stress</a>.</li>
</ul>
<p>“The most important thing to keep in mind is that if you already have chronic insomnia, don’t wait to get treatment &#8212; especially if you anticipate even more sleep disruptions,” says Chisholm. “Addressing chronic insomnia first can help you better cope when these common sleep disruptors occur.”</li>
</ul>
</section>
</div>
</section>
</section>
<p>Written by <a class="person" href="https://www.webmd.com/rachel-ellis">Rachel Reiff Ellis</a> <a href="https://www.webmd.com/sleep-disorders/features/reset-sleep-cycle" target="_blank" rel="noopener">source</a></p>
<p>&nbsp;</p>
<hr />
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"></h3>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>Do You Wake Up Every Night At The Same Time? This Is What It Means!</title>
		<link>https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Sat, 07 Jan 2023 20:21:14 +0000</pubDate>
				<category><![CDATA[✝️Religion✝️]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Healthy Thoughts]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Science & Engineering]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[circadian clock]]></category>
		<category><![CDATA[emotion wellbeing]]></category>
		<category><![CDATA[God's Clock]]></category>
		<category><![CDATA[healthy sleep]]></category>
		<category><![CDATA[internal clock]]></category>
		<category><![CDATA[Mental Health]]></category>
		<category><![CDATA[mind health]]></category>
		<category><![CDATA[sleep habbits]]></category>
		<category><![CDATA[waking up at night Same Time]]></category>
		<category><![CDATA[waking up at the Same Time]]></category>
		<category><![CDATA[waking up Same Time]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=8273</guid>

					<description><![CDATA[Do You Wake Up Every Night At The Same Time? This Is What It Could Mean! There are internal systems and clocks built in the body, helping us control our bodily functions. Also, it is worth mentioning that the physical and spiritual health shouldn’t be viewed separately, as they are closely related. The patterns of [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;">Do You Wake Up Every Night At The Same Time?<br />
This Is What It Could Mean!</h1>
<div class="separator">There are internal systems and clocks built in the body, helping us control our bodily functions. Also, it is worth mentioning that the physical and spiritual health shouldn’t be viewed separately, as they are closely related.</div>
<p>The patterns of energy placements to different areas of the body at different times hold special place in traditional Chinese medicine, which suggests that the body dedicates different energies to different organs within the 24 hour cycle.</p>
<div>Therefore, in case you wake up at the same time on a regular basis, it may indicate that some of your energy is getting obstructed, which in turn disrupts the natural balance. Most of these obstructions can be looked both <span style="color: #ff0000;">physically</span> and <span style="color: #3366ff;">spiritually.</span> Below you have a list of the times and organs they are associated with, which will help you identify the underlying cause of the symptoms you are experiencing.</div>
<div></div>
<div>This brings us back to spirituality and God, our creator. Even the ancients&#8230;.., that did not understand who God was at the time, knew peace in the spirit is key to internal peace and rest. Even the ancients were on to something&#8230; they were trying, searching and learning trying to better themselves like all humanity has always done.  Then Jesus was born and changed the world for all of us. The key is our happiness, our sleep and health or very closely related to God and your spirit health.</div>
<div></div>
<blockquote>
<h3 style="text-align: center;"><em><span style="color: #3366ff;">God is real</span>, <span style="color: #ff6600;">if you have not found him yet</span>, <span style="color: #3366ff;">he is waiting for you</span> </em><br />
<em>to <span style="color: #ff0000;">stop doubt</span> <span style="color: #ff00ff;">open</span> your <span style="color: #3366ff;">eyes</span> and <span style="color: #ff0000;">heart</span>!</em></h3>
</blockquote>
<h1 style="text-align: center;"><strong>WAKE UP TIMES AND WHAT THEY MEAN</strong></h1>
<h2></h2>
<h2><strong>9 pm To 11 pm</strong></h2>
<div>The period between 9 pm and 11 pm is the time when most people go to bed.  What you should know is that this is the time when the endocrine system restores its balance and the enzymes are refilling.</div>
<div>The hormones and metabolism are controlled by the endocrine system, meaning that if you have trouble falling asleep at this particular time, it is very likely that you are stuck in a flight or fight mode.  Simply put, you are either stuck with the events that happened during the day or are preparing for the upcoming day.</div>
<div>Another reason for these blockages could be a poor nutrition or a heavy meal later in the day.</div>
<div></div>
<div></div>
<h2><strong>11 pm To 1am</strong></h2>
<div>This is the time when yin energy is turned into yang, so waking up at this time on a regular basis may be due to any resentment you are stuck with.</div>
<div>
<div>Yang energy is extremely active and the body is supposed to be keeping it for the upcoming day.  To resolve this situation, it is recommended to stay calm, preserve energy, and reinforce love and positive feelings.</div>
<div>As for physical causes, it is very likely that you are eating unhealthy fats which the gallbladder has trouble breaking down.</div>
<h2></h2>
<h2><strong>1am To 3am</strong></h2>
<div>This is the time when the body is performing a detoxification and renewal process.  The liver is releasing toxins and making fresh, clean blood.  Waking up during this time could indicate negative formations like anger and frustration.  If you are neglecting these spiritual toxins,  the liver is trying to send you a massage!</div>
</div>
<div></div>
<div></div>
<div>
<h2><strong>3am To 5am</strong></h2>
<div>The period between 3 am and 5 am is the time when the lungs are undergoing repair and flood the body with oxygen.  To accelerate bodily function, you need to be warm enough.  Looking from a spiritual side, your problems with the lungs could be caused by sadness and grief.  If you keep waking up during this time, try out some breathing techniques.</div>
<div>Another cause for waking up during this time can be ascension, a process of raising your vibrational levels.  Other causes include lucid dreaming, changes in appetite, sensitivity to unusual sounds, long periods of feeling cold.</div>
<h2></h2>
<h2><strong>5am To 7am</strong></h2>
<div>The large intestine is highly active during this time, breaking down toxins and clearing them out of the body.  Waking up at this time consistently may be caused by poor diet or eating too late.</div>
</div>
<div></div>
<div><a href="https://www.awesomequotes4u.com/2017/01/do-you-wake-up-every-night-at-same-time.html" target="_blank" rel="noopener">source</a></div>
<div></div>
<div>
<hr />
</div>
<div>
<div class="top-header js-cet-subunit">
<h1 class="headline" style="text-align: center;">Here&#8217;s Why You Keep Waking Up At The Same Time Every Night</h1>
</div>
<blockquote>
<div class="dek" style="text-align: center;">Experts share what causes you to regularly wake up during sleep, plus advice on how to fix it.</div>
</blockquote>
<div class="bottom-header js-cet-subunit">
<div class="bottom-header__left">
<div class="entry__byline">
<div class="author-list" style="text-align: center;"><span aria-hidden="true">By </span><a href="https://www.huffpost.com/author/colleen-travers" target="_blank" rel="noopener">Colleen Travers</a> <a href="https://www.huffpost.com/entry/why-waking-up-same-time-night_l_5de52fbfe4b0d50f32a630dc" target="_blank" rel="noopener">source</a></div>
</div>
</div>
</div>
</div>
<div></div>
<div>
<div class="primary-cli cli cli-text ">
<p>If you’re prone to waking up in the middle of the night, this scenario is probably too familiar: You wake up, it’s pitch black and your brain immediately knows the time. Maybe it’s 3:19 a.m., maybe it’s 37 minutes before your alarm goes off. Regardless, it’s always around the same time. Suddenly your mind is active in the middle of an otherwise good night’s sleep.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>According to a global sleep survey conducted by Philips Healthcare, <a class=" js-entry-link cet-external-link" role="link" href="https://www.usa.philips.com/c-dam/b2c/master/experience/smartsleep/world-sleep-day/2019/2019-philips-world-sleep-day-survey-results.pdf" data-vars-item-name="67% of adults worldwide say they wake up at least once during the night" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://www.usa.philips.com/c-dam/b2c/master/experience/smartsleep/world-sleep-day/2019/2019-philips-world-sleep-day-survey-results.pdf" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="0">67% of adults worldwide say they wake up at least once during the night</a>. And while the occasional middle-of-the-night wake-up isn’t anything to be alarmed about, doing it consistently can affect your productivity and mood the next day. One study published in the journal Cureus found that <a class=" js-entry-link cet-external-link" role="link" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122651/" data-vars-item-name="sleep deprivation is linked to increased anger and aggression" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122651/" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="1">sleep deprivation is linked to increased anger and aggression</a>.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>So what gives? We asked sleep experts to explain what’s happening when you’re waking up at the same time every night. Read on for answers, plus tricks to get you back to sleep ― or even better, advice to help prevent you from waking up at all.</p>
<div class="primary-cli cli cli-text ">
<h3><strong>First, know that we all wake up during sleep. It’s the ‘same time’ part that is a problem.</strong></h3>
</div>
<div class="primary-cli cli cli-text ">
<p>“Everyone awakens briefly in the middle of the night multiple times ― anywhere from five to seven times ― between sleep cycles,” said <a class=" js-entry-link cet-external-link" role="link" href="https://www.drshelbyharris.com/" data-vars-item-name="Shelby Harris" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://www.drshelbyharris.com/" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="2">Shelby Harris</a>, a licensed psychologist and board-certified behavioral sleep medicine specialist in Westchester, New York, and author of ”<a class=" js-entry-link cet-external-link" role="link" href="https://www.amazon.com/Womens-Guide-Overcoming-Insomnia-Medication/dp/0393711617?tag=thehuffingtop-20&amp;ascsubtag=5de52fbfe4b0d50f32a630dc%2C-1%2C-1%2Cd%2C0%2C0%2Chp-fil-am%3D0%2C1172%3A2%3B1177%3A3%2C0%2C0%2C0" data-amazon-link="true" data-vars-item-name="The Women’s Guide to Overcoming Insomnia: Get a Good Night’s Sleep Without Relying on Medication" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://www.amazon.com/Womens-Guide-Overcoming-Insomnia-Medication/dp/0393711617?tag=thehuffingtop-20&amp;ascsubtag=5de52fbfe4b0d50f32a630dc%2C-1%2C-1%2Cd%2C0%2C0%2Chp-fil-am%3D0%2C0%3A0%2C0%2C0%2C0" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="3">The Women’s Guide to Overcoming Insomnia: Get a Good Night’s Sleep Without Relying on Medication</a>.” “It is totally normal followed by a quick return to sleep usually with amnesia for the awakening.”</p>
</div>
<div class="primary-cli cli cli-text ">
<p>But waking up frequently at the same time in the middle of the night is different, and it can mess up your sleep cycles. “When sleep isn’t consolidated, one can feel tired, sleepy and foggy during the daytime hours, in addition to getting less sleep at night and disrupting your depth of sleep,” Harris said.</p>
</div>
<div class="primary-cli cli cli-text ">
<h3><strong>Fully waking up each night may be a sign of an underlying health issue.</strong></h3>
</div>
<div class="primary-cli cli cli-text ">
<p>“People wake up in the night for many potential reasons but some are quite common,” said Mark Aloia, global lead for behavior change at <a class=" js-entry-link cet-external-link" role="link" href="https://www.usa.philips.com/healthcare" data-vars-item-name="Philips Healthcare" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://www.usa.philips.com/healthcare" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="4">Philips Healthcare</a>.</p>
</div>
<div id="newsletter-bottom" class="js-newsletter-container" data-rapid="marko-sec"></div>
<div class="primary-cli cli cli-text ">
<p>Among these reasons include insomnia (Aloia said about 80% of people with insomnia have awakenings at both the beginning and middle of the night) and obstructive sleep apnea, which is characterized by repeated interruptions in breathing during sleep that may cause someone to wake up in the middle of the night. It’s important to get these conditions ruled out by a doctor if you find yourself waking up at the same time in the middle of the night ― not just for your sleep’s sake but your overall health.</p>
<div class="primary-cli cli cli-text ">
<p>“Sleep-related disturbances like sleep apnea can lead to numerous health problems such as hypertension, heart disease, stroke and diabetes,” Aloia said. “It can increase the risk for an irregular heartbeat, worsen heart failure, and even increase the chance of having work-related or driving accidents.”</p>
</div>
</div>
</div>
</div>
<div class="img-sized__placeholder">
<div class="primary-cli cli cli-text ">
<h3><strong>If it’s not a health issue, it may be a lifestyle one.</strong></h3>
</div>
<div class="primary-cli cli cli-text ">
<p>Sad but true: As we get older, we also become lighter sleepers. “Adults tend to have less slow-wave sleep [the deepest phase of non-REM sleep], and as a result, wake up more in the middle of the night,” said Terry Cralle, a sleep expert with <a class=" js-entry-link cet-external-link" role="link" href="https://bettersleep.org/" data-vars-item-name="The Better Sleep Council" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://bettersleep.org/" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="5">The Better Sleep Council</a>.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>In addition, things like noise, lights (ahem, checking your phone when you wake up) and your diet before bed all play a part in how deeply and how long you’ll sleep during the night before waking up. “Alcohol in particular can help you fall asleep, but it invariably fragments your second half of the night,” Aloia said.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>Another issue at play that goes hand-in-hand with age? Your hormonal state, particularly for women. “Pregnancy is a time when sleep gets disrupted from hormonal changes, urination, anxiety and discomfort from a growing belly,” Harris said. “As perimenopause hits for women, hot flashes and night sweats also begin to disrupt sleep quality.</p>
<div class="primary-cli cli cli-text ">
<h3><strong>Waking up at the same time at night may be stress-related.</strong></h3>
</div>
<div class="primary-cli cli cli-text ">
<p>While there’s currently no research that explains exactly why we wake up near or around the same time of night, Aloia said it’s likely due to hypervigilance or worry.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>“Many times when we fall asleep with worries, we process these worries during certain stages of sleep,” he said. “When we wake with these worries, we have not clearly and fully processed them.”</p>
</div>
<div class="primary-cli cli cli-text ">
<p>This is why Aloia often recommends those with sleep trouble keep a worry journal next to their bed to write down what’s causing them stress and help eliminate middle-of-the-night worry sessions.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>Harris added that often anticipation of an event ― such as a baby that might cry or even the anxiety of wondering if you’ll make it through the night without waking up ― can cause lighter sleep and lead to wake-ups.</p>
<div class="primary-cli cli cli-text ">
<h3><strong>You can retrain your brain to sleep through the night.</strong></h3>
</div>
<div class="primary-cli cli cli-text ">
<p>First and foremost, it’s important to establish a healthy nightly sleep routine. That includes winding down 30 minutes to an hour before bed with no screens, keeping a consistent wake-up and sleep schedule ― even on the weekends ― and keeping the room at a comfortable temperature. (The Better Sleep Council recommends <a class=" js-entry-link cet-external-link" role="link" href="https://bettersleep.org/better-sleep/the-ideal-bedroom/" data-vars-item-name="about 65 degrees Fahrenheit" data-vars-item-type="text" data-vars-unit-name="5de52fbfe4b0d50f32a630dc" data-vars-unit-type="buzz_body" data-vars-target-content-id="https://bettersleep.org/better-sleep/the-ideal-bedroom/" data-vars-target-content-type="url" data-vars-type="web_external_link" data-vars-subunit-name="article_body" data-vars-subunit-type="component" data-vars-position-in-subunit="6">about 65 degrees Fahrenheit</a>.)</p>
</div>
<div class="primary-cli cli cli-text ">
<p>Cralle said there are also a few things you can do to specifically help yourself get back to sleep when you are waking up at the same time in the middle of the night. First, stop clock-watching.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>“A clock face should not be in your line of sight during the night, and you should not be checking your phone for the time if you do wake up,” Cralle said. “When you check the time during the night, you inevitably calculate how long you’ve been awake, and how long you have left until you need to wake up. This can easily lead to stress and anxiety and make it difficult to fall back asleep.”</p>
</div>
<div class="primary-cli cli cli-text ">
<p>It’s also important to not force sleep. It sounds counterintuitive, but it ends up being another stress-inducing activity.</p>
</div>
<div class="primary-cli cli cli-text ">
<p>“If you are not asleep in what feels to be about 15 to 20 minutes, get out of bed and do something relaxing and distracting in as dim of lighting as possible,” Cralle said. Anything from reading to listening to an audiobook, coloring, knitting, doing a puzzle, or anything else that takes your mind off sleeping will help make you feel sleepy faster. This all will eventually reduce the time you spend staring at the ceiling in place of dreaming.</p>
</div>
</div>
</div>
</div>
<p>&nbsp;</p>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA"></div>
</section>
</section>
<div>
<p>&nbsp;</p>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<hr />
<p>&nbsp;</p>
<hr />
</div>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>Sleep Could Wash Alzheimer’s Waste Out Of The Brain</title>
		<link>https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Sun, 12 Jun 2022 12:00:20 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Science & Engineering]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Women's Health]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Alzheimer's News]]></category>
		<category><![CDATA[🧠Brain Health🧠]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[Alzheimer's]]></category>
		<category><![CDATA[Brain]]></category>
		<category><![CDATA[Importance of Sleep]]></category>
		<category><![CDATA[Importance of Sleep with Alzheimer’s]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=11781</guid>

					<description><![CDATA[Explained: Sleep Could Wash Alzheimer’s Waste Out Of The Brain The Importance of Sleep with Alzheimer’s The brain is programmed to “clean mode” at night that washes away waste products. Poor sleep could make this cycle less effective and leave Alzheimer’s toxins to build up. Study findings: Researchers studied the brain of 13 participants asleep and awake. They discovered that, during deep sleep, [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 class="h1 feature-post__title" style="text-align: center;">Explained: Sleep Could Wash Alzheimer’s Waste Out Of The Brain</h1>
<h2 style="text-align: center;">The Importance of Sleep with Alzheimer’s</h2>
<h3 id="thebrainisprogrammedtocleanmodeatnightthatwashesawaywasteproductspoorsleepcouldmakethiscyclelesseffectiveandleavealzheimerstoxinstobuildup">The brain is programmed to “clean mode” at night that washes away waste products. Poor sleep could make this cycle less effective and leave Alzheimer’s toxins to build up.</h3>
<p><strong>Study findings:</strong> Researchers studied the brain of 13 participants asleep and awake. They discovered that, during deep sleep, the brain is washed by coordinated waves of cerebrospinal fluid which can remove waste products. The authors noted that these waves are not as strong in people with memory impairment, and chronic sleep problems can lead to the accumulation of beta-amyloid, a protein linked to Alzheimer’s disease.</p>
<p><strong>Why it matters:</strong> Alzheimer’s disease is the main form of dementia, and the number of people diagnosed with dementia is expected to grow by 204% worldwide by 2050. Understanding the role that sleep can play in healing the brain, and how it can be disrupted, are critical in the search for a cure and preventive measures.</p>
<p><strong>The final word:</strong> The study’s findings reveal the synchrony of processes that enable waste clearance, and suggest how this may, in the future, help to explain what role sleep quality plays in Alzheimer’s disease. The authors recommend more probing studies to identify what may influence these nocturnal cleaning “rhythms”.</p>
<h2 id="sleepthebrainshousekeeper">Sleep: the brain’s housekeeper</h2>
<p><em>Sleep flicks the switch that allows the brain to go about maintenance work without being interrupted by the pesky activity of a conscious mind.</em></p>
<p>There are several stages and depths of sleep, and you cycle through them several times per night. When you start to nod off, you are at stage 1 of non-rapid eye movement (nREM) sleep. Once you sink a bit deeper, you’re into nREM stage 2, during which your body temperature drops and your heart rate starts to slow.</p>
<div class="table">
<table>
<tbody>
<tr>
<th>Sleep cycle</th>
<th>Name</th>
</tr>
<tr>
<td>nREM stage 1</td>
<td>transition between sleep and waking</td>
</tr>
<tr>
<td>nREM stage 2</td>
<td>body temperature/heart rate drop</td>
</tr>
<tr>
<td>nREM stage 3</td>
<td>Muscles relax, blood pressure/breathing drop</td>
</tr>
<tr>
<td>REM</td>
<td>Dreaming, increased brain activity, eye movement</td>
</tr>
</tbody>
</table>
</div>
<p>Stage 3 of nREM is one we’ll discuss in this article. It is the deepest sleep: your blood pressure drops, your muscles relax, and your breathing is slowed. And this is the time your brain has set aside to clear out the waste. It’s followed by rapid-eye movement (REM) sleep when you dream, your eyes flick around, and your brain is more active. Then it all starts again.</p>
<h2 id="deepsleepdeepclean">Deep sleep, deep clean</h2>
<p><em>For many centuries, the brain had the scientific community stumped because they couldn’t figure out how it got rid of metabolic waste.</em></p>
<p>The central nervous system, which includes the brain, doesn’t have a lymphatic system like the rest of the body. Scientists found this very curious because this system is responsible for removing waste products and toxins from the body. In fact, for many centuries, it was believed that the central nervous system of mammals was simply devoid of lymphatic activity.</p>
<p><img loading="lazy" decoding="async" class="" src="https://images.unsplash.com/photo-1488642945284-f5b65425f15a?ixlib=rb-1.2.1&amp;q=80&amp;fm=jpg&amp;crop=entropy&amp;cs=tinysrgb&amp;w=1080&amp;fit=max&amp;ixid=eyJhcHBfaWQiOjExNzczfQ" alt="Drop_14" width="776" height="600" /><br />
<em>The idea of getting a cerebral spa treatment every night is appealing</em></p>
