Fri. Jun 7th, 2024

Effects of Black Pepper and L-theanine with Caffeine

 

 

based on the findings it appears there are cognitive-enhancing outcomes of caffeine. Now Caffeine feels good to most of us, starts most of us up…. But some of us have a little trouble sleeping when caffeine is introduced into our diet.  It appears these study’s show caffeine has cognitive-enhancing outcomes. Other Studies included in this article point to Black peppers ability to counteract the bad effects of caffeine.  Also another Study GABA and L-theanine mixture Improves REM Sleep, Antidepressant, and Mood-stabilizing Study Says shows that mixing L-Theanine with Gaba improves mood and sleep.

The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review

Abstract

Attention-deficit hyperactivity disorder (ADHD) affects multiple cognitive domains, including impaired attention, hyperactivity, and increased impulsivity. According to the CDC, 9.4% of children between 2 and 17 years old have been diagnosed with ADHD. Neurotransmitters such as noradrenaline and dopamine have been suggested as crucial players in the pathophysiology of ADHD and are often targets of modern medication. Adenosine receptors types A1 and A2a in the brain are inhibited by caffeine: a stimulant known to augment attention by increasing cholinergic and dopaminergic transmission. The cognitive function of attention is also enhanced by the amino acid: L-theanine. The mechanism of action is that it behaves like a glutamate reuptake inhibitor while also acting in the hippocampus as a competitive low-affinity glutamate receptor antagonist. It’s also shown to have a neuroprotective effect by its action on the gamma aminobutyric acid (GABA)-A receptors. Our systematic review investigates the literature and clinical trials on the cognitive-enhancing effects of caffeine and L-theanine.

Keywords: adhd; caffeine; green tea; l-theanine; l-theanine and caffeine; matcha; memory reconsolidation; mental cognition.


L-theanine partially counteracts caffeine-induced sleep disturbances in rats

Abstract

L-theanine has been reported to inhibit the excitatory effects of caffeine. The present study examined the effects of L-theanine on caffeine-induced sleep disturbances in rats. Rats received the following drug pairings: saline and saline (Control), 7.5 mg/kg caffeine and saline, or 7.5 mg/kg of caffeine followed by various doses of L-theanine (22.5, 37.5, 75, or 150 mg/kg). Vigilance states were divided into: wakefulness (W), transition to slow-wave sleep (tSWS), slow-wave sleep (SWS), and rapid-eye-movement sleep (REMS). Caffeine significantly increased the duration of W and decreased the duration of SWS and REMS compared to the Control. Although L-theanine failed to reverse the caffeine-induced W increase, at 22.5 and 37.5 mg/kg (but not at 75 and 150 mg/kg), it significantly reversed caffeine-induced decreases in SWS. In conclusion, low doses of L-theanine can partially reverse caffeine-induced reductions in SWS; however, effects of L-theanine on caffeine-induced insomnia do not appear to increase dose-dependently.


Effect of Black Pepper ( Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice

Abstract

Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-induced sleep disruption and excitation in mice. Caffeine significantly decreased sleep duration in the pentobarbital-induced sleep test. It also resulted in a significant increase in sleep onset and a decrease in non-rapid eye movement sleep. Moreover, in an open-field test, caffeine-treated mice exhibited a significantly increased time in the center zone and total distance traveled. However, the co-administration of caffeine and PE did not result in similar arousal activities. Thus, our results suggest that PE can be used as a potential therapeutic agent to treat sleep problems and excitatory status associated with caffeine intake.


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  17. Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress.
    Unno K, Noda S, Kawasaki Y, Yamada H, Morita A, Iguchi K, Nakamura Y.J Clin Biochem Nutr. 2017 Nov;61(3):210-216. doi: 10.3164/jcbn.17-6. Epub 2017 Sep 5.PMID: 29203963 Free PMC article.
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https://pubmed.ncbi.nlm.nih.gov/35111479/

https://pubmed.ncbi.nlm.nih.gov/35684048/