<p>However, that left an important question unanswered: how on earth does the brain rid itself of rubbish? Thanks to new technologies and determined scientists, we now know that the brain has its own way of doing things. Firstly, it does have lymphatic vessels, and they can be seen on a correctly tuned <em>magnetic resonance imaging</em> (MRI) scan.</p>
<p>But that’s not all, as this paper helpfully reminds us. The brain is much classier than initially thought: it repeatedly rinses itself in <em>cerebrospinal fluid</em> (CSF) every night. Your brain and spinal cord bathe in this clear, colourless fluid all day, and at night, waves of it surge over the brain and clear it of metabolic waste.</p>
<h2 id="ittakesthreebaby">It takes three baby</h2>
<p><em>Three synchronised actions allow the brain to clear out the byproducts of metabolism and other waste products that accumulate each day.</em></p>
<p>A team of seven researchers, led by Nina E. Fultz, looked for the missing piece of a messy puzzle that included brain waves, blood, and cerebrospinal fluid. It was already known that our thinking organ emits brain waves (tiny electrical pulses) that make our neurons fire in a specific region. The same goes for CSF — scientists already knew that it could remove metabolic waste products.</p>
<p>Yet, it was unclear whether these processes are related, and if so, what is their purpose. Fortunately, these intrepid scientists intervened to solve this nail-biting enigma. They put 13 slumbering (and sometimes, waking) people through their paces with new and old technology.</p>
<p><img loading="lazy" decoding="async" class="" src="https://images.unsplash.com/photo-1541781774459-bb2af2f05b55?ixlib=rb-1.2.1&amp;q=80&amp;fm=jpg&amp;crop=entropy&amp;cs=tinysrgb&amp;w=1080&amp;fit=max&amp;ixid=eyJhcHBfaWQiOjExNzczfQ" alt="On a very cold, gloomy weekend, after receiving some distressing news… this face." width="687" height="464" /><br />
<em>That cat is rolling in Delta waves</em></p>
<p>They attached electrodes to their subjects’ heads, measuring electric impulses on the outer layers of the brain (the <em>cortex</em>), a non-invasive technique called <em>electroencephalography</em> (EEG). Participants also underwent functional MRI scans that could show changes in cerebrospinal fluid and blood flow.</p>
<p>When the scans were in, the team compared the timing and effect of these three parameters and concluded that these features are synchronised. So, in order for the brain “washing” to function, it requires three steps. A slow brain wave breaks across a network of neurons, which triggers an increase in CSF and a decrease in blood flow (which probably makes room for the cerebrospinal fluid to wash over the brain).</p>
<h2 id="whatsitgottodowithalzheimers">What’s it got to do with Alzheimer’s?</h2>
<p><em>There are brain waves for each level of cerebral activity, and they can be disturbed in patients with specific diseases.</em></p>
<p>Brain waves coordinate levels of activity in this organ, so it should come as no surprise that they can be disturbed in different diseases. People with Alzheimer’s have fewer and smaller Delta waves, the long slow waves that occur during deep sleep (nREM stage 3), and this research may help understand why.</p>
<div class="table">
<table>
<tbody>
<tr>
<th>Wavelength/hertz</th>
<th>Brain activity</th>
</tr>
<tr>
<td>Delta (0-4 hz)</td>
<td>deep sleep</td>
</tr>
<tr>
<td>Theta (4-7 hz)</td>
<td>drowsiness, daydreaming</td>
</tr>
<tr>
<td>Alpha (7-13 hz)</td>
<td>relaxed, reflecting</td>
</tr>
<tr>
<td>Beta (13-35 hz)</td>
<td>active thinking, focus</td>
</tr>
<tr>
<td>Gamma (30-100 hz)</td>
<td>short-term memory, sensory processing</td>
</tr>
</tbody>
</table>
</div>
<p>Poor sleep quality is an important feature of Alzheimer’s, but it could be poor sleep quality and thus fewer, weaker Delta waves during a person’s lifetime that might influence clinically significant aspects, like the accumulation of specific proteins associated with this disease.</p>
<p>There are two proteins in the brain that were identified in the pathology of Alzheimer’s: beta-amyloid, which accumulates in plaques, and tau, a protein that is found in cerebrospinal fluid. Other studies have shown that wakefulness can increase levels of tau protein and that chronic sleep deprivation can increase beta-amyloid plaque accumulation.</p>
<blockquote><p><a href="https://dx.doi.org/10.1126/science.aax5440" target="_blank" rel="noopener">Read the study here</a></p></blockquote>
<p>This study postulates that disturbances in this nocturnal process of brain “cleaning” may explain why these proteins accumulate in the brain. By demonstrating that three separate actions are required for effective removal of metabolic waste during deep sleep, they suggest it might be the first step to uncovering how disturbances in this harmonious process may allow these proteins to accumulate in the first place.</p>
<p><mark>TIP<img src="https://s.w.org/images/core/emoji/17.0.2/72x72/261d.png" alt="☝" class="wp-smiley" style="height: 1em; max-height: 1em;" />The <a href="https://atlasbiomed.com/uk/dna">Atlas DNA Test</a> checks for Alzheimer’s disease risks and recommends a full night’s sleep (7-9 hours) as a preventive measure.</mark></p>
<div class="sources">
<div class="sources-header is-toggled">Sources:</div>
<ul>
<li><a href="https://science.sciencemag.org/content/366/6465/628" target="_blank" rel="noopener">NE Fultz et al., Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep, 2019</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/pubmed/30679382" target="_blank" rel="noopener">JK Holth et al., The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans, 2019</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804435/" target="_blank" rel="noopener">M Roohi-Azizi et al., Changes of the brain’s bioelectrical activity in cognition, consciousness, and some mental disorders, 2018</a></li>
</ul>
</div>
<p>&nbsp;</p>
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>What You Eat Affects How You Sleep?</title>
		<link>https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Mon, 17 Jan 2022 20:16:22 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Eating & Food Choices]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[eating]]></category>
		<category><![CDATA[eating healthy]]></category>
		<category><![CDATA[eating to live]]></category>
		<category><![CDATA[food to eat]]></category>
		<category><![CDATA[foods not to eat]]></category>
		<category><![CDATA[good sleep habbits]]></category>
		<category><![CDATA[How You Sleep]]></category>
		<category><![CDATA[rest well]]></category>
		<category><![CDATA[sleep cycle]]></category>
		<category><![CDATA[Sleep Health]]></category>
		<category><![CDATA[sleep issues]]></category>
		<category><![CDATA[What You Eat]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=8363</guid>

					<description><![CDATA[What You Eat Affects How You Sleep What You Eat Affects How You Sleep 1/10 If you could pick foods that may help you get the best sleep possible, would you? And if you knew which foods may hinder your restful slumber, would you avoid them? Now&#8217;s your chance to learn just that for a [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;">What You Eat Affects How You Sleep</h1>
<header class="slide-header inf_sliderheader">
<h2></h2>
<h2><img loading="lazy" decoding="async" class="wp-image-8371 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_woman_sleeping.jpg" alt="" width="274" height="186" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_woman_sleeping.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_woman_sleeping-300x204.jpg 300w" sizes="(max-width: 274px) 100vw, 274px" /></h2>
<h2>What You Eat Affects How You Sleep</h2>
<div class="slide-count-bbl"><strong>1</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>If you could pick foods that may help you get the best sleep possible, would you? And if you knew which foods may hinder your restful slumber, would you avoid them? Now&#8217;s your chance to learn just that for a good night&#8217;s sleep. Though the science is not solid, being mindful of what you eat and drink before bed may help.</p>
</div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<div class="caption inf_caption">
<header class="slide-header inf_sliderheader">
<h2><strong><img loading="lazy" decoding="async" class=" wp-image-8372 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/photolibrary_rm_photo_of_cheese_and_crackers.jpg" alt="" width="275" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/photolibrary_rm_photo_of_cheese_and_crackers.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/photolibrary_rm_photo_of_cheese_and_crackers-300x204.jpg 300w" sizes="(max-width: 275px) 100vw, 275px" /></strong>Indulge Your Carb Craving (a Little Bit)</h2>
<div class="slide-count-bbl" style="text-align: left;"><strong>2</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Carbohydrate-rich foods may help. So a few good late-night snacks might include a bowl of cereal and milk, nuts and crackers, or bread and cheese.</p>
</div>
</div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<div class="caption inf_caption">
<div class="caption inf_caption">
<header class="slide-header inf_sliderheader">
<h2><strong><img loading="lazy" decoding="async" class=" wp-image-8373 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_looking_in_refrigerator.jpg" alt="" width="275" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_looking_in_refrigerator.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_looking_in_refrigerator-300x204.jpg 300w" sizes="(max-width: 275px) 100vw, 275px" /></strong>Have a Snack Before Bedtime</h2>
<div class="slide-count-bbl"><strong>3</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>If you have insomnia, a little food in your stomach may help you sleep. Drinking some milk may help, too. But keep the snack small. A heavy meal will tax your digestive system, making you uncomfortable and unable to get your ZZZs.</p>
</div>
</div>
</div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p><strong><img loading="lazy" decoding="async" class="wp-image-8374 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_cheeseburger_and_fries.jpg" alt="" width="275" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_cheeseburger_and_fries.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_cheeseburger_and_fries-300x204.jpg 300w" sizes="(max-width: 275px) 100vw, 275px" /></strong></p>
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<header class="slide-header inf_sliderheader">
<h2>Limit High-Fat Foods</h2>
<div class="slide-count-bbl"><strong>4</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Research shows that people who often eat these foods gain weight and their sleep cycles tend to get disrupted. Why? A heavy meal activates digestion, which can lead to nighttime trips to the bathroom.</p>
</div>
</div>
</div>
</div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<header class="slide-header inf_sliderheader">
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8365 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_hot_chocolate.jpg" alt="" width="276" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_hot_chocolate.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_hot_chocolate-300x204.jpg 300w" sizes="(max-width: 276px) 100vw, 276px" /></strong>Beware of Hidden Caffeine</h2>
</header>
</div>
</div>
</div>
</div>
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div><strong>5</strong>/10</div>
<div class="caption inf_caption">
<p>It&#8217;s no surprise that an evening cup of coffee might disrupt your sleep. But don&#8217;t forget about less obvious caffeine sources, like chocolate, cola, and tea. Even decaf coffee has a trace of it &#8212; but not enough to be a problem. For better sleep, cut all caffeine from your diet 4 to 6 hours before bedtime.</p>
<header class="slide-header inf_sliderheader">
<h2></h2>
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8366 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_asprin_in_hand.jpg" alt="" width="275" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_asprin_in_hand.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rr_photo_of_asprin_in_hand-300x204.jpg 300w" sizes="(max-width: 275px) 100vw, 275px" /></strong>Medications May Contain Caffeine</h2>
<div></div>
<div class="slide-count-bbl"><strong>6</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Over-the-counter and prescription drugs that may have caffeine in them include pain relievers, weight loss pills, diuretics, and cold medicines. These and other medications may have as much or even more caffeine than a cup of coffee. Check the label of nonprescription drugs or the prescription drug information sheet to see if your medicine interferes with sleep or can cause insomnia.</p>
<header class="slide-header inf_sliderheader">
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8367 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_couple_watching_tv_with_wine.jpg" alt="" width="274" height="186" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_couple_watching_tv_with_wine.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_couple_watching_tv_with_wine-300x204.jpg 300w" sizes="(max-width: 274px) 100vw, 274px" /></strong>Skip the Nightcap</h2>
<div class="slide-count-bbl"><strong>7</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Alcohol may help you fall asleep faster, but you might not sleep well, waking up often, tossing and turning, and even having headaches, night sweats and nightmares. It can help to down a glass of water for each alcoholic drink, to dilute the alcohol&#8217;s effects. But for a good night&#8217;s sleep, it&#8217;s better to avoid alcohol 4 to 6 hours before bedtime.</p>
<header class="slide-header inf_sliderheader">
<h2></h2>
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8368 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_eating_chinese_food_at_computer.jpg" alt="" width="274" height="186" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_eating_chinese_food_at_computer.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_man_eating_chinese_food_at_computer-300x204.jpg 300w" sizes="(max-width: 274px) 100vw, 274px" /></strong>Beware of Heavy, Spicy Foods</h2>
<div></div>
<div class="slide-count-bbl"><strong>8</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Lying down with a full belly can make you uncomfortable, since the digestive system slows down when you sleep. It can also lead to heartburn, as can spicy cuisine. If you indulge in a heavy meal, finish it at least 4 hours before bedtime.</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<p>&nbsp;</p>
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<div class="caption inf_caption">
<header class="slide-header inf_sliderheader">
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8369 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_turning_on_light.jpg" alt="" width="275" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_turning_on_light.jpg 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rm_photo_of_turning_on_light-300x204.jpg 300w" sizes="(max-width: 275px) 100vw, 275px" /></strong>Cut the Fluids by 8 P.M.</h2>
<div class="slide-count-bbl"><strong>9</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Staying hydrated throughout the day is great for your body, but cut it off before bed. You don&#8217;t want to have to keep getting up to go to the bathroom after you turn in.</p>
<header class="slide-header inf_sliderheader">
<h2></h2>
<p>&nbsp;</p>
<h2><strong><img loading="lazy" decoding="async" class="wp-image-8370 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_man_smoking_at_night.webp" alt="" width="276" height="187" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_man_smoking_at_night.webp 652w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/getty_rf_photo_of_man_smoking_at_night-300x204.webp 300w" sizes="(max-width: 276px) 100vw, 276px" /></strong>Don&#8217;t Smoke to Relax</h2>
<div class="slide-count-bbl"><strong>10</strong>/10</div>
</header>
<div class="caption inf_caption">
<p>Even if it&#8217;s one of your favorite ways to unwind, smoking isn&#8217;t a good idea &#8212; night or day. Nicotine is a stimulant, with effects similar to caffeine. Avoid smoking before bedtime or if you wake up in the middle of the night. Keep trying to quit &#8212; it&#8217;s hard, but it&#8217;s worth it.</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p style="text-align: left;"> Medically Reviewed by <a class="person" href="https://www.webmd.com/a-to-z-guides/ambardekar-nayana" data-metrics-link="0">Nayana Ambardekar, MD</a> <a href="https://www.webmd.com/sleep-disorders/ss/slideshow-sleep-foods" target="_blank" rel="noopener">source</a></p>
<header class="&quot;centerwell-instream-head&quot;"></header>
<header class="slide-header inf_sliderheader">
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
</header>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>Circadian Rhythms &#8211; What are circadian rhythms?</title>
		<link>https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Fri, 14 Jan 2022 19:28:40 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Healthy Thoughts]]></category>
		<category><![CDATA[Men's Health]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[body clock]]></category>
		<category><![CDATA[Circadian Rhythm]]></category>
		<category><![CDATA[mood]]></category>
		<category><![CDATA[sleep cycle]]></category>
		<category><![CDATA[sleep help]]></category>
		<category><![CDATA[Sleeping Issues]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=8344</guid>

					<description><![CDATA[ Circadian Rhythms &#8211; What are circadian rhythms? ​​What are circadian rhythms? Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. These natural processes respond primarily to light and dark and affect most living things, including animals, plants, and microbes. Chronobiology is the study of circadian rhythms. One example of a light-related [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;"> Circadian Rhythms &#8211; What are circadian rhythms?</h1>
<div class="row">
<div class="col-sm-6 col-md-8">
<h3>​​What are circadian rhythms?</h3>
<p>Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. These natural processes respond primarily to light and dark and affect most living things, including animals, plants, and microbes. Chronobiology is the study of circadian rhythms. One example of a light-related circadian rhythm is sleeping at night and being awake during the day. The Average Teen Circadian Cycle image shows the circadian rhythm cycle of a typical teen.</p>
<h3>What are biological clocks?</h3>
<figure id="attachment_8345" aria-describedby="caption-attachment-8345" style="width: 500px" class="wp-caption alignright"><img loading="lazy" decoding="async" class="size-full wp-image-8345" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-cycle.png" alt="Circadian rhythm cycle of a typical teenager. Credit: NIGMS." width="500" height="475" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-cycle.png 500w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-cycle-300x285.png 300w" sizes="(max-width: 500px) 100vw, 500px" /><figcaption id="caption-attachment-8345" class="wp-caption-text"><em><span style="color: #ff6600;">Circadian rhythm cycle of a typical teenager. Credit: NIGMS.</span></em></figcaption></figure>
<p>Biological clocks are organisms’ natural timing devices, regulating the cycle of circadian rhythms. They’re composed of specific <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#196" target="_blank" rel="noopener" data-featherlight="glossary">molecules</a> (<a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#49" data-featherlight="glossary">proteins</a>) that interact with cells throughout the body. Nearly every <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#85" data-featherlight="glossary">tissue</a> and <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#27" data-featherlight="glossary">organ</a> contains biological clocks. Researchers have identified similar <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#127" data-featherlight="glossary">genes</a> in people, fruit flies, mice, plants, fungi, and several other organisms that make the clocks’ <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#202" data-featherlight="glossary">molecular</a> components.</p>
<h3>What is the master clock?</h3>
<p>A master clock in the brain coordinates all the biological clocks in a living thing, keeping the clocks in sync. In <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#201" data-featherlight="glossary">vertebrate</a> animals, including humans, the master clock is a group of about 20,000 <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#19" data-featherlight="glossary">nerve cells</a> (neurons) that form a structure called the suprachiasmatic nucleus, or SCN. The SCN is in a part of the brain called the hypothalamus and receives direct input from the eyes.</p>
</div>
<div class="col-sm-6 col-md-4 float-end">
<div class="factsheet-img-block">
<div class="mceTemp"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div class="row">
<div class="col-sm-6 col-md-4 float-start">
<div class="factsheet-img-block">
<div class="mceTemp"></div>
<p>&nbsp;</p>
</div>
</div>
<div class="col-sm-6 col-md-8">
<h3>Does the body make and keep its own circadian rhythms?</h3>
<p>Yes, natural factors in your body produce circadian rhythms. For humans, some of the most important genes in this process are the <em>Period</em> and <em>Cryptochrome</em> genes. These genes code for proteins that build up in the cell’s <a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#25" data-featherlight="glossary">nucleus</a> at night and lessen during the day. Studies in fruit flies suggest that these proteins help activate feelings of wakefulness, alertness, and sleepiness. However, signals from the environment also affect circadian rhythms. For instance, exposure to light at a different time of day can reset when the body turns on <em>Period</em> and <em>Cryptochrome</em> genes.</p>
</div>
</div>
<div class="row">
<div class="col-sm-6 col-md-6">
<h3>How do circadian rhythms affect health?</h3>
<h1 style="text-align: center;"><img loading="lazy" decoding="async" class="size-full wp-image-8353 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/Figure-2.-Light-enters-the-eyes-cdc.jpg" alt="" width="356" height="298" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/Figure-2.-Light-enters-the-eyes-cdc.jpg 356w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/Figure-2.-Light-enters-the-eyes-cdc-300x251.jpg 300w" sizes="(max-width: 356px) 100vw, 356px" /></h1>
<p>Circadian rhythms can influence important functions in our bodies, such as:</p>
<ul>
<li><a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#142" data-featherlight="glossary">Hormone</a> release</li>
<li>Eating habits and digestion</li>
<li>Body temperature</li>
</ul>
<p>However, most people notice the effect of circadian rhythms on their sleep patterns. The SCN controls the production of melatonin, a hormone that makes you sleepy. It receives information about incoming light from the optic nerves, which relay information from the eyes to the brain. When there is less light—for example, at night—the SCN tells the brain to make more melatonin so you get drowsy.</p>
</div>
<div class="col-md-6">
<div class="row factsheet-callout">
<h3>Nobel Prize</h3>
<div class="col-md-8">
<p>In 2017, researchers Jeffrey C. Hall, Michael Rosbash, and Michael W. Young won the prestigious Nobel Prize for their circadian rhythms research. By studying fruit flies, which have a very similar genetic makeup to humans, they isolated a gene that helps control the body’s clock. The scientists showed that the gene produces a protein that builds up in cells overnight, then breaks down during the day. This process can affect when you sleep, how sharply your brain functions, and more. All three researchers were funded by NIGMS when these major discoveries were made.</p>
</div>
<div class="col-md-4">
<div class="factsheet-img-block">
<figure id="attachment_8347" aria-describedby="caption-attachment-8347" style="width: 676px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" class=" wp-image-8347" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/fruit-fly-brain.jpg" alt="Circadian rhythm neurons in the fruit fly brain. Credit: Matthieu Cavey and Justin Blau, New York University" width="676" height="524" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/fruit-fly-brain.jpg 968w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/fruit-fly-brain-300x232.jpg 300w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/fruit-fly-brain-768x595.jpg 768w" sizes="(max-width: 676px) 100vw, 676px" /><figcaption id="caption-attachment-8347" class="wp-caption-text"><em><span style="color: #ff6600;">Circadian rhythm neurons in the fruit fly brain. Credit: Matthieu Cavey and Justin Blau, New York University</span></em></figcaption></figure>
<p>&nbsp;</p>
</div>
</div>
</div>
</div>
</div>
<div class="row">
<div class="col-md-4">
<div class="factsheet-img-block">
<figure id="attachment_8348" aria-describedby="caption-attachment-8348" style="width: 684px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" class="size-full wp-image-8348" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-melatonin.jpg" alt="Melatonin is a hormone that makes you sleepy. Credit: iStock" width="684" height="435" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-melatonin.jpg 684w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-melatonin-300x191.jpg 300w" sizes="(max-width: 684px) 100vw, 684px" /><figcaption id="caption-attachment-8348" class="wp-caption-text"><em><span style="color: #ff6600;">Melatonin is a hormone that makes you sleepy. Credit: iStock</span></em></figcaption></figure>
<p>&nbsp;</p>
</div>
</div>
<div class="col-md-8">
<h3>What factors can change circadian rhythms?</h3>
<p>Changes in our body and environmental factors can cause our circadian rhythms and the natural light-dark cycle to be out of sync. For example:</p>
<ul>
<li>Mutations or changes in certain genes can affect our biological clocks.</li>
<li>Jet lag or shift work causes changes in the light-dark cycle.</li>
<li>Light from electronic devices at night can confuse our biological clocks.</li>
</ul>
<p>These changes can cause sleep disorders, and may lead to other chronic health conditions, such as obesity, diabetes, depression, bipolar disorder, and seasonal affective disorder.</p>
</div>
</div>
<div class="row">
<div class="col-md-8">
<h3>How are circadian rhythms related to jet lag?</h3>
<p>When you pass through different time zones, your biological clock will be different from the local time. For example, if you fly east from California to New York, you “lose” 3 hours. When you wake up at 7:00 a.m. on the East Coast, your biological clock is still running on West Coast time, so you feel the way you might at 4:00 a.m. Your biological clock will reset, but it will do so at a different rate. It often takes a few days for your biological clock to align with a new time zone. Adjusting after “gaining” time may be slightly easier than after “losing” time because the brain adjusts differently in the two situations.</p>
<h3>How do researchers study circadian rhythms?</h3>
<p>Scientists learn about circadian rhythms by studying humans and by using organisms with similar biological clock genes, such as fruit flies and mice. Researchers doing these experiments control the subject’s environment by altering light and dark periods. Then they look for changes in gene activity or other molecular signals. Scientists also study organisms with irregular circadian rhythms to identify which genetic components of biological clocks may be broken.</p>
<p>Understanding what makes biological clocks tick may lead to treatments for jet lag, sleep disorders, obesity, mental health disorders, and other health problems. It can also improve ways for people to adjust to nighttime shift work. Learning more about the genes responsible for circadian rhythms will also help us understand more about the human body.</p>
</div>
<div class="col-md-4">
<div class="factsheet-img-block">
<figure id="attachment_8349" aria-describedby="caption-attachment-8349" style="width: 1000px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" class="size-full wp-image-8349" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-timezones.jpg" alt="Traveling across time zones disrupts your circadian rhythms. Credit: iStock" width="1000" height="480" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-timezones.jpg 1000w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-timezones-300x144.jpg 300w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/circadian-timezones-768x369.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px" /><figcaption id="caption-attachment-8349" class="wp-caption-text"><em><span style="color: #ff6600;">Traveling across time zones disrupts your circadian rhythms. Credit: iStock</span></em></figcaption></figure>
<p><a href="https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#:~:text=%E2%80%8B%E2%80%8BWhat%20are%20circadian,the%20study%20of%20circadian%20rhythms." target="_blank" rel="noopener">source</a></p>
</div>
</div>
</div>
<hr />
<h1 style="text-align: center;">Circadian Rhythm</h1>
<p style="text-align: center;"><a class="person" href="https://www.webmd.com/stephanie-booth">Stephanie Booth</a> <a href="https://www.webmd.com/sleep-disorders/find-circadian-rhythm" target="_blank" rel="noopener">source</a></p>
<section>Although you won’t hear it tick, your body has its own clock. The physical and mental changes it causes are called <a href="https://www.webmd.com/balance/features/power-of-circadian-rhythms" data-crosslink-type="article" data-metrics-link="">circadian rhythms</a>. Most living things have them, including animals, plants, and even some germs.Circadian rhythms affect your <a href="https://www.webmd.com/sleep-disorders/default.htm" data-crosslink-type="article" data-metrics-link="">sleep</a> patterns as well as other ways your body works, like your hormones, body temperature, and eating habits. When they get out of sync, they might also cause problems with your health. They’ve been linked to different disorders including <a href="https://www.webmd.com/diabetes/default.htm" data-crosslink-type="article" data-metrics-link="">diabetes</a>, <a href="https://www.webmd.com/diet/obesity/features/am-i-obese" data-crosslink-type="article" data-metrics-link="">obesity</a>, and <a href="https://www.webmd.com/depression/default.htm" data-crosslink-type="article" data-metrics-link="">depression</a>.To get good, healthy <a href="https://www.webmd.com/sleep-disorders/ss/slideshow-sleep-disorders-overview" data-crosslink-type="slideshow" data-metrics-link="">sleep</a>, it helps to know what keeps your body’s clock on track and what might throw its rhythm off.</section>
<section>
<h2 id="091e9c5e81bb054e-1-2">How Circadian Rhythms Work</h2>
<p>About 20,000 nerve cells make up your “master clock,” a part of <a href="https://www.webmd.com/brain/picture-of-the-brain" data-crosslink-type="article" data-metrics-link="">your brain</a> called the suprachiasmatic nucleus. This structure, which sits inside an area called the <a href="https://www.webmd.com/brain/hypopituitary" data-crosslink-type="article" data-metrics-link="">hypothalamus</a>, controls your circadian rhythms. While largely guided by your genes and other natural factors inside your body, things in the outside world can also alter them.</p>
<section>The biggest cue is light. Your body is wired to <a href="https://www.webmd.com/sleep-disorders/sleep-habits-assessment" data-crosslink-type="tools" data-metrics-link="">sleep</a> when it’s dark and stay awake when it’s light outside. Nerves directly link your <a href="https://www.webmd.com/eye-health/picture-of-the-eyes" data-crosslink-type="article" data-metrics-link="">eyes</a> and your body’s master clock. When daylight fades, your <a href="https://www.webmd.com/eye-health/ss/slideshow-eye-conditions-overview" data-crosslink-type="slideshow" data-metrics-link="">eyes</a> signal your brain to make more <a href="https://www.webmd.com/drugs/drug-29-melatonin+oral.aspx" data-crosslink-type="article" data-metrics-link="">melatonin</a>, a <a href="https://www.webmd.com/women/features/escape-hormone-horrors-what-you-can-do" data-crosslink-type="article" data-metrics-link="">hormone</a> that makes you feel sleepy. And when the sun rises again, the signals tell the brain to turn down the melatonin.Circadian rhythms work by helping to make sure that the <span class="source-shortcode d-inline" data-source-index="1"><a class="source-link position-relative is-trusted" href="https://www.nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx" target="_blank" rel="noopener nofollow" data-source-id="83553" data-source-index="1"><span class="source-text">body’s processes are optimized at various points during a 24-hour period </span></a><span class="source-card-wrapper"><span id="source-1" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Institute of General Medical Sciences (NIGMS)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.</span><a class="source-domain font-weight-light d-block" href="https://www.nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx" target="_blank" rel="noopener nofollow">nigms.nih.gov</a></span></span></span></span>. The term circadian <span class="source-shortcode d-inline" data-source-index="2"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/25635592/" target="_blank" rel="noopener nofollow" data-source-id="78995" data-source-index="2"><span class="source-text">comes from the Latin phrase “circa diem,” </span></a><span class="source-card-wrapper"><span id="source-2" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/25635592/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>which means “around a day.”Circadian rhythms exist in all types of organisms. For example, they help flowers open and close at the right time and <span class="source-shortcode d-inline" data-source-index="3"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/11584554/" target="_blank" rel="noopener nofollow" data-source-id="80069" data-source-index="3"><span class="source-text">keep nocturnal animals from leaving their shelter </span></a><span class="source-card-wrapper"><span id="source-3" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/11584554/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>during the daytime when they would be exposed to more predators.In people, <span class="source-shortcode d-inline" data-source-index="4"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/26600101/" target="_blank" rel="noopener nofollow" data-source-id="78606" data-source-index="4"><span class="source-text">circadian rhythms coordinate mental and physical systems </span></a><span class="source-card-wrapper"><span id="source-4" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/26600101/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>throughout the body. The digestive system <span class="source-shortcode d-inline" data-source-index="5"><a class="source-link position-relative is-trusted" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/tick-tock-new-clues-about-biological-clocks-and-health.aspx" target="_blank" rel="noopener nofollow" data-source-id="82987" data-source-index="5"><span class="source-text">produces proteins </span></a><span class="source-card-wrapper"><span id="source-5" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Institute of General Medical Sciences (NIGMS)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.</span><a class="source-domain font-weight-light d-block" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/tick-tock-new-clues-about-biological-clocks-and-health.aspx" target="_blank" rel="noopener nofollow">nigms.nih.gov</a></span></span></span></span>to match the typical timing of meals, and the endocrine system regulates hormones to suit normal energy expenditure.The circadian rhythms throughout the body are <span class="source-shortcode d-inline" data-source-index="6"><a class="source-link position-relative is-trusted" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/The-Rhythms-of-Life.aspx" target="_blank" rel="noopener nofollow" data-source-id="82986" data-source-index="6"><span class="source-text">connected to a master clock, </span></a><span class="source-card-wrapper"><span id="source-6" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Institute of General Medical Sciences (NIGMS)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.</span><a class="source-domain font-weight-light d-block" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/The-Rhythms-of-Life.aspx" target="_blank" rel="noopener nofollow">nigms.nih.gov</a></span></span></span></span>sometimes referred to as the circadian pacemaker, located in the brain. Specifically, it is found in the suprachiasmatic nucleus (SCN), which is in a part of the brain called the hypothalamus. At different times of the day, <span class="source-shortcode d-inline" data-source-index="7"><a class="source-link position-relative is-trusted" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/Resetting-Our-Clocks-New-Details-About-How-the-Body-Tells-Time.aspx" target="_blank" rel="noopener nofollow" data-source-id="82985" data-source-index="7"><span class="source-text">clock genes </span></a><span class="source-card-wrapper"><span id="source-7" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Institute of General Medical Sciences (NIGMS)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.</span><a class="source-domain font-weight-light d-block" href="https://www.nigms.nih.gov/education/Inside-Life-Science/Pages/Resetting-Our-Clocks-New-Details-About-How-the-Body-Tells-Time.aspx" target="_blank" rel="noopener nofollow">nigms.nih.gov</a></span></span></span></span>in the SCN send signals to regulate activity throughout the body.The SCN is highly sensitive to light, which serves as a critical external cue that influences the signals sent by the SCN to coordinate internal clocks in the body. For this reason, circadian rhythms are closely connected to day and night. While other cues, like exercise, social activity, and temperature, can affect the master clock, light is the most powerful influence on circadian rhythms.</p>
<h3 class="wp-block-heading">Is a Circadian Rhythm the Same As a Biological Clock?</h3>
<p>Biological clocks help regulate the timing of bodily processes, including circadian rhythms. A circadian rhythm is an effect of a biological clock, but not all biological clocks are circadian. For instance, plants adjust to changing seasons using a biological clock with timing that is distinct from a 24-hour cycle.</p>
<h2 id="how-does-circadian-rhythm-affect-sleep--2" class="wp-block-heading">How Does Circadian Rhythm Affect Sleep?</h2>
<p>When people talk about circadian rhythm, it’s most often in the context of sleep. The <a href="https://www.sleepfoundation.org/circadian-rhythm/sleep-drive-and-your-body-clock">sleep-wake cycle</a> is one of the most clear and critical examples of the importance of circadian rhythms.</p>
<p>During the day, light exposure causes the master clock to send <span class="source-shortcode d-inline" data-source-index="8"><a class="source-link position-relative is-trusted" href="http://healthysleep.med.harvard.edu/healthy/science/how/neurophysiology" target="_blank" rel="noopener nofollow" data-source-id="78221" data-source-index="8"><span class="source-text">signals that generate alertness </span></a><span class="source-card-wrapper"><span id="source-8" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-left"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">Division of Sleep Medicine at Harvard Medical School</strong><span class="source-description d-block font-size-xs line-height-sm my-2">A production of WGBH Educational Foundation and the Harvard Medical School Division of Sleep Medicine.</span><a class="source-domain font-weight-light d-block" href="http://healthysleep.med.harvard.edu/healthy/science/how/neurophysiology" target="_blank" rel="noopener nofollow">healthysleep.med.harvard.edu</a></span></span></span></span>and help keep us awake and active. As night falls, the master clock initiates the production of <a href="https://www.sleepfoundation.org/melatonin">melatonin</a>, a hormone that promotes sleep, and then keeps transmitting signals that help us stay asleep through the night.</p>
<p>In this way, our circadian rhythm <span class="source-shortcode d-inline" data-source-index="9"><a class="source-link position-relative is-trusted" href="http://healthysleep.med.harvard.edu/healthy/science/how/internal-clock" target="_blank" rel="noopener nofollow" data-source-id="78220" data-source-index="9"><span class="source-text">aligns our sleep and wakefulness with day and night </span></a><span class="source-card-wrapper"><span id="source-9" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">Division of Sleep Medicine at Harvard Medical School</strong><span class="source-description d-block font-size-xs line-height-sm my-2">A production of WGBH Educational Foundation and the Harvard Medical School Division of Sleep Medicine.</span><a class="source-domain font-weight-light d-block" href="http://healthysleep.med.harvard.edu/healthy/science/how/internal-clock" target="_blank" rel="noopener nofollow">healthysleep.med.harvard.edu</a></span></span></span></span>to create a stable cycle of restorative rest that enables increased daytime activity.</p>
</section>
<section>
<h2 id="091e9c5e81bb054e-1-3">Different Patterns for Different People</h2>
<p>You’ve likely noticed that you feel more alert during certain parts of the day and have lower energy at others. This pattern has to do with your “chronotype,” or personal circadian rhythm. They vary from person to person, although they tend to run in families.</p>
<p>Most of the time, people fall into one of two groups:</p>
<p><strong>Early birds:</strong> If you find it easy to wake up in the morning and feel you have the most energy early in the day, you’re a morning person or a “lark.” Some research suggests that an early bird’s body clock may run slightly faster than 24 hours.</p>
<section><strong>Night owls:</strong> If you’re an evening person, some research suggests that your body clock runs slower than 24 hours. You’ll find it hard to wake up in the mornings and feel alert. You’ll have the most energy much later in the day, like 11 p.m.Your chronotype isn’t set in stone, though. Circadian rhythms naturally change as you age. For example, the body clock shifts during adolescence, making <a href="https://teens.webmd.com/default.htm" data-crosslink-type="article" data-metrics-link="">teens</a> want to go to bed later and sleep longer than younger kids.Your work or school schedule may mean that you need to switch from a night owl to an early bird. You can try to alter your circadian rhythm yourself, but do it slowly. For example, try waking up 15 minutes earlier each morning over the course of a week.</section>
<section>
<h2 id="091e9c5e81bb054e-2-5">Circadian Rhythms Out of Sync</h2>
<p>Small changes can upset your circadian rhythms. These include:</p>
<p><strong>Extra sleep. </strong>Your body clock works best when you stick to a schedule. In an ideal world, you’ll go to sleep and wake up within a half hour of the same time each day, even on weekends.</p>
<p><strong>Travel. </strong>When you pass through time zones, you can adjust your watch but not your body clock. It will try to function on the time it is at your home, a problem you may know as jet lag. The more time zones you pass through, the more off you may feel. Your body clock will reset to the new time you’re in, but it can take a few days.</p>
<p><strong>Screen time. </strong>Any amount of light signals your brain that it’s time to be up and alert. Even the blue light from your tablet, smartphone, or TV has this effect. To get a good night’s sleep, unplug from all screens 2 to 3 hours before bed. Other artificial light can have the same effect, so turn off hallway lights and face your alarm clock away from you. If you’re bothered by light outside your home, put up blackout curtains or use a sleep mask.</p>
<p><strong>Night shifts. </strong>If you work nights, you’ll need to sleep during the day. This can be tough since your body is programmed to be awake when it’s light outside. Over time, you can start to have what’s called shift work disorder. You’ll find it hard to stay awake at night, yet struggle to sleep during the day. Naps during the day or your night shift can help.</p>
<p><strong>Your period. </strong>Many women notice that they sleep worse before their period starts. This may be due, at least in part, to a change in circadian rhythms. Some studies show that <em>less </em>sleep during this time can reset your body clock and give some relief. Bright daylight or light therapy may also make a difference.</p>
<h2 id="what-does-circadian-rhythm-affect-besides-sleep--3" class="wp-block-heading">What Does Circadian Rhythm Affect Besides Sleep?</h2>
<p>While the sleep-wake cycle is one of the most prominent circadian rhythms, these 24-hour internal clocks play a vital role in <span class="source-shortcode d-inline" data-source-index="10"><a class="source-link position-relative is-trusted" href="https://biobeat.nigms.nih.gov/2014/10/4-timely-facts-about-our-biological-clocks/" target="_blank" rel="noopener nofollow" data-source-id="78279" data-source-index="10"><span class="source-text">virtually all systems of the body </span></a><span class="source-card-wrapper"><span id="source-10" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Institute of General Medical Sciences (NIGMS) Blog</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.</span><a class="source-domain font-weight-light d-block" href="https://biobeat.nigms.nih.gov/2014/10/4-timely-facts-about-our-biological-clocks/" target="_blank" rel="noopener nofollow">biobeat.nigms.nih.gov</a></span></span></span></span>.</p>
<p>Research continues to uncover details about circadian rhythms, but <span class="source-shortcode d-inline" data-source-index="11"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/28977444/" target="_blank" rel="noopener nofollow" data-source-id="78175" data-source-index="11"><span class="source-text">evidence has connected them </span></a><span class="source-card-wrapper"><span id="source-11" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/28977444/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>to metabolism and weight through the regulation of blood sugar and cholesterol. Circadian rhythms influence mental health as well, including the risk of psychiatric illnesses like <a href="https://www.sleepfoundation.org/mental-health/depression-and-sleep">depression</a> and bipolar disorder as well as the potential for <span class="source-shortcode d-inline" data-source-index="12"><a class="source-link position-relative is-trusted" href="https://medlineplus.gov/degenerativenervediseases.html" target="_blank" rel="noopener nofollow" data-source-id="79781" data-source-index="12"><span class="source-text">neurodegenerative diseases </span></a><span class="source-card-wrapper"><span id="source-12" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">Medline Plus</strong><span class="source-description d-block font-size-xs line-height-sm my-2">MedlinePlus is an online health information resource for patients and their families and friends.</span><a class="source-domain font-weight-light d-block" href="https://medlineplus.gov/degenerativenervediseases.html" target="_blank" rel="noopener nofollow">medlineplus.gov</a></span></span></span></span>like <a href="https://www.sleepfoundation.org/mental-health/dementia-and-sleep">dementia</a>.</p>
<p>There are indications that circadian rhythms have an important influence on the immune system as well as processes of DNA repair that are <span class="source-shortcode d-inline" data-source-index="13"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/25302769/" target="_blank" rel="noopener nofollow" data-source-id="78763" data-source-index="13"><span class="source-text">involved in preventing cancer </span></a><span class="source-card-wrapper"><span id="source-13" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/25302769/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>. Early-stage research indicates that circadian cycles can <span class="source-shortcode d-inline" data-source-index="14"><a class="source-link position-relative is-trusted" href="https://www.cancer.gov/news-events/cancer-currents-blog/2018/targeting-circadian-clock-cancer" target="_blank" rel="noopener nofollow" data-source-id="82319" data-source-index="14"><span class="source-text">influence the effectiveness of anti-cancer drugs </span></a><span class="source-card-wrapper"><span id="source-14" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Cancer Institute (NCI)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The NCI is the federal government&#8217;s principal agency for cancer research and training.</span><a class="source-domain font-weight-light d-block" href="https://www.cancer.gov/news-events/cancer-currents-blog/2018/targeting-circadian-clock-cancer" target="_blank" rel="noopener nofollow">cancer.gov</a></span></span></span></span>and that new medications may be able to harness biological clocks to kill cancer cells.</p>
<h2 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading">What Happens When Circadian Rhythm Is Off?</h2>
<p>When circadian rhythm is thrown off, it means that the body’s systems don’t function optimally.</p>
<p>A disturbed sleep-wake circadian rhythm can give rise to serious sleeping problems. Without the proper signaling from the body’s internal clock, a person can struggle to fall asleep, wake up during the night, or be unable to sleep as long as they want into the morning. Their total sleep can be reduced, and a disrupted circadian rhythm can also mean shallower, fragmented, and lower-quality sleep.<strong><span id="authors-toggle" class="modal-trigger text-neutral-dark"><a href="https://www.sleepfoundation.org/about-us/eric-suni" target="_blank" rel="noopener">Eric Suni</a>, Staff Writer</span></strong> <a href="https://www.sleepfoundation.org/circadian-rhythm" target="_blank" rel="noopener">source</a></p>
</section>
</section>
</section>
<h2 id="what-can-disrupt-circadian-rhythm--5" class="wp-block-heading">What Can Disrupt Circadian Rhythm?</h2>
<p>Disruptions to circadian rhythm can occur over the short- or long-term. Experts have identified a number of types of circadian rhythm sleep-wake disorders (CRSWD) based on their characteristics and causes.</p>
<ul>
<li><a href="https://www.sleepfoundation.org/travel-and-sleep/jet-lag"><b>Jet Lag</b></a><b> Disorder:</b> This occurs when a person crosses multiple time zones in a short period of time and gets its name from the fact that it is often experienced by people who take intercontinental flights. Until a person’s circadian rhythm can acclimate to the day-night cycle of their new location, they are likely to suffer sleeping problems and fatigue from jet lag.</li>
<li><a href="https://www.sleepfoundation.org/shift-work-disorder/what-shift-work"><b>Shift Work</b></a><b> Disorder:</b> Work obligations can cause major disruptions in a person’s circadian rhythm. Shift work, which requires having to work through the night and sleep during the day, puts a person’s sleep schedule directly at odds with the local daylight hours.</li>
<li><b>Advanced Sleep Phase Disorder:</b> People with this type of disruption find that they get tired early in the evening and wake up very early in the morning. Even if they want to be up later at night or sleep later in the morning, people with an advanced sleep phase disorder usually cannot do so. This disorder is relatively rare, <span class="source-shortcode d-inline" data-source-index="16"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/17395535/" target="_blank" rel="noopener nofollow" data-source-id="78618" data-source-index="16"><span class="source-text">affecting around 1% of people in middle and older age </span></a><span class="source-card-wrapper"><span id="source-16" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span><a id="source-card-close-16" class="source-card-close-icon p-2 text-align-right" data-role="button" aria-role="close" data-source-index="16"></a></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/17395535/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>, and occurs more frequently in older adults. In some cases, advanced sleep phase disorder may be related to an inherited genetic cause.</li>
<li><b>Delayed Sleep Phase Disorder:</b> This type of circadian rhythm disruption is associated with “night owls” who stay up late at night and sleep in late in the morning. It is rare among the general population — affecting just 1 or 2 people out of every 1,000 — but impacts up to 16% of <a href="https://www.sleepfoundation.org/teens-and-sleep">teens</a>. The exact cause is unknown but may be related to genetics, underlying physical conditions, and a person’s behavior.</li>
<li><a href="https://www.sleepfoundation.org/non-24-sleep-wake-disorder"><b>Non-24 Hour Sleep Wake Disorder:</b></a> This condition occurs <span class="source-shortcode d-inline" data-source-index="17"><a class="source-link position-relative is-trusted" href="https://rarediseases.org/rare-diseases/non-24-hour-sleep-wake-disorder/" target="_blank" rel="noopener nofollow" data-source-id="82239" data-source-index="17"><span class="source-text">primarily in people who are blind </span></a><span class="source-card-wrapper"><span id="source-17" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span><a id="source-card-close-17" class="source-card-close-icon p-2 text-align-right" data-role="button" aria-role="close" data-source-index="17"></a></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Organization for Rare Disorders (NORD)</strong><span class="source-description d-block font-size-xs line-height-sm my-2">NORD is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them.</span><a class="source-domain font-weight-light d-block" href="https://rarediseases.org/rare-diseases/non-24-hour-sleep-wake-disorder/" target="_blank" rel="noopener nofollow">rarediseases.org</a></span></span></span></span>and are not able to receive light-based cues for their circadian rhythm. Their body still follows a 24-hour cycle, but their sleeping hours constantly shift backward by minutes or hours at a time.</li>
<li><b>Irregular Sleep-Wake Rhythm Disorder:</b> People with this rare disorder have no consistent pattern to their sleep and may have many naps or short sleeping periods throughout a 24-hour day. It is <span class="source-shortcode d-inline" data-source-index="18"><a class="source-link position-relative is-trusted" href="https://pubmed.ncbi.nlm.nih.gov/20160950/" target="_blank" rel="noopener nofollow" data-source-id="78561" data-source-index="18"><span class="source-text">frequently connected to conditions that affect the brain </span></a><span class="source-card-wrapper"><span id="source-18" class="card source-card border-radius-none border border-primary position-absolute bg-neutral-light source-card-right"><span class="card-header bg-neutral-light border-0 d-flex justify-content-between"><span class="trusted-label font-size-sm"><a class="text-gray-dark font-weight-medium text-decoration-none" href="https://www.sleepfoundation.org/editorial-policy">Trusted Source</a></span><a id="source-card-close-18" class="source-card-close-icon p-2 text-align-right" data-role="button" aria-role="close" data-source-index="18"></a></span><span class="card-body pt-0 d-block"><strong class="source-title d-block">National Library of Medicine, Biotech Information</strong><span class="source-description d-block font-size-xs line-height-sm my-2">The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.</span><a class="source-domain font-weight-light d-block" href="https://pubmed.ncbi.nlm.nih.gov/20160950/" target="_blank" rel="noopener nofollow">pubmed.ncbi.nlm.nih.gov</a></span></span></span></span>, such as dementia or traumatic brain injury, that limit the proper functioning of the master clock in the hypothalamus.</li>
</ul>
<p>As this list demonstrates, there are diverse causes of circadian rhythm disorders. Some circadian disruptions are related to individual behavior, such as for travel or work, that puts sleep schedules out of whack with normal daylight exposure. Other disorders stem from an underlying issue that causes an inability to receive or process environmental cues that regulate the body’s master clock. In certain situations, genetic causes may be involved, or the cause may remain unknown.</p>
<h2 id="how-to-maintain-a-healthy-circadian-rhythm-6" class="wp-block-heading">How To Maintain a Healthy Circadian Rhythm</h2>
<p>While we don’t have full control over our circadian rhythm, there are <a href="https://www.sleepfoundation.org/sleep-hygiene/healthy-sleep-tips">healthy sleep tips</a> that can be taken to try to better entrain our 24-hour sleep cycles.</p>
<div class="wp-block-image is-style-default infographic-desktop">
<figure class="aligncenter size-large is-resized"><img loading="lazy" decoding="async" class="size-large wp-image-8358 aligncenter" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/2f3nx9w_SF_DataViz-8-SleepWake-Desktop-1536x1062-1-1024x708.png" alt="" width="640" height="443" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/2f3nx9w_SF_DataViz-8-SleepWake-Desktop-1536x1062-1-1024x708.png 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2f3nx9w_SF_DataViz-8-SleepWake-Desktop-1536x1062-1-300x207.png 300w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2f3nx9w_SF_DataViz-8-SleepWake-Desktop-1536x1062-1-768x531.png 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2f3nx9w_SF_DataViz-8-SleepWake-Desktop-1536x1062-1.png 1536w" sizes="(max-width: 640px) 100vw, 640px" /></figure>
</div>
<div class="wp-block-spacer" aria-hidden="true"></div>
<ul>
<li><b>Seek out sun:</b> Exposure to natural light, especially early in the day, helps reinforce the strongest circadian cue.</li>
<li><b>Follow a consistent sleep schedule:</b> Varying your bedtime or morning wake-up time can hinder your body’s ability to adjust to a stable circadian rhythm.</li>
<li><b>Get daily exercise:</b> Activity during the day can support your internal clock and help make it easier to fall asleep at night.</li>
<li><b>Avoid caffeine:</b> Stimulants like <a href="https://www.sleepfoundation.org/nutrition/caffeine-and-sleep">caffeine</a> can keep you awake and throw off the natural balance between sleep and wakefulness. Everyone is different, but if you’re having trouble sleeping, you should avoid caffeine after noon.</li>
<li><b>Limit light before bed:</b> Artificial light exposure at night can interfere with circadian rhythm. Experts advise dimming the lights and putting down <a href="https://www.sleepfoundation.org/how-sleep-works/how-electronics-affect-sleep">electronic devices</a> in the lead-up to bedtime and keeping electronics out of the bedroom and away from your <a href="https://www.sleepfoundation.org/best-mattress">mattress</a>.</li>
<li><b>Keep naps short and early in the afternoon:</b> Late and long naps can push back your bedtime and throw your sleep schedule off-kilter.</li>
</ul>
<p>These steps to improve <a href="https://www.sleepfoundation.org/sleep-hygiene">sleep hygiene</a> can be an important part of supporting a healthy circadian rhythm, but other steps may be necessary depending on the situation. If you have persistent or severe sleeping problems, daytime drowsiness, and/or a problematic sleep schedule, it’s important to talk with a doctor who can best diagnose the cause and offer the most appropriate treatment.</p>
<div id="block_533eb581e4ab99d0699808a152074ed3" data-block-name="acf/block-quotes">
<div class="blockquote-5 my-4 w-100 border-left pl-4">
<div class="ocm-head font-weight-medium mb-2">Related News</div>
<ul class="ocm-list position-relative">
<li style="list-style-type: none;">
<ul class="ocm-list position-relative">
<li class="pl-4 mb-3"><a href="https://www.nature.com/articles/s41467-022-34704-9" target="_blank" rel="noopener">Daylight Saving Time Affects Mortality Patterns in European Countries</a><br />
<em>November 14, 2022</em> – Analysis of the impact of daylight saving time on people in 16 European countries from 1998 to 2012 shows a decrease in mortality in the spring and an increase in the fall in the two weeks after each daylight saving time change.</li>
</ul>
</li>
</ul>
<ul class="ocm-list position-relative">
<li style="list-style-type: none;">
<ul class="ocm-list position-relative">
<li class="pl-4 mb-3"><a href="https://www.congress.gov/bill/117th-congress/senate-bill/623/all-info" target="_blank" rel="noopener">Bill to Make Daylight Saving Time Permanent Stuck in House</a><br />
<em>November 4, 2022</em> – The U.S. Senate passed legislation in March to make daylight saving time permanent, but the Sunshine Protection Act of 2021 is still stalled in the House of Representatives.</li>
</ul>
</li>
</ul>
<ul class="ocm-list position-relative">
<li style="list-style-type: none;">
<ul class="ocm-list position-relative">
<li class="pl-4 mb-3"><a href="https://www.cell.com/current-biology/fulltext/S0960-9822(22)01615-3" target="_blank" rel="noopener">Permanent Daylight Saving Time Would Reduce Deer-Vehicle Collisions</a></li>
</ul>
</li>
</ul>
<ul class="ocm-list position-relative">
<li class="pl-4 mb-3"><a href="https://aasm.org/aasm-experts-advocate-for-permanent-standard-time-ahead-of-fall-back/" target="_blank" rel="noopener">Sleep Experts Advocate for Permanent Standard Time</a><br />
<em>Listed news articles do not represent the opinion of Good Shepherd Media and are provided for informational purposes only.</em></li>
</ul>
</div>
</div>
<p>&nbsp;</p>
<hr />
<h1 class="h1 feature-post__title" style="text-align: center;">Circadian Rhythm: What Is It And How To Reset Your Body Clock?</h1>
<p><img loading="lazy" decoding="async" class="alignnone size-large wp-image-11766" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112--1024x589.png" alt="" width="640" height="368" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112--1024x589.png 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112--400x230.png 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112--768x442.png 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112--1536x883.png 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/2021-01-11-Energy-210112-.png 2000w" sizes="(max-width: 640px) 100vw, 640px" /></p>
<div class="article__content">
<div class="article__content-left text">
<h3 id="humanshaveclockgenesthatmakethebodyticklikeawelloiledmachinelearnaboutyourcircadianrhythmandhowitaffectsyourhealthanddiseaserisks">Humans have clock genes that make the body tick like a well-oiled machine. Learn about your circadian rhythm and how it affects your health and disease risks.</h3>
<p>&nbsp;</p>
<p>A circadian rhythm is a 24-hour biological clock that affects your sleep, digestion, and metabolism. When your circadian rhythm is disrupted, it can even increase your disease risks.</p>
<p>The circadian rhythm is a body clock that organises all the biological processes necessary for life. It is dictated by clock genes that trigger essential metabolic activities, like storing energy, transporting oxygen, getting rid of waste, and releasing hormones and neurotransmitters.</p>
<h3 id="tableofcontents">Table of contents</h3>
<ul>
<li><a href="#what-is-it">What is a circadian rhythm?</a></li>
<li><a href="#how-it-works">How the circadian cycle works</a></li>
<li><a href="#reset">Do you need to reset your body clock?</a></li>
<li><a href="#health">Circadian rhythm and health</a></li>
<li><a href="#fix-your-sleep">How to fix your sleep schedule</a></li>
</ul>
<hr />
<p>Even though you can’t see or feel this clock, circadian health is essential for your health and wellbeing. In this article, you’ll discover what happens when the cycle rhythm is disrupted, how to reset your body clock, and how to fix your sleep schedule.</p>
<h2 id="whatisacircadianrhythmanamewhatisita">What is a circadian rhythm?<a name="what-is-it"></a></h2>
<p>&nbsp;</p>

<p>The circadian rhythm is a 24-hour clock that dictates millions of invisible metabolic processes that keep the body alive. It determines digestive rhythms, fat burning and fat storage, sleeping patterns, and much more. This biological rhythm is run by clock genes that signal when each process should take place.</p>
<div class="custom-quote">Approximately 20% of genes turn on and off during the 24-hour cycle.</div>
<p>Going to bed late, playing with your phone at midnight, eating late in the evening, and working night shifts are all factors that can shift your circadian cycle. Scientific evidence now indicates that circadian rhythm disruptions are associated with serious, but preventable, chronic diseases like diabetes type II, heart disease, obesity, stroke, and cancers.</p>
<h3 id="howthecircadiancycleworksanamehowitworksa">How the circadian cycle works<a name="how-it-works"></a></h3>
<p>&nbsp;</p>
<figure><img loading="lazy" decoding="async" class="alignnone size-large wp-image-11765" src="https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-1024x848.png" alt="" width="640" height="530" srcset="https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-1024x848.png 1024w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-400x331.png 400w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-768x636.png 768w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-1536x1271.png 1536w, https://goodshepherdmedia.net/wp-content/uploads/2023/01/Circadian-rhythm-chart-Atlas-Biomed-1-1-2048x1695.png 2048w" sizes="(max-width: 640px) 100vw, 640px" /><figcaption>A circadian rhythm chart can help you optimise your daily activities</figcaption></figure>
<p>The circadian rhythm is made up of a set of clocks and a central “master clock”, called the suprachiasmatic nucleus (SCN). The SCN is located in the hypothalamus, the part of the brain responsible for regulating stress, reproduction, and growth hormones. It also indirectly impacts sleep hormones.</p>
<p>The body’s clock contains about 20,000 cells, which are located just above the intersection of the optic nerves. The cycle rhythm is set by signals from special melanopsin cells in the retina in response to light exposure. Blue light (from bright daylight, phone screens, and TVs) has the strongest effect on melanopsin receptors, followed by green and red light.</p>
<div class="custom-quote">The circadian rhythm reacts to light: it wakes you up, and it puts you to sleep by triggering cascades of chemical events in your brain.</div>
<div class="footnote-wrapper">
<p>Body clock genes have been discovered in nearly every organ of the human body. These genes turn on and off at predictable times, switching on and shutting down the production of proteins that perform essential functions within the body’s cells.</p>
<div class="footnote"><a href="https://atlasbiomed.com/blog/explained-sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener"><img loading="lazy" decoding="async" class="" src="https://atlasbiomed.com/blog/content/images/2021/01/Science-bites--NEW-orange.png" alt="Science-bites--NEW-orange" width="647" height="372" /></a></div>
<h3 class="footnote"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">Sleep washes Alzheimer’s particles from the brain</a></h3>
</div>
<p>&nbsp;</p>
<p>Interestingly, studies show that blind mice and blind people still have active melanopsin receptors that regulate their biological clock. This helps to explain why patients suffering from blindness can “sense” light, even if they can’t see it.</p>
<p><mark><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/261d.png" alt="☝" class="wp-smiley" style="height: 1em; max-height: 1em;" /><strong>Find out more about your genes<img src="https://s.w.org/images/core/emoji/17.0.2/72x72/261d.png" alt="☝" class="wp-smiley" style="height: 1em; max-height: 1em;" /></strong> Take the <a href="https://atlasbiomed.com/uk/dna">Atlas DNA Test</a> to explore how your genetic make-up affects your health and wellbeing.</mark></p>
<h2 id="doyouneedabodyclockresetanamereseta">Do you need a body clock reset?<a name="reset"></a></h2>
<p>&nbsp;</p>
<p>Sleeping at irregular times, using devices, eating late at night, and other pernicious habits displace the cycle rhythm. When a person’s biological cycle isn’t on schedule, it causes a wide range of minor health issues that can affect everyday life.</p>
<p>Low energy, mood swings, food cravings, weak immunity, and having trouble losing weight are common side effects of circadian disruption according to <a href="https://www.salk.edu/scientist/satchidananda-panda/">Professor Satchidananda Panda</a>, author of the Circadian Code.</p>
<div class="table">
<table>
<thead>
<tr>
<th>Area</th>
<th>Common problems</th>
</tr>
</thead>
<tbody>
<tr>
<td>Sleep</td>
<td>Difficulty falling or staying asleep, sleeping too much</td>
</tr>
<tr>
<td>Weight</td>
<td>Weight gain, inability to lose weight</td>
</tr>
<tr>
<td>Vitality</td>
<td>Low energy, reliance on caffeinated products</td>
</tr>
<tr>
<td>Diet</td>
<td>Late-night food cravings, stomach cramps &amp; indigestion</td>
</tr>
<tr>
<td>Mood</td>
<td>Depression, emotional outbursts &amp; irrational anger</td>
</tr>
<tr>
<td>Immunity</td>
<td>Weak immune system, frequent illness &amp; infections</td>
</tr>
</tbody>
</table>
</div>
<h3 id="circadianrhythmanddigestionanamehealtha">Circadian rhythm and digestion<a name="health"></a></h3>
<p>&nbsp;</p>
<p>The digestive system secretes the most gastric juices, enzymes, and hormones in the first half of the day. This activity reduces as the afternoon progresses into evening. These molecules are all essential for healthy digestion, which is why eating late at night can cause indigestion.</p>
<h3 id="circadianrhythmandsleep">Circadian rhythm and sleep</h3>
<p>&nbsp;</p>
<figure><img loading="lazy" decoding="async" class="" src="https://images.unsplash.com/photo-1575203091586-611fe505bb0e?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=MXwxMTc3M3wwfDF8c2VhcmNofDJ8fGNsb2NrfGVufDB8fHw&amp;ixlib=rb-1.2.1&amp;q=80&amp;w=2000" alt="Your circadian rhythm is run by clock genes by Moritz Kindler for Unsplash." width="554" height="369" /><figcaption>Your circadian rhythm is run by clock genes</figcaption></figure>
<p>At night, the circadian rhythm is focused on putting the body to sleep, removing waste products, and repairing tissues from the wear-and-tear of daytime activities. In fact, sleep is the only time for the brain to remove the waste products of chemical reactions.</p>
<blockquote><p>When you mess with your sleep schedule, or deprive yourself of sleep, you impair the brain’s ability to operate at maximum efficiency.</p></blockquote>
<h3 id="circadianrhythmanddisease">Circadian rhythm and disease</h3>
<p>&nbsp;</p>
<p>Living out of sync with the body’s circadian rhythm over the short and long term is associated with serious, chronic, and preventable diseases that affect the body’s metabolism, according to a 2016 systematic review on the “<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314421/" target="_blank" rel="noopener">Interaction between circadian rhythms and stress</a>”.</p>
<div class="footnote-wrapper">
<p>In one referenced study, the human participants with impaired circadian rhythm function had “higher blood glucose and insulin levels as well as elevated blood pressure, which are markers for metabolic and cardiovascular disease.”</p>
<div class="footnote"></div>
</div>
<p>The study’s summary of its effects on night shift workers demonstrated that such professionals have “a higher incidence of obesity, diabetes type II and related metabolic disturbances along with hypertension (high blood pressure), coronary heart disease, and ischemic stroke”.</p>
<h2 id="howtofixyoursleepscheduleanamefixyoursleepa">How to fix your sleep schedule<a name="fix-your-sleep"></a></h2>
<p>&nbsp;</p>
<p>Light and darkness are the main determinants in circadian rhythm. When daylight or screen light is detected by your eyes, it sends signals to the suprachiasmatic nucleus, which regulates all the clock genes in your body.</p>
<p>To reset your body clock, you need to put yourself on a schedule that respects your body’s metabolic rhythm. While this may be impossible for night shift workers, it is an achievable goal for people with day jobs.</p>
<ul>
<li><strong>Go to bed and get up at the same time every day.</strong></li>
<li><strong>Turn off TV screens, phones, and tablets 1-2 hours before bed.</strong></li>
<li><strong>Eat your biggest meal early in the day when digestive juices are highest.</strong></li>
<li><strong>Stay away from caffeinated beverages in the afternoon and evening.</strong></li>
<li><strong>Cut down on alcohol at night because it affects sleep quality.</strong></li>
<li><strong>Stop eating at least 3 hours before bed to avoid indigestion.</strong></li>
<li><strong>Get blackout curtains and dim light bulbs for your bedroom.</strong></li>
</ul>
<div class="sources">
<div class="sources-header is-toggled">Sources:</div>
<ul>
<li>[Sachin Panda, The Circadian Code]</li>
<li><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314421/" target="_blank" rel="noopener">Koch C.E. et al., Interaction between Circadian Rhythm and Stress 2017</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/pubmed/12015981" target="_blank" rel="noopener">S. Panda et al., Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock</a></li>
<li><a href="https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side" target="_blank" rel="noopener">Blue light has a dark side</a></li>
<li><a href="https://www.nigms.nih.gov/Education/Pages/Factsheet_CircadianRhythms.aspx" target="_blank" rel="noopener">Circadian rhythms fact sheet</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954516/" target="_blank" rel="noopener">Thomas C. Erren et al., Shift Work and Cancer 2010</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/pubmed/30264707" target="_blank" rel="noopener">Bennett J.E. et al. (2018). NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.4</a></li>
</ul>
</div>
</div>
</div>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" style="text-align: center;" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<hr />
<p>&nbsp;</p>
</div>
</section>
<h3 style="text-align: center;"></h3>
]]></content:encoded>
					
		
		
			</item>
		<item>
		<title>GABA and L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says</title>
		<link>https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/</link>
		
		<dc:creator><![CDATA[The Truth News]]></dc:creator>
		<pubDate>Sat, 08 Jan 2022 08:32:10 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Healthy Living]]></category>
		<category><![CDATA[Physical Health]]></category>
		<category><![CDATA[Sleep]]></category>
		<category><![CDATA[Top Stories]]></category>
		<category><![CDATA[Zee Truthful News]]></category>
		<category><![CDATA[🧠Psychology / Mental Health🧠]]></category>
		<category><![CDATA[Brain Health]]></category>
		<category><![CDATA[mood]]></category>
		<category><![CDATA[Mood Health]]></category>
		<category><![CDATA[Sleep Health]]></category>
		<category><![CDATA[sleep issues]]></category>
		<category><![CDATA[Sleep Poblems]]></category>
		<category><![CDATA[stress]]></category>
		<category><![CDATA[Supplements]]></category>
		<category><![CDATA[Vitamins]]></category>
		<guid isPermaLink="false">https://goodshepherdmedia.net/?p=4625</guid>

					<description><![CDATA[GABA and L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says Abstract Context: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABAA receptors favours sleep. l-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits. Objective: This study investigated the [&#8230;]]]></description>
										<content:encoded><![CDATA[<h1 style="text-align: center;">GABA and L-theanine mixture Improves<br />
REM Sleep, Antidepressant, and Mood-stabilizing Study Says</h1>
<div id="abstract-1" class="tsec sec" lang="en">
<h2 id="abstract-1title" class="head no_bottom_margin ui-helper-clearfix">Abstract</h2>
<div>
<p id="p-2" class="p p-first"><strong>Context:</strong> γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABA<sub>A</sub> receptors favours sleep. <span class="small-caps">l</span>-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits.</p>
<p id="p-3"><strong>Objective:</strong> This study investigated the potential synergistic sleep enhancement effect of GABA/<span class="small-caps">l</span>-theanine mixture.</p>
<p id="p-4"><strong>Materials and methods:</strong> Pentobarbital-induced sleep test was applied to find proper concentration for sleep-promoting effect in ICR mice. Electroencephalogram (EEG) analysis was performed to investigate total sleeping time and sleep quality in normal SD rats and caffeine-induced awareness model. Real-time polymerase chain reaction (RT-PCR) was applied to investigate whether the sleep-promoting mechanism of GABA/<span class="small-caps">l</span>-theanine mixture involved transcriptional processes.</p>
<p id="p-5"><strong>Results:</strong> GABA/<span class="small-caps">l</span>-theanine mixture (100/20 mg/kg) showed a decrease in sleep latency (20.7 and 14.9%) and an increase in sleep duration (87.3 and 26.8%) compared to GABA or theanine alone. GABA/<span class="small-caps">l</span>-theanine mixture led to a significant increase in rapid eye movement (REM) (99.6%) and non-REM (NREM) (20.6%) compared to controls. The use of GABA/<span class="small-caps">l</span>-theanine mixture rather than GABA or <span class="small-caps">l</span>-theanine alone restored to normal levels sleep time and quality in the arousal animal model. The administration of GABA/<span class="small-caps">l</span>-theanine led to increased expression of GABA and the glutamate GluN1 receptor subunit.</p>
<p id="p-6" class="p p-last"><strong>Conclusions:</strong> GABA/<span class="small-caps">l</span>-theanine mixture has a positive synergistic effect on sleep quality and duration as compared to the GABA or <span class="small-caps">l</span>-theanine alone. The increase in GABA receptor and GluN1 expression is attributed to the potential neuromodulatory properties of GABA/<span class="small-caps">l</span>-theanine combination, which seems to affect sleep behaviour.</p>
</div>
<div class="sec"><strong class="kwd-title">Keywords: </strong><span class="kwd-text">γ-Aminobutyric acid, insomnia, pentobarbital-induced sleep test, electroencephalography</span></div>
</div>
<div id="s0001" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="s0001title" class="head no_bottom_margin ui-helper-clearfix">Introduction</h2>
<p id="p-7" class="p p-first">Sleep loss and other related disturbances pose an important health problem, as they can lead to significant functional impairments. Sleep disturbances can affect daily life considerably and reduce the quality of life. The importance of a good night’s sleep is well-established, nevertheless many people suffering from sleep disorders prefer not to use hypnotic drugs, despite providing effective symptomatic relief.</p>
<p id="p-8">Hypnotic drugs, such as benzodiazepine analogues, zolpidem and doxepin, can cause unexpected side effects and can lead to drug resistance and dependence (Longo and Johnson <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0028" aria-expanded="false" aria-haspopup="true">2000</a>; Victorri-Vigneau et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0038" aria-expanded="false" aria-haspopup="true">2007</a>; Lichstein et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0026" aria-expanded="false" aria-haspopup="true">2013</a>). These types of sleeping drugs are not suitable for the treatment of temporary anxiety or sleep disturbances due to the observed drug resistance and dependence that has been associated with their long-term use (Oh et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0031" aria-expanded="false" aria-haspopup="true">2010</a>). However, herbal remedies have been reported as effective and with a relatively low side effect risk for the treatment of insomnia (Wheatley <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0039" aria-expanded="false" aria-haspopup="true">2005</a>). Therefore, it is necessary to develop new bioactive substances derived from natural sources that present with similar efficacy but fewer side effects than hypnotic drugs, for the successful treatment of sleep-related disturbances.</p>
<p id="p-9">γ-Glutamylethylamine, also known as <span class="small-caps">l</span>-theanine, and γ-aminobutyric acid (GABA) are known agents for improving sleep disturbances (Khan et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0018" aria-expanded="false" aria-haspopup="true">2018</a>). GABA is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. Hence GABA<sub>A</sub> receptors are a primary target in the search for natural anxiolytic compounds or sedatives (Khom et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0019" aria-expanded="false" aria-haspopup="true">2007</a>; Trauner et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0036" aria-expanded="false" aria-haspopup="true">2008</a>). There is an increasing interest in investigating the effect of GABA-mediated inhibitory neurotransmission, in respect to its potential benefit on counteracting sleep disruption caused by various conditions, such as stress, diseases and caffeine intake, etc. (Wong et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0040" aria-expanded="false" aria-haspopup="true">2003</a>). Therefore, GABA is widely used in functional food and pharmaceutical industries, and various researches have been investigated for biosynthesis and their efficacy as metabolites of plants and microorganisms produced by the decarboxylation of glutamic acid (Coda et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0005" aria-expanded="false" aria-haspopup="true">2010</a>; Dhakal et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0008" aria-expanded="false" aria-haspopup="true">2012</a>; Yang et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0043" aria-expanded="false" aria-haspopup="true">2018</a>) <span class="small-caps">l-</span>Theanine, an amino acid exclusively found in tea leaves, composes only 1–2% (w/w) of the weight of dried tea leaves (Graham <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0010" aria-expanded="false" aria-haspopup="true">1992</a>) and is chemically or biologically synthesized for use as an active ingredient that induces sedation (Juneja et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0014" aria-expanded="false" aria-haspopup="true">1999</a>; Yan et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0041" aria-expanded="false" aria-haspopup="true">2003</a>). There are several reports indicating that <span class="small-caps">l</span>-theanine exerts neuroprotective effects (Kim et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0020" aria-expanded="false" aria-haspopup="true">2009</a>), modulates neurotransmitter activity (Kakuda <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0015" aria-expanded="false" aria-haspopup="true">2011</a>) and reduces psychological stress (Kimura et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0021" aria-expanded="false" aria-haspopup="true">2007</a>) and sleep disturbances (Jang et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0012" aria-expanded="false" aria-haspopup="true">2012</a>). Nathan et al. (<a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0030" aria-expanded="false" aria-haspopup="true">2006</a>) also reported that <span class="small-caps">l</span>-theanine intake increases serotonin, dopamine and GABA levels in the brain.</p>
<p id="p-10" class="p p-last">In recent years, there have been numerous ‘relaxation beverages’ available on the market containing relaxation-inducing nutraceuticals, such as valerian, <span class="small-caps">l</span>-theanine, GABA, 5-hydroxytryptophan (5-HTP) and the sleep-aid, melatonin. Therefore, the combination of GABA and <span class="small-caps">l</span>-theanine may synergistically promote symptomatic relief for sleep disorders, despite the scarce experimental data supporting this process. The purpose of this study was to investigate whether the effect of GABA/<span class="small-caps">l</span>-theanine mixture on sleep disturbances is greater than GABA or <span class="small-caps">l</span>-theanine alone and to determine the most effective dosing combination.</p>
</div>
<div id="s0002" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="s0002title" class="head no_bottom_margin ui-helper-clearfix">Materials and methods</h2>
<div id="s0003" class="sec sec-first">
<h3 id="s0003title">Materials</h3>
<p id="p-11" class="p p-first-last">GABA (90.8%) and <span class="small-caps">l</span>-theanine (99.3%) was supplied by Neo Cremar Co. Ltd (Seoul, Korea) and BTC Co. Ltd (Ansan, Korea), respectively. Caffeine was purchased from Sigma-Aldrich (St. Louis, MO) and pentobarbital sodium was purchased from Hypharm. Co. Ltd. (Gyeonggi-do, Korea). All other reagents were purchased at the highest commercial grade available.</p>
</div>
<div id="s0004" class="sec">
<h3 id="s0004title">Animals</h3>
<p id="p-12" class="p p-first-last">Male ICR mice (4 weeks old, 18–20 g) and Sprague-Dawley (SD) rats (8 weeks old, 160–180 g) were purchased from Orient Bio (Orient Bio Inc., Seongnam, Korea). All animals were caged at 22 ± 2 °C and 55 ± 5% humidity with a 12 h light/dark cycle. Normal pellet diet and water were freely provided. Rodents were acclimatized for at least one week before starting pentobarbital-induced sleep testing and electroencephalography (EEG) analysis. The ages of the animals used in this study were to ensure the functional integrity of the brain and central nervous system, which usually does not occur in older animals, which normally have degraded morphological and functional characteristics (Verdú et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0037" aria-expanded="false" aria-haspopup="true">2000</a>). In this study, all animal experimental protocols were approved by the Korean University Animal Care Committee (KUIACUC-2017-49, Seoul, Korea).</p>
</div>
<div id="s0005" class="sec">
<h3 id="s0005title">Pentobarbital-induced sleep test</h3>
<p id="p-13" class="p p-first-last">Pentobarbital-induced sleep was performed according to previously established methods with slight modifications (Yang et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0042" aria-expanded="false" aria-haspopup="true">2013</a>). Sodium pentobarbital (42 mg/kg) was administered intraperitoneally in each mouse 40 min after oral administration of GABA, <span class="small-caps">l</span>-theanine or both (GABA/<span class="small-caps">l</span>-theanine). The time elapsed from compound administration to the loss of righting reflex (sleep latency) and the time from the loss of righting reflex to its return (sleep duration) were measured in seconds. Mice that did not sleep 15 min after the injection were excluded from the experiment.</p>
</div>
<div id="s0006" class="sec">
<h3 id="s0006title">Electrophysiological analysis</h3>
<p id="p-14" class="p p-first-last">Male SD rats were anesthetized with 2% isoflurane (Troikaa Pharmaceutical Ltd., Gujarat, India), using a gas anesthesia mask in a stereotaxic instrument frame (Stoelting Inc., Wood Dale, IL). For the EEG recording, EEG screw electrodes were implanted into the cortex, striatum and hippocampus, as previously described (Hong et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0011" aria-expanded="false" aria-haspopup="true">2016</a>). All rats received antibiotics and were kept individually in cages under a temperature-controlled facility with water and food. The rats were randomly divided into control and treatment groups at 7 days after recovery. Experiments were conducted from 10 am to 5 pm for 9 days. GABA, <span class="small-caps">l</span>-theanine or GABA/<span class="small-caps">l</span>-theanine mixture was orally administered 1 h before EEG signal analysis. EEG signals were amplified, filtered (0.5–30 Hz), recorded and stored using Iox2 (version. 2.8.0.13, emka Technologies, Paris, France). EEG spectra were analyzed in 1 Hz frequency bins and standard frequency bands (β: 13–30 Hz; α: 8–13 Hz; θ: 4–8 Hz; δ: 0.5–4 Hz). After the EEG recording, fast Fourier transform (FFT) was performed every 2 sec. Based on the FFT average data obtained at 10-sec intervals in the range of 0–30 Hz, the ecgAUTO3 program (version. 3.3.0.20, emka Technologies) was used to calculate the awake and sleep time. Caffeine (10 mg/kg) was used to induce the arousal condition before the experiments.</p>
</div>
<div id="s0007" class="sec">
<h3 id="s0007title">Quantification of receptor mRNA levels</h3>
<p id="p-15" class="p p-first-last">Total RNA was extracted from mouse brains using TRIzol® (Invitrogen, CA), while genomic DNA was removed using Direct-zolTM RNA Miniprep (ZYMO Research, CA) according to the manufacturer’s protocol. Quality-controlled RNA (1 μg) was reverse transcribed using SuperScript® III Reverse Transcriptase (Invitrogen) with oligo d(T) as the primer. The generated cDNA was subjected to quantitative real-time PCR (qRT-PCR) using a Power Taqman PCR Master Mix kit (Applied Biosystems, Foster City, CA). For qRT-PCR, cycling conditions were 50 °C for 2 min, 95 °C for 10 min, followed by 40 cycles at 95 °C for 15 s and 60 °C for 1 min. Quantitative analysis was conducted using StepOne plus Software version 2.0 (Applied Biosystems, Inc., Foster City, CA). The endogenous housekeeping gene, GAPDH (NM_008084.2), was used for result normalization. Information for the target genes used for qRT-PCR is as follows: GABA<sub>A</sub> receptor (<a id="__tag_1112488977" class="tag_hotlink" href="https://www.ncbi.nlm.nih.gov/nuccore/NM_008076.3">NM_008076.3</a>), GABA<sub>B</sub> receptor 1 (NM_01 9439.3), GABA<sub>B</sub> receptor 2 (NM_001081141.1), GluA1 (NM_00111 3325.2), GluN1 (<a id="__tag_1112488976" class="tag_hotlink" href="https://www.ncbi.nlm.nih.gov/nuccore/NM_001177656.2">NM_001177656.2</a>) and GluN2A (NM_008170.2).</p>
</div>
<div id="s0008" class="sec sec-last">
<h3 id="s0008title">Statistical analysis</h3>
<p id="p-16" class="p p-first-last">Testing results were evaluated for statistical differences using SPSS version 12.0 (SPSS, Chicago, IL) by one-way analysis of variance (ANOVA) followed by both Tukey’s multiple comparisons and Bonferroni <em>post hoc</em> test. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among groups by Tukey’s multiple comparison tests. All data are expressed as the means ± standard error (SE) comparisons between groups, <em>n</em> = 8.</p>
</div>
</div>
<div id="s0009" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="s0009title" class="head no_bottom_margin ui-helper-clearfix">Results</h2>
<div id="s0010" class="sec sec-first">
<h3 id="s0010title">Effects of GABA and <span class="small-caps">l</span>-theanine on sleep latency and duration in the pentobarbital-induced sleep model</h3>
<p id="p-17" class="p p-first">Sleep latency and duration time following GABA or <span class="small-caps">l</span>-theanine administration were measured in the pentobarbital-included sleep model to identify the optimal combination ratio for sleep enhancement (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1</a>). Sleep latency showed a tendency to decrease with increasing GABA concentration and sleep duration to increase with increasing GABA concentration (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1(A,B)</a>). Regarding sleep latency, there was a significant difference (<em>p</em> &lt; 0.05) following the administration of 100 mg/kg of GABA (3.1 min), as compared to control (3.7 min), but no significant differences with other GABA concentrations were observed (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1(A)</a>). With regards to sleep duration, there was also a significant difference (<em>p</em> &lt; 0.05) following 100 mg/kg of GABA, as compared to control. No significant differences of sleep duration were observed following the administration of any other GABA concentrations (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1(B)</a>). Pentobarbital-induced sleep testing was carried out to assess the potential sleep enhancement effect of <span class="small-caps">l</span>-theanine (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1(C,D)</a>). Following the administration of 20 or 30 mg/kg of <span class="small-caps">l</span>-theanine, sleep latency significantly decreased (2.8 and 2.7 min, respectively), as compared to controls (3.7 min) (<em>p</em> &lt; 0.05 and <em>p</em> &lt; 0.01, respectively). However, the administration of 40 mg/kg of <span class="small-caps">l</span>-theanine not decreased sleep latency (3.7 min). When compared to controls (39.9 min), total sleep time increased in <span class="small-caps">l</span>-theanine-treated animals at a dose of 20 mg/kg (55.2 min), but not with 30 or 40 mg/kg of <span class="small-caps">l</span>-theanine (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1(D)</a>, <em>p</em> &lt; 0.01). In summary, administration of 20 mg/kg of <span class="small-caps">l</span>-theanine in mice, resulted in a decrease in sleep latency (23.3%) and an increase in sleep duration time (38.1%).</p>
<div id="F0001" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078691631760">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p>&nbsp;</p>
</div>
<div id="lgnd_F0001" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0001/" target="figure" rel="noopener">Figure 1.</a></div>
<div class="caption">
<p id="p-18">Effects of GABA or <span class="small-caps">l</span>-theanine on sleep latency (A, C) and sleep duration (B, D) in mice administered with a hypnotic dosage of pentobarbital (42 mg/kg, i.p.). Values are presented as the means ± standard error (SE) for each group, <em>n</em> = 8. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among samples by Tukey’s multiple range test. Symbols indicate significant differences by Bonferroni test, as **<em>p</em> &lt; 0.01, *<em>p</em> &lt; 0.05.</p>
</div>
</div>
</div>
</div>
<div id="s0011" class="sec">
<h3 id="s0011title">Effects of GABA/<span class="small-caps">l</span>-theanine combination on sleep latency and duration in the pentobarbital-induced sleep model</h3>
<p id="p-19" class="p p-first">The induced changes in sleep latency and duration time by different ratio combinations of GABA (80 and 100 mg/kg) and <span class="small-caps">l</span>-theanine (20 and 30 mg/kg) were measured (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0002/" target="figure" rel="noopener">Figure 2</a>). The sleep latency of animals that were administered with either of the GABA/<span class="small-caps">l</span>-theanine dose combinations (80/30 and 100/20 mg/kg) was slightly lower than the control group (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0002/" target="figure" rel="noopener">Figure 2(A)</a>) (16.8 and 17.7%, respectively). With respect to sleep duration, sleep time showed a tendency increase in all dose combination groups (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0002/" target="figure" rel="noopener">Figure 2(B)</a>). In particular, the GABA/<span class="small-caps">l</span>-theanine mixture administered at a dose ratio of 100/20 mg/kg, evoked the highest sleep duration increase (100.6 min) (<em>p</em> &lt; 0.01).</p>
<div id="F0002" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078696263184">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p><img loading="lazy" decoding="async" class="size-full wp-image-4627 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0002_C.jpg" alt="" width="718" height="505" srcset="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0002_C.jpg 718w, https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0002_C-300x211.jpg 300w" sizes="(max-width: 718px) 100vw, 718px" /></p>
</div>
<div id="lgnd_F0002" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0002/" target="figure" rel="noopener">Figure 2.</a></div>
<div class="caption">
<p id="p-20">Effects of GABA/<span class="small-caps">l</span>-theanine mixture on sleep latency (A, C) and sleep duration (B, D) in mice administered with a hypnotic dosage of pentobarbital (42 mg/kg, i.p.). Values are presented as the means ± standard error (SE) for each group, <em>n</em> = 8. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among samples by Tukey’s multiple range test. Symbols indicate significant differences by Bonferroni test, as **<em>p</em> &lt; 0.01, *<em>p</em> &lt; 0.05.</p>
</div>
</div>
</div>
<p id="p-21" class="p p-last">The effects of the best sleep-promoting GABA/<span class="small-caps">l</span>-theanine dose combination (100/20 mg/kg) were compared to the changes in sleep latency and duration induced by the single administration of GABA or <span class="small-caps">l</span>-theanine (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0002/" target="figure" rel="noopener">Figure 2(C,D)</a>). The combined use of GABA/<span class="small-caps">l</span>-theanine (100/20 mg/kg) showed a decrease in sleep latency (20.7% and 14.9%, respectively) and an increase in sleep duration (87.3% and 26.8%, respectively) compared to a single administration of GABA (100 mg/kg) or theanine (20 mg/kg). The combined use of GABA/<span class="small-caps">l</span>-theanine showed synergy effects on sleep latency and sleep duration time.</p>
</div>
<div id="s0012" class="sec">
<h3 id="s0012title">Effects of GABA and <span class="small-caps">l</span>-theanine mixture on sleep architecture</h3>
<p id="p-22" class="p p-first">EEG parameters were recorded to more accurately confirm the synergistic effect of GABA/<span class="small-caps">l</span>-theanine mixture observed in the pentobarbital-induced sleep model (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3</a>). The changes in sleep time and architecture were measured after a single administration of GABA 100 mg/kg or <span class="small-caps">l</span>-theanine 20 mg/kg and after GABA/<span class="small-caps">l</span>-theanine mixture (100/20 mg/kg). <a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3</a> depicts the longest sleep time recorded following the oral administration of GABA/<span class="small-caps">l</span>-theanine. However, no significant difference in sleep time was detected between GABA/<span class="small-caps">l</span>-theanine mixture and <span class="small-caps">l</span>-theanine alone (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(A)</a>). The most reduced awake time was detected after oral administration of GABA/<span class="small-caps">l</span>-theanine mixture (1.2 h) and was significantly different from control (2.2 h) (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(B)</a>, <em>p</em> &lt; 0.001). Single GABA administration (100 mg/kg) significantly increased rapid-eye-movement (REM) sleep time, as compared to the control group (71.5%) (<em>p</em> &lt; 0.01), but there was no significant difference in non-REM (NREM) sleep time compared to the control group (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(C,D)</a>). Single <span class="small-caps">l</span>-theanine administration (20 mg/kg) significantly increased REM time, when compared to controls (88.6%) (<em>p</em> &lt; 0.01), but there was no significant difference in NREM sleep time compared to the control group. NREM (20.7%) and REM (99.6%) were also significantly increased than control levels, after GABA/<span class="small-caps">l</span>-theanine mixture was orally administered (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(C,D)</a>, <em>p</em> &lt; 0.05 and <em>p</em> &lt; 0.001, respectively). The oral administration of GABA/<span class="small-caps">l</span>-theanine mixture improved sleep time and quality, as compared to GABA or <span class="small-caps">l</span>-theanine alone.</p>
<div id="F0003" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078698706080">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p><img loading="lazy" decoding="async" class="size-full wp-image-4629 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0003_B.jpg" alt="" width="680" height="771" srcset="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0003_B.jpg 680w, https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0003_B-265x300.jpg 265w" sizes="(max-width: 680px) 100vw, 680px" /></p>
</div>
<div id="lgnd_F0003" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3.</a></div>
<div class="caption">
<p id="p-23">Effects of the GABA, <span class="small-caps">l</span>-theanine, and GABA/<span class="small-caps">l</span>-theanine mixture on sleep quantity and quality. Values are presented as the means ± standard error (SE) for each group, <em>n</em> = 8. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among samples by Tukey’s multiple range test. Symbols indicate significant differences at ***<em>p</em> &lt; 0.001, **<em>p</em> &lt; 0.01, *<em>p</em> &lt; 0.05 by Bonferroni test. NS: not significant.</p>
</div>
</div>
</div>
<p id="p-24" class="p p-last">The θ wave was significantly increased after GABA (1.8 h) or <span class="small-caps">l</span>-theanine (2.2 h) single infusion, as well as after GABA/<span class="small-caps">l</span>-theanine combined administration (2.5 h) (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(E)</a>). The δ wave showed a tendency to decrease when GABA or <span class="small-caps">l</span>-theanine was separately administered and after GABA/<span class="small-caps">l</span>-theanine, but there were no significant differences between groups (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3(F)</a>).</p>
</div>
<div id="s0013" class="sec">
<h3 id="s0013title">Effects of GABA and <span class="small-caps">l</span>-theanine combination on sleep architecture during three sleep periods</h3>
<p id="p-25" class="p p-first"><a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4</a> depicts the sleep pattern measured for 9 days divided into 3 periods. Total sleep time increased and awakening time decreased from 1st to 3rd period in all sample groups (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4(A,B)</a>). NREM sleep was significantly increased in the GABA/<span class="small-caps">l</span>-theanine mixture group, as compared to controls during all three periods (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4(C)</a>; 1st period: <em>p</em> &lt; 0.05, 2nd period: <em>p</em> &lt; 0.05, 3rd period: <em>p</em> &lt; 0.001). REM sleep was significantly increased at all periods compared to control levels in the GABA or <span class="small-caps">l</span>-theanine alone groups, as well as the GABA/<span class="small-caps">l</span>-theanine mixture group (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4(D)</a>).</p>
<div id="F0004" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078689938256">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p><img loading="lazy" decoding="async" class="wp-image-4632 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0004_B.jpg" alt="" width="378" height="452" srcset="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0004_B.jpg 746w, https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0004_B-251x300.jpg 251w" sizes="(max-width: 378px) 100vw, 378px" /></p>
</div>
<div id="lgnd_F0004" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4.</a></div>
<div class="caption">
<p id="p-26">Effects of GABA, <span class="small-caps">l</span><strong>&#8211;</strong>theanine, and GABA/<span class="small-caps">l</span>-theanine mixture on sleep quantity and quality during administration periods. Values are presented as the means ± standard error (SE) for each group, <em>n</em> = 8. Symbols indicate significant differences by Bonferroni test, as ***<em>p</em> &lt; 0.001, **<em>p</em> &lt; 0.01, *<em>p</em> &lt; 0.05.</p>
</div>
</div>
</div>
<p id="p-27" class="p p-last">NREM sleep consists of <em>θ</em> and <em>δ</em> waves, with 4.0–8.0 and 0.5–4.0 Hz bandwidths, respectively. The use of <span class="small-caps">l</span>-theanine alone and GABA/<span class="small-caps">l</span>-theanine mixture increased <em>θ</em> waves over the ones detected in the control group during all periods. Single <span class="small-caps">l</span>-theanine administration led to a significant decrease in <em>δ</em> waves during the 1st period (2.0 h) (<em>p</em> &lt; 0.01), which gradually increased in the 3rd period (3.1 h). When GABA/<span class="small-caps">l</span>-theanine mixture was administered, <em>δ</em> wave oscillations also gradually increased from 1st (2.2 h) to 3rd period (2.7 h) (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4(E,F)</a>). In conclusion, the combined treatment with GABA and <span class="small-caps">l</span>-theanine led to a significant increase in sleep time (22.4%), especially NREM (28.8%), when administered over a long period. In addition, the use of GABA/<span class="small-caps">l</span>-theanine mixture increased θ wave and decreased δ wave oscillations in NREM sleep, when compared to the control group. Nevertheless, δ waves gradually increased with long-term administration. Therefore, the longer the administration of GABA/<span class="small-caps">l</span>-theanine mixture the better the sleep quality and the longer the sleep duration, induced.</p>
</div>
<div id="s0014" class="sec">
<h3 id="s0014title">EEG acquisition and analysis in a caffeine-induced wakefulness model</h3>
<p id="p-28" class="p p-first">EEG was performed to assess the sleep-inducing effects of GABA, <span class="small-caps">l</span>-theanine or the combination of both (GABA/<span class="small-caps">l</span>-theanine mixture) in a caffeine-induced awakening animal model (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5</a>). A significant difference (<em>p</em> &lt; 0.001) in sleeping and awakening times were observed between the arousal group, which was orally administered 10 mg/kg of caffeine and the control group which was orally administered with saline (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5(A,B)</a>). Administration of GABA, <span class="small-caps">l</span>-theanine, or the combination of both, in the caffeine-induced awakening model led to significant differences in sleep and awakening times, when compared to the arousal group (<em>p</em> &lt; 0.001). In the wakefulness model, the use of <span class="small-caps">l</span>-theanine alone or GABA/<span class="small-caps">l</span>-theanine mixture restored NREM sleep time to the control group level (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5(C)</a>). However, the use of GABA/<span class="small-caps">l</span>-theanine mixture in the wakefulness model had a tendency to restore REM sleep time, but there was no significant difference to arousal group. The administration of GABA/<span class="small-caps">l</span>-theanine mixture increased <em>θ</em> wave (1.9 h) and increased <em>δ</em> wave (2.0 h) oscillations in NREM sleep, when compared to the arousal group (1.4 and 2.5 h, respectively) (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5(E,F)</a>, <em>p</em> &lt; 0.01). These results suggest that the combined use of GABA and <span class="small-caps">l</span>-theanine rather than GABA or <span class="small-caps">l</span>-theanine alone restores sleep time and quality to normal levels, in the arousal animal model.</p>
<div id="F0005" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078695600864">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p><img loading="lazy" decoding="async" class="wp-image-4628 alignleft" src="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0005_B.jpg" alt="" width="414" height="491" srcset="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0005_B.jpg 681w, https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0005_B-253x300.jpg 253w" sizes="(max-width: 414px) 100vw, 414px" /></p>
</div>
<div id="lgnd_F0005" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5.</a></div>
<div class="caption">
<p id="p-29">Effects of the GABA, <span class="small-caps">l</span>-theanine, and GABA/<span class="small-caps">l</span>-theanine mixture on caffeine-induced wakefulness in rats at a dosage of caffeine (10 mg/kg). Values are presented as the means ± standard error (SE) for each group, <em>n</em> = 8. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among samples by Tukey’s multiple range test. Symbols indicate significant differences by Bonferroni test, as ***<em>p</em> &lt; 0.001, **<em>p</em> &lt; 0.01 compared with arousal group.</p>
</div>
</div>
</div>
</div>
<div id="s0015" class="sec sec-last">
<h3 id="s0015title">Effects of GABA and <span class="small-caps">l</span>-theanine combination on the mRNA levels of neurotransmitter receptors</h3>
<p id="p-30" class="p p-first">To investigate whether the sleep-promoting mechanism of GABA/<span class="small-caps">l</span>-theanine mixture mediates neurotransmitter receptor expression changes, the mRNA levels of GABA and glutamate receptors were evaluated (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6</a>). Transcript levels for the GABA<sub>A</sub> receptor following the combined administration of GABA/<span class="small-caps">l</span>-theanine were 1.53-fold higher than control levels (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6(A)</a>, <em>p</em> &lt; 0.01). Moreover, GABA/<span class="small-caps">l</span>-theanine combined infusion led to significant changes in the mRNA levels of GABA<sub>B</sub>-R2 (21.4%), as compared to controls (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6(C)</a>, <em>p</em> &lt; 0.001). However, there was no significant difference in the mRNA levels of GABA<sub>B</sub>-R1 compared to the control group (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6(B)</a>).</p>
<div id="F0006" class="fig iconblock whole_rhythm">
<div class="figure" data-largeobj="" data-largeobj-link-rid="largeobj_idm140078693184592">
<div class="ts_bar small" title="Click on image to zoom"></div>
<p><img loading="lazy" decoding="async" class="wp-image-4633 alignright" src="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0006_B-1.jpg" alt="" width="560" height="289" srcset="https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0006_B-1.jpg 690w, https://goodshepherdmedia.net/wp-content/uploads/2022/12/IPHB_A_1557698_F0006_B-1-300x155.jpg 300w" sizes="(max-width: 560px) 100vw, 560px" /></p>
</div>
<div id="lgnd_F0006" class="icnblk_cntnt">
<div><a class="figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6.</a></div>
<div class="caption">
<p id="p-31">Effects of the GABA/<span class="small-caps">l</span>-theanine mixture on GABA and glutamate receptors mRNA expression in the mouse brain. Values are presented as mean ± standard error of the mean (SEM) for the brain regions of 8 mice and for each group, <em>n</em> = 8. Different letters indicate significant differences (<em>p</em> &lt; 0.05) among samples by Tukey’s multiple range test. Symbols indicate significant differences by Bonferroni test, as ***<em>p</em> &lt; 0.001, **<em>p</em> &lt; 0.01, *<em>p</em> &lt; 0.05. NS: not significant.</p>
</div>
</div>
</div>
<p id="p-32" class="p p-last">GABA/<span class="small-caps">l</span>-theanine mixture significantly increased the mRNA levels of the GluN1 glutamate receptor subunit, as compared to control (13.8%) (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6(E)</a>, <em>p</em> &lt; 0.05). However, administration of <span class="small-caps">l</span>-theanine alone also altered the GluR1 glutamate receptor (12.5%) and GluN1 glutamate subunit (7.2%) expressions when compared to controls (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6(D,E)</a>, <em>p</em> &lt; 0.05). These results indicate that increased expression of GABA receptors GABA<sub>A</sub>, GABA<sub>B</sub>-R1 and GABA<sub>B</sub>-R2, and the GluN1 glutamate receptor subunit observed with GABA/<span class="small-caps">l</span>-theanine, may possibly lead to improved sleep behaviour and neurological regulation.</p>
</div>
</div>
<h1 class="heading-title">Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models</h1>
<h2 class="title">Abstract</h2>
<div id="eng-abstract" class="abstract-content selected">
<p>The aim of this study was to investigate the sleep-promoting effect of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality and quantity in vertebrate models. Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of two amino acids and GABA/5-HTP mixture. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. The GABA/5-HTP mixture significantly regulated the sleep latency, duration (p&lt;0.005), and also increased the sleep quality than single administration of the amino acids (p&lt;0.000). Long-term administration increased the transcript levels of GABAA receptor (1.37-fold, p&lt;0.000) and also increased the GABA content compared with the control group 12h after administration (1.43-fold, p&lt;0.000). Our available evidence suggests that the GABA/5-HTP mixture modulates both GABAergic and serotonergic signaling. Moreover, the sleep architecture can be controlled by the regulation of GABAA receptor and GABA content with 5-HTP.</p>
</div>
<p><strong class="sub-title">Keywords: </strong>5-Hydroxytryptophan; Electroencephalogram; Pentobarbital; Sleep; Vertebrate; γ-Aminobutyric acid.</p>
<hr />
<h1 class="heading-title">The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent</h1>
<h2 class="title">Abstract</h2>
<div id="eng-abstract" class="abstract-content selected">
<p>L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.</p>
<hr />
</div>
<h1 class="heading-title">A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality <i>via</i> Regulating Brain Electrochemical Activity</h1>
<hr />
<div id="s0016" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="s0016title" class="head no_bottom_margin ui-helper-clearfix">Discussion</h2>
<p id="p-33" class="p p-first">The pentobarbital-induced sleeping model was used to identify the optimal sleep enhancement dosing ratio for GABA and <span class="small-caps">l</span>-theanine. In this study, the combination of GABA and <span class="small-caps">l</span>-theanine (100/20 mg/kg) not only did it reduce sleep latency but also prolonged sleep duration in pentobarbital-induced sleep model. The key finding of this study is the confirmation of the synergistic action (<em>p</em> &lt; 0.01, compared to control) of GABA and <span class="small-caps">l</span>-theanine on sleep behaviour, which significantly decreased sleep latency and increased sleep duration.</p>
<p id="p-34">Amino acid neurotransmitters are important for the function of the central nervous system (CNS). They are fast-acting, inducing responses within milliseconds and play an important role in physiological brain function and neurological diseases (Krystal et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0024" aria-expanded="false" aria-haspopup="true">2002</a>). Rapid neurotransmitter regulation and nerve function, facilitation of relaxation without drowsiness, stress relief (including physical stress), and <span class="small-caps">l</span>-theanine-mediated excitement are known strategies used for the improvement of sleep quality and for exhaustion recovery (Rao et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0033" aria-expanded="false" aria-haspopup="true">2015</a>).</p>
<p id="p-35">Sleep deprivation is known to cause serious illnesses such as cardiovascular disease, diabetes, and cancer (Davis and Mirick <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0006" aria-expanded="false" aria-haspopup="true">2006</a>; Laposky et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0025" aria-expanded="false" aria-haspopup="true">2008</a>; Baron and Reid <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0002" aria-expanded="false" aria-haspopup="true">2014</a>). The pentobarbital-induced sleep test and the EEG measurement that have been performed usually in a study of sleep enhancement were used to confirm the synergy effect of GABA/<span class="small-caps">l</span>-theanine mixture in sleep enhancement (Jeon et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0013" aria-expanded="false" aria-haspopup="true">2015</a>).</p>
<p id="p-36">The combination of GABA and <span class="small-caps">l</span>-theanine (80/20 and 100/30 mg/kg) did not show a synergistic effect in sleep latency and sleep duration unlike the GABA/<span class="small-caps">l</span>-theanine mixture (100/20 mg/kg). Lin et al. (<a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0027" aria-expanded="false" aria-haspopup="true">2010</a>) reported that the synergistic effects were different depending on the ratio of taurine and caffeine, and it is important to identify specific synergistic ratio in the study of combined sample administration. However, further research is needed to determine that synergistic effects are achieved only at a specific ratio with any pharmacokinetic mechanism.</p>
<p id="p-37">GABA acts through GABA receptors. There are generally 2 types of GABA receptors: GABA<sub>A</sub> and GABA<sub>B</sub>. The most important receptor, with respect to sleep is the GABA<sub>A</sub> receptor (Gottesmann <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0009" aria-expanded="false" aria-haspopup="true">2002</a>). When GABA or another agonist binds to GABA<sub>A</sub> receptor, it triggers the influx of chloride ions in neuronal cells. This causes a negative membrane potential that inhibits action potential firing. In this way, GABA (and GABA-promoting compounds) reduce activity in brain cells through GABA<sub>A</sub> receptor activation. It is well-known that the activation of GABA<sub>A</sub> receptors is beneficial for sleep (Abdou et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0001" aria-expanded="false" aria-haspopup="true">2006</a>). The structural similarity of <span class="small-caps">l</span>-theanine to the neurotransmitter glutamic acid has prompted researchers to study its potential competition binding on glutamate receptors in the nervous system (Shinozaki and Ishida <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0035" aria-expanded="false" aria-haspopup="true">1978</a>). <span class="small-caps">l</span>-Theanine rapidly induces changes in serotonergic and dopaminergic transmission (Yokogoshi et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0044" aria-expanded="false" aria-haspopup="true">1998</a>). These components act as modulating receptors of the neurotransmitter GABA, which is the main inhibitory neurotransmitter in the CNS, and therefore, one of the main molecules responsible for sleeping behaviour (Zanoli and Zavatti <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0045" aria-expanded="false" aria-haspopup="true">2008</a>). The decreases in sleep latency, together with a slight improvement in sleep quality, are the possible reasons for the observed increase in sleep efficiency, in our study.</p>
<p id="p-38">As characterized by EEG recordings, sleep is broadly divided into REM and NREM (Bersagliere et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0003" aria-expanded="false" aria-haspopup="true">2018</a>). Combined oral administration of GABA and <span class="small-caps">l</span>-theanine significantly increased the amount of NREM sleep, as compared to controls (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3</a>, <em>p</em> &lt; 0.05), via an increase in theta waves. Moreover, awake time was also significantly decreased following GABA/<span class="small-caps">l</span>-theanine administration, as compared to all other groups (<em>p</em> &lt; 0.001, <a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0003/" target="figure" rel="noopener">Figure 3</a>). Brain waves can be classified into four types: <em>α</em> (less than 8<strong>–</strong>13 Hz), <em>β</em> (more than 13 Hz), <em>θ</em> (less than 4<strong>–</strong>8 Hz), and <em>δ</em> waves (less than 4 Hz) (Abdou et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0001" aria-expanded="false" aria-haspopup="true">2006</a>). Each wave type is associated with a specific mental state. Delta and theta occur in the early stages of deep sleep and sleep, respectively (Ray and Cole <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0034" aria-expanded="false" aria-haspopup="true">1985</a>).</p>
<p id="p-39">We observed a tendency for NREM sleep to increase with increasing dosing periods during the combined oral administration of GABA and <span class="small-caps">l</span>-theanine, probably due to <span class="small-caps">l</span>-theanine (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0004/" target="figure" rel="noopener">Figure 4</a>). This change in NREM is likely due to changes in delta waves after GABA/<span class="small-caps">l</span>-theanine administration. EEG frequency estimation revealed increased delta and decreased beta activity in the NREM state. Caffeine causes a variety of sleep disturbances, including total sleep time reduction, prolonged sleep onset latency and increased arousal in humans and rats through adenosine receptor blockade (Deckert and Gleiter <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0007" aria-expanded="false" aria-haspopup="true">1989</a>).</p>
<p id="p-40">In <a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5</a>, caffeine decreased sleep time, especially NREM and increased the awake time in rats. The results indicate that GABA and <span class="small-caps">l</span>-theanine combined intake can reverse caffeine-induced sleep reduction, especially NREM, in rats (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0005/" target="figure" rel="noopener">Figure 5</a>). Administration of <span class="small-caps">l</span>-theanine has been reported to inhibit caffeine’s convulsive action and to increase GABA brain levels in mice (Kimuraand Murata 1971). <span class="small-caps">l</span>-Theanine is known to decrease norepinephrine levels in the rat brain and suppress caffeine-induced serotonin and 5-hydroxyindoleacetic acid increases in rats (Kimura and Murata <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0023" aria-expanded="false" aria-haspopup="true">1986</a>). Furthermore, the neuroprotective effect of theanine has been shown to be mediated via glutamate receptors, as theanine acts as a glutamate receptor antagonist (Kakuda et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0017" aria-expanded="false" aria-haspopup="true">2000</a>). The above results suggested that the GABA/<span class="small-caps">l</span>-theanine mixture was significantly superior to GABA or <span class="small-caps">l</span>-theanine alone, for reducing sleep latency, awake time and extending NREM sleep duration. The <span class="small-caps">l</span>-theanine seems to play a major role in the synergistic effect of GABA and <span class="small-caps">l</span>-theanine combination. A trend for prolonged NREM with increasing <span class="small-caps">l</span>-theanine dosing was observed, which was similar to the delta wave increasing trend. In the caffeine-induced arousal model, combined GABA and <span class="small-caps">l</span>-theanine led to a similar synergistic effect on sleep enhancement. The combination of GABA and <span class="small-caps">l</span>-theanine is an attractive NREM sleep-promoting regimen as it increases delta wave oscillations.</p>
<p id="p-41">As shown in <a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6</a>, GABA<sub>A</sub> receptor expression levels were significantly changed in mice with administration GABA<strong>/</strong><span class="small-caps">l</span>-theanine mixture compared with the control group (<em>p</em> &lt; 0.01). The GABA<sub>A</sub> receptor complex is a chloride ionophore, which consists primarily of GABA, barbiturate, benzodiazepine, steroid and picrotoxin binding sites (MacDonald and Olsen <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0029" aria-expanded="false" aria-haspopup="true">1994</a>). Parisky et al. (<a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0032" aria-expanded="false" aria-haspopup="true">2008</a>) demonstrated that GABA<sub>A</sub> receptor over expression increases total sleep time, while down-regulation of the receptor decreases sleep duration. The metabotropic GABA<sub>B</sub> receptor can influence the activation of Ca<sup>+2</sup> and K<sup>+</sup> ion channels via G-protein coupled second messengers. The affinity of GABA to GABA<sub>B</sub> receptors is lower than that for GABA<sub>A</sub> receptors (Chu et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0004" aria-expanded="false" aria-haspopup="true">1990</a>). The sedative or sleep-inducing effect of GABA is most likely mediated via GABA receptors. GABA receptor expression in the rat brain was significantly increased following the combined administration of GABA and <span class="small-caps">l</span>-theanine but not after GABA infusion alone. <span class="small-caps">l</span>-Theanine has a similar chemical structure to glutamate and <span class="small-caps">l</span>-theanine has micromolar affinities for kainate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and N-methyl-<sub>D</sub>-aspartate (NMDA) glutamate receptors (Kakuda et al. <a class=" bibr popnode" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#CIT0016" aria-expanded="false" aria-haspopup="true">2002</a>). <span class="small-caps">l</span>-Theanine can act as a competitive glutamate antagonist. The mRNA level of the NDMA receptor subunit GluN1 was slightly higher following GABA/<span class="small-caps">l</span>-theanine infusion than after <span class="small-caps">l</span>-theanine treatment alone (<a class="fig-table-link figpopup" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/figure/F0006/" target="figure" rel="noopener">Figure 6</a>).</p>
<p id="p-42" class="p p-last">In conclusion, our results demonstrate that the combined use of GABA and <span class="small-caps">l</span>-theanine increase sleep activity to more than a single administration of either amino acid or these synergistic sleep-promoting effects are likely mediated via changes in GABA and/or glutamate receptor expression in the brain. In summary, this result suggests that GABA/<span class="small-caps">l</span>-theanine mixture could be used for treatment for insomnia and sleep disorders as a concept of nonpharmacological management of sleep.</p>
</div>
<div id="funding-group-1" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="funding-group-1title" class="head no_bottom_margin ui-helper-clearfix">Funding Statement</h2>
<p>This research was supported by the Ministry of Trade, Industry &amp; Energy (MOTIE), Korea Institute for Advancement of Technology (KIAT) through the Encouragement Program for The Industries of Economic Cooperation Region (R0004012).</p>
</div>
<div id="s0017" class="tsec bk-sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="s0017title" class="head no_bottom_margin ui-helper-clearfix">Disclosure statement</h2>
<p id="p-43" class="p p-first-last">No potential conflict of interest was reported by the authors.</p>
</div>
<div id="ref-list-1" class="tsec sec">
<div class="goto jig-ncbiinpagenav-goto-container"><a class="tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading" title="Go to other sections in this page" role="button" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/#" aria-expanded="false" aria-haspopup="true">Go to:</a></div>
<h2 id="ref-list-1title" class="head no_bottom_margin ui-helper-clearfix">References</h2>
<div id="reference-list" class="ref-list-sec sec">
<ol class="back-ref-list">
<li id="CIT0001"><span class="mixed-citation">Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. 2006. <span class="ref-title">Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans</span>. <span class="ref-journal">Biofactors</span>. <span class="ref-vol">26</span>:201–208. [<a href="https://pubmed.ncbi.nlm.nih.gov/16971751">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Biofactors&amp;title=Relaxation+and+immunity+enhancement+effects+of+gamma-aminobutyric+acid+(GABA)+administration+in+humans&amp;author=AM+Abdou&amp;author=S+Higashiguchi&amp;author=K+Horie&amp;author=M+Kim&amp;author=H+Hatta&amp;volume=26&amp;publication_year=2006&amp;pages=201-208&amp;pmid=16971751&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0002"><span class="mixed-citation">Baron KG, Reid KJ. 2014. <span class="ref-title">Circadian misalignment and health</span>. <span class="ref-journal">Int Rev Psychiatry</span>. <span class="ref-vol">26</span>:139–154. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677771/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24892891">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Int+Rev+Psychiatry&amp;title=Circadian+misalignment+and+health&amp;author=KG+Baron&amp;author=KJ+Reid&amp;volume=26&amp;publication_year=2014&amp;pages=139-154&amp;pmid=24892891&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0003"><span class="mixed-citation">Bersagliere A, Pascual-Marqui RD, Tarokh L, Achermann P. 2018. <span class="ref-title">Mapping slow waves by EEG topography and source localization: effects of sleep deprivation</span>. <span class="ref-journal">Brain Topogr</span>. <span class="ref-vol">31</span>:257–269. [<a href="https://pubmed.ncbi.nlm.nih.gov/28983703">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Brain+Topogr&amp;title=Mapping+slow+waves+by+EEG+topography+and+source+localization:+effects+of+sleep+deprivation&amp;author=A+Bersagliere&amp;author=RD+Pascual-Marqui&amp;author=L+Tarokh&amp;author=P+Achermann&amp;volume=31&amp;publication_year=2018&amp;pages=257-269&amp;pmid=28983703&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0004"><span class="mixed-citation">Chu D, Albin RL, Young AB, Penney JB. 1990. <span class="ref-title">Distribution and kinetics of GABA<sub>B</sub> binding sites in rat central nervous system: a quantitative autoradiographic study</span>. <span class="ref-journal">Neuroscience</span>. <span class="ref-vol">34</span>:341–357. [<a href="https://pubmed.ncbi.nlm.nih.gov/2159128">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Neuroscience&amp;title=Distribution+and+kinetics+of+GABAB+binding+sites+in+rat+central+nervous+system:+a+quantitative+autoradiographic+study&amp;author=D+Chu&amp;author=RL+Albin&amp;author=AB+Young&amp;author=JB+Penney&amp;volume=34&amp;publication_year=1990&amp;pages=341-357&amp;pmid=2159128&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0005"><span class="mixed-citation">Coda R, Rizzello CG, Gobbetti M. 2010. <span class="ref-title">Use of sourdough fermentation and pseudo-cereals and leguminous flours for the making of a functional bread enriched of gamma-aminobutyric acid (GABA)</span>. <span class="ref-journal">Int J Food Microbiol</span>. <span class="ref-vol">137</span>:236–245. [<a href="https://pubmed.ncbi.nlm.nih.gov/20071045">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Int+J+Food+Microbiol&amp;title=Use+of+sourdough+fermentation+and+pseudo-cereals+and+leguminous+flours+for+the+making+of+a+functional+bread+enriched+of+gamma-aminobutyric+acid+(GABA)&amp;author=R+Coda&amp;author=CG+Rizzello&amp;author=M+Gobbetti&amp;volume=137&amp;publication_year=2010&amp;pages=236-245&amp;pmid=20071045&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0006"><span class="mixed-citation">Davis S, Mirick DK. 2006. <span class="ref-title">Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle</span>. <span class="ref-journal">Cancer Causes Control</span>. <span class="ref-vol">17</span>:539–545. [<a href="https://pubmed.ncbi.nlm.nih.gov/16596308">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Cancer+Causes+Control&amp;title=Circadian+disruption,+shift+work+and+the+risk+of+cancer:+a+summary+of+the+evidence+and+studies+in+Seattle&amp;author=S+Davis&amp;author=DK+Mirick&amp;volume=17&amp;publication_year=2006&amp;pages=539-545&amp;pmid=16596308&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0007"><span class="mixed-citation">Deckert J, Gleiter CH. 1989. <span class="ref-title">Adenosinergic psychopharmaceuticals? </span><span class="ref-journal">Trends Pharmacol Sci</span>. <span class="ref-vol">10</span>:99–100. [<a href="https://pubmed.ncbi.nlm.nih.gov/2595795">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Trends+Pharmacol+Sci&amp;title=Adenosinergic+psychopharmaceuticals?&amp;author=J+Deckert&amp;author=CH+Gleiter&amp;volume=10&amp;publication_year=1989&amp;pages=99-100&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0008"><span class="mixed-citation">Dhakal R, Bajpai VK, Baek KH. 2012. <span class="ref-title">Production of GABA (γ-Aminobutyric acid) by microorganisms: a review</span>. <span class="ref-journal">Braz J Microbiol</span>. <span class="ref-vol">43</span>:1230–1241. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769009/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24031948">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Braz+J+Microbiol&amp;title=Production+of+GABA+(%CE%B3-Aminobutyric+acid)+by+microorganisms:+a+review&amp;author=R+Dhakal&amp;author=VK+Bajpai&amp;author=KH+Baek&amp;volume=43&amp;publication_year=2012&amp;pages=1230-1241&amp;pmid=24031948&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0009"><span class="mixed-citation">Gottesmann C. 2002. <span class="ref-title">GABA mechanisms and sleep</span>. <span class="ref-journal">Neuroscience</span>. <span class="ref-vol">111</span>:231–239. [<a href="https://pubmed.ncbi.nlm.nih.gov/11983310">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Neuroscience&amp;title=GABA+mechanisms+and+sleep&amp;author=C+Gottesmann&amp;volume=111&amp;publication_year=2002&amp;pages=231-239&amp;pmid=11983310&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0010"><span class="mixed-citation">Graham HN. 1992. <span class="ref-title">Green tea composition, consumption, and polyphenol chemistry</span>. <span class="ref-journal">Prev Med</span>. <span class="ref-vol">21</span>:334–350. [<a href="https://pubmed.ncbi.nlm.nih.gov/1614995">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Prev+Med&amp;title=Green+tea+composition,+consumption,+and+polyphenol+chemistry&amp;author=HN+Graham&amp;volume=21&amp;publication_year=1992&amp;pages=334-350&amp;pmid=1614995&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0011"><span class="mixed-citation">Hong KB, Park Y, Suh HJ. 2016. <span class="ref-title">Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models</span>. <span class="ref-journal">Behav Brain Res</span>. <span class="ref-vol">310</span>:36–41. [<a href="https://pubmed.ncbi.nlm.nih.gov/27150227">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Behav+Brain+Res&amp;title=Sleep-promoting+effects+of+the+GABA/5-HTP+mixture+in+vertebrate+models&amp;author=KB+Hong&amp;author=Y+Park&amp;author=HJ+Suh&amp;volume=310&amp;publication_year=2016&amp;pages=36-41&amp;pmid=27150227&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0012"><span class="mixed-citation">Jang HS, Jung JY, Jang IS, Jang KH, Kim SH, Ha JH, Suk K, Lee MG. 2012. <span class="ref-title">l-Theanine partially counteracts caffeine-induced sleep disturbances in rats</span>. <span class="ref-journal">Pharmacol Biochem Behav</span>. <span class="ref-vol">101</span>:217–221. [<a href="https://pubmed.ncbi.nlm.nih.gov/22285321">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Pharmacol+Biochem+Behav&amp;title=l-Theanine+partially+counteracts+caffeine-induced+sleep+disturbances+in+rats&amp;author=HS+Jang&amp;author=JY+Jung&amp;author=IS+Jang&amp;author=KH+Jang&amp;author=SH+Kim&amp;volume=101&amp;publication_year=2012&amp;pages=217-221&amp;pmid=22285321&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0013"><span class="mixed-citation">Jeon SJ, Park HJ, Gao Q, dela Pena IJ, Park SJ, Lee HE, Woo H, Kim HJ, Cheong JH, Hong EY, et al.. 2015. <span class="ref-title">Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice</span>. <span class="ref-journal">Eur J Pharmacol</span>. <span class="ref-vol">762</span>:443–448. [<a href="https://pubmed.ncbi.nlm.nih.gov/26102564">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Eur+J+Pharmacol&amp;title=Ursolic+acid+enhances+pentobarbital-induced+sleeping+behaviors+via+GABAergic+neurotransmission+in+mice&amp;author=SJ+Jeon&amp;author=HJ+Park&amp;author=Q+Gao&amp;author=IJ+dela+Pena&amp;author=SJ+Park&amp;volume=762&amp;publication_year=2015&amp;pages=443-448&amp;pmid=26102564&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0014"><span class="mixed-citation">Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H. 1999. <span class="ref-title">l-Theanine-a unique amino acid of green tea and its relaxation effect in humans</span>. <span class="ref-journal">Trends Food Sci Technol</span>. <span class="ref-vol">10</span>:199–204. <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Trends+Food+Sci+Technol&amp;title=l-Theanine-a+unique+amino+acid+of+green+tea+and+its+relaxation+effect+in+humans&amp;author=LR+Juneja&amp;author=DC+Chu&amp;author=T+Okubo&amp;author=Y+Nagato&amp;author=H+Yokogoshi&amp;volume=10&amp;publication_year=1999&amp;pages=199-204&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0015"><span class="mixed-citation">Kakuda T. 2011. <span class="ref-title">Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction</span>. <span class="ref-journal">Pharmacol Res</span>. <span class="ref-vol">64</span>:162–168. [<a href="https://pubmed.ncbi.nlm.nih.gov/21477654">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Pharmacol+Res&amp;title=Neuroprotective+effects+of+theanine+and+its+preventive+effects+on+cognitive+dysfunction&amp;author=T+Kakuda&amp;volume=64&amp;publication_year=2011&amp;pages=162-168&amp;pmid=21477654&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0016"><span class="mixed-citation">Kakuda T, Nozawa A, Sugimoto A, Niino H. 2002. <span class="ref-title">Inhibition by theanine of binding of [<sup>3</sup>H]AMPA, [<sup>3</sup>H]kainate, and [<sup>3</sup>H]MDL 105,519 to glutamate receptors</span> . <span class="ref-journal">Biosci Biotechnol Biochem</span>. <span class="ref-vol">66</span>:2683–2686. [<a href="https://pubmed.ncbi.nlm.nih.gov/12596867">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Biosci+Biotechnol+Biochem&amp;title=Inhibition+by+theanine+of+binding+of+[3H]AMPA,+[3H]kainate,+and+[3H]MDL+105,519+to+glutamate+receptors&amp;author=T+Kakuda&amp;author=A+Nozawa&amp;author=A+Sugimoto&amp;author=H+Niino&amp;volume=66&amp;publication_year=2002&amp;pages=2683-2686&amp;pmid=12596867&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0017"><span class="mixed-citation">Kakuda T, Yanase H, Utsunomiya K, Nozawa A, Unno T, Kataoka K. 2000. <span class="ref-title">Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils</span>. <span class="ref-journal">Neurosci Lett</span>. <span class="ref-vol">289</span>:189–192. [<a href="https://pubmed.ncbi.nlm.nih.gov/10961661">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Neurosci+Lett&amp;title=Protective+effect+of+gamma-glutamylethylamide+(theanine)+on+ischemic+delayed+neuronal+death+in+gerbils&amp;author=T+Kakuda&amp;author=H+Yanase&amp;author=K+Utsunomiya&amp;author=A+Nozawa&amp;author=T+Unno&amp;volume=289&amp;publication_year=2000&amp;pages=189-192&amp;pmid=10961661&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0018"><span class="mixed-citation">Khan S, Duan P, Yao L, Hou H. 2018. <span class="ref-title">Shiftwork-mediated disruptions of circadian rhythms and sleep homeostasis cause serious health problems</span>. <span class="ref-journal">Int J Genomics</span>. <span class="ref-vol">2018</span>:1–11. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828540/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/29607311">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Int+J+Genomics&amp;title=Shiftwork-mediated+disruptions+of+circadian+rhythms+and+sleep+homeostasis+cause+serious+health+problems&amp;author=S+Khan&amp;author=P+Duan&amp;author=L+Yao&amp;author=H+Hou&amp;volume=2018&amp;publication_year=2018&amp;pages=1-11&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0019"><span class="mixed-citation">Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. 2007. <span class="ref-title">Valerenic acid potentiates and inhibits GABA<sub>A</sub> receptors: molecular mechanism and subunit specificity</span>. <span class="ref-journal">Neuropharmacology</span>. <span class="ref-vol">53</span>:178–187. [<a href="https://pubmed.ncbi.nlm.nih.gov/17585957">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Neuropharmacology&amp;title=Valerenic+acid+potentiates+and+inhibits+GABAA+receptors:+molecular+mechanism+and+subunit+specificity&amp;author=S+Khom&amp;author=I+Baburin&amp;author=E+Timin&amp;author=A+Hohaus&amp;author=G+Trauner&amp;volume=53&amp;publication_year=2007&amp;pages=178-187&amp;pmid=17585957&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0020"><span class="mixed-citation">Kim TI, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam S-Y, Yun YW, Han SB, Oh KW, et al.. 2009. <span class="ref-title">l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways</span>. <span class="ref-journal">Free Radic Biol Med</span>. <span class="ref-vol">47</span>:1601–1610. [<a href="https://pubmed.ncbi.nlm.nih.gov/19766184">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Free+Radic+Biol+Med&amp;title=l-Theanine,+an+amino+acid+in+green+tea,+attenuates+beta-amyloid-induced+cognitive+dysfunction+and+neurotoxicity:+reduction+in+oxidative+damage+and+inactivation+of+ERK/p38+kinase+and+NF-kappaB+pathways&amp;author=TI+Kim&amp;author=YK+Lee&amp;author=SG+Park&amp;author=IS+Choi&amp;author=JO+Ban&amp;volume=47&amp;publication_year=2009&amp;pages=1601-1610&amp;pmid=19766184&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0021"><span class="mixed-citation">Kimura K, Ozeki M, Juneja LR, Ohira H. 2007. <span class="ref-title">l-Theanine reduces psychological and physiological stress responses</span>. <span class="ref-journal">Biol Psychol</span>. <span class="ref-vol">74</span>:39–45. [<a href="https://pubmed.ncbi.nlm.nih.gov/16930802">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Biol+Psychol&amp;title=l-Theanine+reduces+psychological+and+physiological+stress+responses&amp;author=K+Kimura&amp;author=M+Ozeki&amp;author=LR+Juneja&amp;author=H+Ohira&amp;volume=74&amp;publication_year=2007&amp;pages=39-45&amp;pmid=16930802&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0022"><span class="mixed-citation">Kimura R, Murata T. 1971. <span class="ref-title">Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine</span>. <span class="ref-journal">Chem Pharm Bull</span>. <span class="ref-vol">19</span>:1257–1261. [<a href="https://pubmed.ncbi.nlm.nih.gov/4397636">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Chem+Pharm+Bull&amp;title=Influence+of+alkylamides+of+glutamic+acid+and+related+compounds+on+the+central+nervous+system.+I.+Central+depressant+effect+of+theanine&amp;author=R+Kimura&amp;author=T+Murata&amp;volume=19&amp;publication_year=1971&amp;pages=1257-1261&amp;pmid=4397636&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0023"><span class="mixed-citation">Kimura R, Murata T. 1986. <span class="ref-title">Effect of theanine on norepinephrine and serotonin levels in rat brain</span>. <span class="ref-journal">Chem Pharm Bull</span>. <span class="ref-vol">34</span>:3053–3057. [<a href="https://pubmed.ncbi.nlm.nih.gov/3769108">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Chem+Pharm+Bull&amp;title=Effect+of+theanine+on+norepinephrine+and+serotonin+levels+in+rat+brain&amp;author=R+Kimura&amp;author=T+Murata&amp;volume=34&amp;publication_year=1986&amp;pages=3053-3057&amp;pmid=3769108&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0024"><span class="mixed-citation">Krystal JH, Sanacora G, Blumberg H, Anand A, Charney D, Marek G, Epperson C, Goddard A, Mason G. 2002. <span class="ref-title">Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments</span>. <span class="ref-journal">Mol Psychiatry</span>. <span class="ref-vol">7</span>:71–80. [<a href="https://pubmed.ncbi.nlm.nih.gov/11986998">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Mol+Psychiatry&amp;title=Glutamate+and+GABA+systems+as+targets+for+novel+antidepressant+and+mood-stabilizing+treatments&amp;author=JH+Krystal&amp;author=G+Sanacora&amp;author=H+Blumberg&amp;author=A+Anand&amp;author=D+Charney&amp;volume=7&amp;publication_year=2002&amp;pages=71-80&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0025"><span class="mixed-citation">Laposky AD, Bass J, Kohsaka A, Turek FW. 2008. <span class="ref-title">Sleep and circadian rhythms: key components in the regulation of energy metabolism</span>. <span class="ref-journal">FEBS Lett</span>. <span class="ref-vol">582</span>:142–151. [<a href="https://pubmed.ncbi.nlm.nih.gov/17707819">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=FEBS+Lett&amp;title=Sleep+and+circadian+rhythms:+key+components+in+the+regulation+of+energy+metabolism&amp;author=AD+Laposky&amp;author=J+Bass&amp;author=A+Kohsaka&amp;author=FW+Turek&amp;volume=582&amp;publication_year=2008&amp;pages=142-151&amp;pmid=17707819&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0026"><span class="mixed-citation">Lichstein KL, Nau SD, Wilson NM, Aguillard RN, Lester KW, Bush AJ, McCrae CS. 2013. <span class="ref-title">Psychological treatment of hypnotic-dependent insomnia in a primarily older adult sample</span>. <span class="ref-journal">Behav Res Ther</span>. <span class="ref-vol">51</span>:787–796. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838504/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24121096">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Behav+Res+Ther&amp;title=Psychological+treatment+of+hypnotic-dependent+insomnia+in+a+primarily+older+adult+sample&amp;author=KL+Lichstein&amp;author=SD+Nau&amp;author=NM+Wilson&amp;author=RN+Aguillard&amp;author=KW+Lester&amp;volume=51&amp;publication_year=2013&amp;pages=787-796&amp;pmid=24121096&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0027"><span class="mixed-citation">Lin FJ, Pierce MM, Sehgal A, Wu T, Skipper DC, Chabba R. 2010. <span class="ref-title">Effect of taurine and caffeine on sleep-wake activity in <em>Drosophila melanogaster</em></span>. <span class="ref-journal">Nat Sci Sleep</span>. <span class="ref-vol">2</span>:221–231. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630960/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/23616711">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Nat+Sci+Sleep&amp;title=Effect+of+taurine+and+caffeine+on+sleep-wake+activity+in+Drosophila+melanogaster&amp;author=FJ+Lin&amp;author=MM+Pierce&amp;author=A+Sehgal&amp;author=T+Wu&amp;author=DC+Skipper&amp;volume=2&amp;publication_year=2010&amp;pages=221-231&amp;pmid=23616711&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0028"><span class="mixed-citation">Longo LP, Johnson B. 2000. <span class="ref-title">Addiction: part I. Benzodiazepines-side effects, abuse risk and alternatives</span>. <span class="ref-journal">Am Fam Physician</span>. <span class="ref-vol">61</span>:2121–2128. [<a href="https://pubmed.ncbi.nlm.nih.gov/10779253">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Am+Fam+Physician&amp;title=Addiction:+part+I.+Benzodiazepines-side+effects,+abuse+risk+and+alternatives&amp;author=LP+Longo&amp;author=B+Johnson&amp;volume=61&amp;publication_year=2000&amp;pages=2121-2128&amp;pmid=10779253&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0029"><span class="mixed-citation">MacDonald RL, Olsen RW. 1994. <span class="ref-title">GABA<sub>A</sub> receptor channels</span>. <span class="ref-journal">Ann Rev Neurosci</span>. <span class="ref-vol">17</span>:569–602. [<a href="https://pubmed.ncbi.nlm.nih.gov/7516126">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Ann+Rev+Neurosci&amp;title=GABAA+receptor+channels&amp;author=RL+MacDonald&amp;author=RW+Olsen&amp;volume=17&amp;publication_year=1994&amp;pages=569-602&amp;pmid=7516126&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0030"><span class="mixed-citation">Nathan PJ, Lu K, Gray M, Oliver C. 2006. <span class="ref-title">The neuropharmacology of L-theanine(<em>N</em>-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent</span>. <span class="ref-journal">J Herb Pharmacother</span>. <span class="ref-vol">6</span>:21–30. [<a href="https://pubmed.ncbi.nlm.nih.gov/17182482">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Herb+Pharmacother&amp;title=The+neuropharmacology+of+L-theanine(N-ethyl-L-glutamine):+a+possible+neuroprotective+and+cognitive+enhancing+agent&amp;author=PJ+Nathan&amp;author=K+Lu&amp;author=M+Gray&amp;author=C+Oliver&amp;volume=6&amp;publication_year=2006&amp;pages=21-30&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0031"><span class="mixed-citation">Oh SH, Oh KW, Cho HK, Eun JS. 2010. <span class="ref-title">Effects of the combined-preparation of germinated brown rice, cultured mountain ginseng and longanae arillus on pentobarbital-induced sleeping time</span>. <span class="ref-journal">J Physiol &amp; Pathol Korean Med</span>. <span class="ref-vol">24</span>:598–601. <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Physiol+&amp;+Pathol+Korean+Med&amp;title=Effects+of+the+combined-preparation+of+germinated+brown+rice,+cultured+mountain+ginseng+and+longanae+arillus+on+pentobarbital-induced+sleeping+time&amp;author=SH+Oh&amp;author=KW+Oh&amp;author=HK+Cho&amp;author=JS+Eun&amp;volume=24&amp;publication_year=2010&amp;pages=598-601&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0032"><span class="mixed-citation">Parisky KM, Agosto J, Pulver SR, Shang Y, Kuklin E, Hodge JJL, Kang K, Kang K, Liu X, Garrity PA, et al.. 2008. <span class="ref-title">PDF cells are a GABA-responsive wake-promoting component of the <em>Drosophila</em> sleep circuit</span>. <span class="ref-journal">Neuron</span>. <span class="ref-vol">60</span>:672–682. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734413/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19038223">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Neuron&amp;title=PDF+cells+are+a+GABA-responsive+wake-promoting+component+of+the+Drosophila+sleep+circuit&amp;author=KM+Parisky&amp;author=J+Agosto&amp;author=SR+Pulver&amp;author=Y+Shang&amp;author=E+Kuklin&amp;volume=60&amp;publication_year=2008&amp;pages=672-682&amp;pmid=19038223&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0033"><span class="mixed-citation">Rao TP, Ozeki M, Juneja LR. 2015. <span class="ref-title">In search of a safe natural sleep aid</span>. <span class="ref-journal">J Am Coll Nutr</span>. <span class="ref-vol">34</span>:436–447. [<a href="https://pubmed.ncbi.nlm.nih.gov/25759004">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Am+Coll+Nutr&amp;title=In+search+of+a+safe+natural+sleep+aid&amp;author=TP+Rao&amp;author=M+Ozeki&amp;author=LR+Juneja&amp;volume=34&amp;publication_year=2015&amp;pages=436-447&amp;pmid=25759004&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0034"><span class="mixed-citation">Ray WJ, Cole HW. 1985. <span class="ref-title">EEG alpha activity reflects attentional demands, and beta activity reflects emotional and cognitive processes</span>. <span class="ref-journal">Science (N.Y.)</span>. <span class="ref-vol">228</span>:750–752. [<a href="https://pubmed.ncbi.nlm.nih.gov/3992243">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Science+(N.Y.)&amp;title=EEG+alpha+activity+reflects+attentional+demands,+and+beta+activity+reflects+emotional+and+cognitive+processes&amp;author=WJ+Ray&amp;author=HW+Cole&amp;volume=228&amp;publication_year=1985&amp;pages=750-752&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0035"><span class="mixed-citation">Shinozaki H, Ishida M. 1978. <span class="ref-title">Theanine as a glutamate antagonist at a crayfish neuromuscular junction</span>. <span class="ref-journal">Brain Res</span>. <span class="ref-vol">151</span>:215–219. [<a href="https://pubmed.ncbi.nlm.nih.gov/679005">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Brain+Res&amp;title=Theanine+as+a+glutamate+antagonist+at+a+crayfish+neuromuscular+junction&amp;author=H+Shinozaki&amp;author=M+Ishida&amp;volume=151&amp;publication_year=1978&amp;pages=215-219&amp;pmid=679005&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0036"><span class="mixed-citation">Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. 2008. <span class="ref-title">Modulation of GABA<sub>A</sub> receptors by valerian extracts is related to the content of valerenic acid</span>. <span class="ref-journal">Planta Medica</span>. <span class="ref-vol">74</span>:19–24. [<a href="https://pubmed.ncbi.nlm.nih.gov/18095218">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Planta+Medica&amp;title=Modulation+of+GABAA+receptors+by+valerian+extracts+is+related+to+the+content+of+valerenic+acid&amp;author=G+Trauner&amp;author=S+Khom&amp;author=I+Baburin&amp;author=B+Benedek&amp;author=S+Hering&amp;volume=74&amp;publication_year=2008&amp;pages=19-24&amp;pmid=18095218&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0037"><span class="mixed-citation">Verdú E, Ceballos D, Vilches JJ, Navarro X. 2000. <span class="ref-title">Influence of aging on peripheral nerve function and regeneration</span>. <span class="ref-journal">J Peripher Nerv Syst</span>. <span class="ref-vol">5</span>:191–208. [<a href="https://pubmed.ncbi.nlm.nih.gov/11151980">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Peripher+Nerv+Syst&amp;title=Influence+of+aging+on+peripheral+nerve+function+and+regeneration&amp;author=E+Verd%C3%BA&amp;author=D+Ceballos&amp;author=JJ+Vilches&amp;author=X+Navarro&amp;volume=5&amp;publication_year=2000&amp;pages=191-208&amp;pmid=11151980&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0038"><span class="mixed-citation">Victorri-Vigneau C, Dailly E, Veyrac G, Jolliet P. 2007. <span class="ref-title">Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) Network survey</span>. <span class="ref-journal">Brit J Clin Pharmacol</span>. <span class="ref-vol">64</span>:198–209. <span class="nowrap">[<a class="int-reflink" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000636/">PMC free article</a>]</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17324242">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Brit+J+Clin+Pharmacol&amp;title=Evidence+of+zolpidem+abuse+and+dependence:+results+of+the+French+Centre+for+Evaluation+and+Information+on+Pharmacodependence+(CEIP)+Network+survey&amp;author=C+Victorri-Vigneau&amp;author=E+Dailly&amp;author=G+Veyrac&amp;author=P+Jolliet&amp;volume=64&amp;publication_year=2007&amp;pages=198-209&amp;pmid=17324242&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0039"><span class="mixed-citation">Wheatley D. 2005. <span class="ref-title">Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability</span>. <span class="ref-journal">J Psychopharmacol</span>. <span class="ref-vol">19</span>:414–421. [<a href="https://pubmed.ncbi.nlm.nih.gov/15982998">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Psychopharmacol&amp;title=Medicinal+plants+for+insomnia:+a+review+of+their+pharmacology,+efficacy+and+tolerability&amp;author=D+Wheatley&amp;volume=19&amp;publication_year=2005&amp;pages=414-421&amp;pmid=15982998&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0040"><span class="mixed-citation">Wong T, Guin C, Bottiglieri T, Snead OC. 2003. <span class="ref-title">GABA, γ-hydroxybutyric acid, and neurological disease</span>. <span class="ref-journal">Ann Neurol</span>. <span class="ref-vol">54</span>:3–12. [<a href="https://pubmed.ncbi.nlm.nih.gov/12891648">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Ann+Neurol&amp;title=GABA,+%CE%B3-hydroxybutyric+acid,+and+neurological+disease&amp;author=T+Wong&amp;author=C+Guin&amp;author=T+Bottiglieri&amp;author=OC+Snead&amp;volume=54&amp;publication_year=2003&amp;pages=3-12&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0041"><span class="mixed-citation">Yan S, Dufour JP, Meurens M. 2003. <span class="ref-title">Synthesis and characterization of highly pure theanine</span>. <span class="ref-journal">J Tea Sci</span>. <span class="ref-vol">23</span>:99–104. <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Tea+Sci&amp;title=Synthesis+and+characterization+of+highly+pure+theanine&amp;author=S+Yan&amp;author=JP+Dufour&amp;author=M+Meurens&amp;volume=23&amp;publication_year=2003&amp;pages=99-104&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0042"><span class="mixed-citation">Yang H, Lee YC, Han KS, Singh H, Yoon M, Park JH, Cho CW, Cho S. 2013. <span class="ref-title">Green and gold kiwifruit peel ethanol extracts potentiate pentobarbital-induced sleep in mice via a GABAergic mechanism</span>. <span class="ref-journal">Food Chem</span>. <span class="ref-vol">136</span>:160–163. [<a href="https://pubmed.ncbi.nlm.nih.gov/23017407">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Food+Chem&amp;title=Green+and+gold+kiwifruit+peel+ethanol+extracts+potentiate+pentobarbital-induced+sleep+in+mice+via+a+GABAergic+mechanism&amp;author=H+Yang&amp;author=YC+Lee&amp;author=KS+Han&amp;author=H+Singh&amp;author=M+Yoon&amp;volume=136&amp;publication_year=2013&amp;pages=160-163&amp;pmid=23017407&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0043"><span class="mixed-citation">Yang X, Ke C, Zhu J, Wang Y, Zeng W, Huang J. 2018. <span class="ref-title">Enhanced productivity of gamma-amino butyric acid by cascade modifications of a whole-cell biocatalyst</span>. <span class="ref-journal">Appl Microbiol Biotechnol</span>. <span class="ref-vol">102</span>:3623–3633. [<a href="https://pubmed.ncbi.nlm.nih.gov/29516142">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Appl+Microbiol+Biotechnol&amp;title=Enhanced+productivity+of+gamma-amino+butyric+acid+by+cascade+modifications+of+a+whole-cell+biocatalyst&amp;author=X+Yang&amp;author=C+Ke&amp;author=J+Zhu&amp;author=Y+Wang&amp;author=W+Zeng&amp;volume=102&amp;publication_year=2018&amp;pages=3623-3633&amp;pmid=29516142&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0044"><span class="mixed-citation">Yokogoshi H, Mochizuki M, Saitoh K. 1998. <span class="ref-title">Theanine-induced reduction of brain serotonin concentration in rats</span>. <span class="ref-journal">Biosci Biotechnol Biochem</span>. <span class="ref-vol">62</span>:816–817. [<a href="https://pubmed.ncbi.nlm.nih.gov/9614715">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=Biosci+Biotechnol+Biochem&amp;title=Theanine-induced+reduction+of+brain+serotonin+concentration+in+rats&amp;author=H+Yokogoshi&amp;author=M+Mochizuki&amp;author=K+Saitoh&amp;volume=62&amp;publication_year=1998&amp;pages=816-817&amp;pmid=9614715&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li id="CIT0045"><span class="mixed-citation">Zanoli P, Zavatti M. 2008. <span class="ref-title">Pharmacognostic and pharmacological profile of <em>Humulus lupulus</em> L</span>. <span class="ref-journal">J Ethnopharmacol</span>. <span class="ref-vol">116</span>:383–396. [<a href="https://pubmed.ncbi.nlm.nih.gov/18308492">PubMed</a>] <span class="nowrap">[<a role="button" href="https://scholar.google.com/scholar_lookup?journal=J+Ethnopharmacol&amp;title=Pharmacognostic+and+pharmacological+profile+of+Humulus+lupulus+L&amp;author=P+Zanoli&amp;author=M+Zavatti&amp;volume=116&amp;publication_year=2008&amp;pages=383-396&amp;pmid=18308492&amp;" target="_blank" rel="noopener noreferrer" aria-expanded="false" aria-haspopup="true">Google Scholar</a>]</span></span></li>
<li> <a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/35587996/" data-ga-category="cited_by" data-ga-action="35587996" data-ga-label=""><em>Moringa oleifera</em> seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism.</a>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Liu WL, Wu BF, Shang JH, Wang XF, Zhao YL, Huang AX.</span><span class="docsum-journal-citation full-journal-citation">Pharm Biol. 2022 Dec;60(1):810-824. doi: 10.1080/13880209.2022.2056207.</span><span class="citation-part">PMID: <span class="docsum-pmid">35587996</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/35540981/" data-ga-category="cited_by" data-ga-action="35540981" data-ga-label="">4-Hydroxybenzyl alcohol derivatives and their sedative-hypnotic activities.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Zhu HY, Zhang D, Zhang Q, Zhao Y, He ZM, Gao YG, Zhang LX.</span><span class="docsum-journal-citation full-journal-citation">RSC Adv. 2018 May 29;8(35):19539-19550. doi: 10.1039/c8ra01972j. eCollection 2018 May 25.</span><span class="citation-part">PMID: <span class="docsum-pmid">35540981</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/34575986/" data-ga-category="cited_by" data-ga-action="34575986" data-ga-label="">Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Ahn Y, Hong KB, Kim S, Suh HJ, Jo K.</span><span class="docsum-journal-citation full-journal-citation">Int J Mol Sci. 2021 Sep 10;22(18):9822. doi: 10.3390/ijms22189822.</span><span class="citation-part">PMID: <span class="docsum-pmid">34575986</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/30707852/" data-ga-category="cited_by" data-ga-action="30707852" data-ga-label="">GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Kim S, Jo K, Hong KB, Han SH, Suh HJ.</span><span class="docsum-journal-citation full-journal-citation">Pharm Biol. 2019 Dec;57(1):65-73. doi: 10.1080/13880209.2018.1557698.</span><span class="citation-part">PMID: <span class="docsum-pmid">30707852</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/30671124/" data-ga-category="cited_by" data-ga-action="30671124" data-ga-label="">Potential Application of Yokukansan as a Remedy for Parkinson&#8217;s Disease.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Jang JH, Jung K, Kim JS, Jung I, Yoo H, Moon C.</span><span class="docsum-journal-citation full-journal-citation">Evid Based Complement Alternat Med. 2018 Dec 20;2018:1875928. doi: 10.1155/2018/1875928. eCollection 2018.</span><span class="citation-part">PMID: <span class="docsum-pmid">30671124</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> <span class="publication-type spaced-citation-item citation-part">Review.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/36117757/" data-ga-category="cited_by" data-ga-action="36117757" data-ga-label="">Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Manshadi Seyed Ali D, Seyed Alireza M, Mohammad Reza S, Jayran Z, SeyedAhmad S, Shams Ali R, Seyed Saeid M, Ali AA.</span><span class="docsum-journal-citation full-journal-citation">Chin Herb Med. 2020 Nov 26;13(1):136-141. doi: 10.1016/j.chmed.2020.08.002. eCollection 2021 Jan.</span><span class="citation-part">PMID: <span class="docsum-pmid">36117757</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/35896285/" data-ga-category="cited_by" data-ga-action="35896285" data-ga-label="">Herbal supplements in Jordan: a cross-sectional survey of pharmacists&#8217; perspectives and knowledge.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Jalil B, Naser AY, M Prieto J, Heinrich M.</span><span class="docsum-journal-citation full-journal-citation">BMJ Open. 2022 Jul 27;12(7):e057405. doi: 10.1136/bmjopen-2021-057405.</span><span class="citation-part">PMID: <span class="docsum-pmid">35896285</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/35449538/" data-ga-category="cited_by" data-ga-action="35449538" data-ga-label="">A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality <em>via</em> Regulating Brain Electrochemical Activity.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Dasdelen MF, Er S, Kaplan B, Celik S, Beker MC, Orhan C, Tuzcu M, Sahin N, Mamedova H, Sylla S, Komorowski J, Ojalvo SP, Sahin K, Kilic E.</span><span class="docsum-journal-citation full-journal-citation">Front Nutr. 2022 Apr 5;9:874254. doi: 10.3389/fnut.2022.874254. eCollection 2022.</span><span class="citation-part">PMID: <span class="docsum-pmid">35449538</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/35206801/" data-ga-category="cited_by" data-ga-action="35206801" data-ga-label="">Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Szot M, Karpęcka-Gałka E, Dróżdż R, Frączek B.</span><span class="docsum-journal-citation full-journal-citation">Healthcare (Basel). 2022 Jan 18;10(2):186. doi: 10.3390/healthcare10020186.</span><span class="citation-part">PMID: <span class="docsum-pmid">35206801</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> <span class="publication-type spaced-citation-item citation-part">Review.</span></div>
</div>
</li>
<li class="full-docsum">
<div class="docsum-content">
<p><a class="docsum-title" href="https://pubmed.ncbi.nlm.nih.gov/34202628/" data-ga-category="cited_by" data-ga-action="34202628" data-ga-label="">Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes.</a></p>
<div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Way H, Williams G, Hausman-Cohen S, Reeder J.</span><span class="docsum-journal-citation full-journal-citation">J Pers Med. 2021 Jun 24;11(7):596. doi: 10.3390/jpm11070596.</span><span class="citation-part">PMID: <span class="docsum-pmid">34202628</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span></div>
</div>
</li>
</ol>
<p>cited <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/" target="_blank" rel="noopener">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/</a></p>
<p><a href="https://pubmed.ncbi.nlm.nih.gov/27150227/" target="_blank" rel="noopener">https://pubmed.ncbi.nlm.nih.gov/27150227/</a></p>
</div>
</div>
<div class="docsum-citation full-citation"></div>
<div></div>
<div>
<h2 style="text-align: center;"><span style="color: #ff0000;">Learn about how sound can help aid your sleep process:</span></h2>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/why-walnuts-are-a-good-snack-to-eat-before-bed/" target="_blank" rel="noopener">Why Walnuts Are A Good Snack To Eat Before Bed</a></span></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/the-right-noise-pink-white-brown-blue-black-and-red-noise-your-guide-to-a-good-nights-sleep/" target="_blank" rel="noopener"><span style="color: #0000ff;">The Right Noise &#8211; Pink, White ,Brown, Blue, Black, and Red Noise: Your Guide to a Good Night’s Sleep</span></a></h3>
<h3 style="text-align: center;"><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-sleep-better-your-guide-for-good-zzz/" target="_blank" rel="noopener">How to Sleep Better: Your Guide for Good ZZZ</a></span></h3>
<h3 class="sleep-edu-blocks__page-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/everything-you-need-to-know-about-magnesium-and-sleep/" target="_blank" rel="noopener">Everything You Need To Know About Magnesium And Sleep</a></h3>
<h3 class="entry-title" style="text-align: center;"><a href="https://goodshepherdmedia.net/optimizing-the-sleep-wake-cycle/" target="_blank" rel="noopener">Optimizing the Sleep-Wake Cycle</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">How to Reset Your Sleep Cycle When You Live With Insomnia</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/sleep-could-wash-alzheimers-waste-out-of-the-brain/" target="_blank" rel="noopener">The Importance of Sleep with Alzheimer’s</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">What You Eat Affects How You Sleep</a></h3>
<h3 style="text-align: center;"><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">GABA &amp; L-theanine mix Improves </a><a href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/">REM Sleep, Stabilizes mood and helps with depression</a></h3>
<section>
<section>
<div id="ad-centerwell-pos-141-2" class="module ad emb-center-well-ad remove_content_text displayblock" data-google-query-id="CO2HucGbtvwCFbLaGAIdED4IVA">
<section>
<hr />
</section>
</div>
</section>
</section>
<h3 id="what-happens-when-circadian-rhythm-is-off--4" class="wp-block-heading" style="text-align: center;"><span style="color: #ff0000;">What Happens When Circadian Rhythm Is Off?</span><span style="color: #0000ff;"> <a style="color: #0000ff;" href="https://goodshepherdmedia.net/circadian-rhythms-what-are-circadian-rhythms/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">Do You Wake Up Every Night At The Same Time?</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/do-you-wake-up-every-night-at-the-same-time-this-is-what-it-means/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">How to Reset Your Sleep Cycle When You Live With Insomnia</span> <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/how-to-reset-your-sleep-cycle-when-you-live-with-insomnia/" target="_blank" rel="noopener">Learn More</a></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">What You Eat Affects How You Sleep? <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/what-you-eat-affects-how-you-sleep/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<h3 style="text-align: center;"><span style="color: #ff0000;">GABA / L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says <span style="color: #0000ff;"><a style="color: #0000ff;" href="https://goodshepherdmedia.net/gaba-and-l-theanine-mixture-improves-rem-sleep-antidepressant-and-mood-stabilizing-study-says/" target="_blank" rel="noopener">Learn More</a></span></span></h3>
<p>&nbsp;</p>
<hr />
<h2 id="h1"></h2>
</div>
]]></content:encoded>
					
		
		
			</item>
	</channel>
</rss>
